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- W1997192719 abstract "Immobilization and the consequent unloading can cause osteopenia both in humans and in animals due to an increased bone resorption and a parallel reduction in bone formation. Non-steroidal anti-inflammatory drugs (NSAIDs), and in particular the aryl propionic acids, are described to prevent bone loss by inhibiting the cyclo-oxygenase activity. In this study we evaluated the role of a classical aryl propionic acid, ketoprofen lysine salt (KLS), in a new model of disuse-induced osteoporosis in the rat. Tail immobilization evoked a time-dependent bone loss in the caudal vertebral bodies, measured densitometrically as a reduction of bone mineral density (BMD) and content (BMC). KLS was administered once daily for 10 days by subcutaneous route at 0.5mg kg−1, a dose lower than that effective to elicit an anti-inflammatory response. In these conditions, KLS completely abolished BMD and BMC decrease observed in the caudal vertebrae after 10-day immobilization, without affecting bone mass in normal (non-immobilized) rats. These results suggest that KLS can exert, besides to its anti-inflammatory effect, an anti-resorptive activity on bone that could be useful in the prevention of disuse-induced osteopenia." @default.
- W1997192719 created "2016-06-24" @default.
- W1997192719 creator A5048735385 @default.
- W1997192719 date "1996-04-01" @default.
- W1997192719 modified "2023-09-25" @default.
- W1997192719 title "KETOPROFEN LYSINE SALT INHIBITS DISUSE-INDUCED OSTEOPENIA IN A NEW NON-TRAUMATIC IMMOBILIZATION MODEL IN THE RAT" @default.
- W1997192719 doi "https://doi.org/10.1006/phrs.1996.0039" @default.
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