FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997202344> ?p ?o ?g. }

• W1997202344 endingPage "1727" @default.
• W1997202344 startingPage "1722" @default.
• W1997202344 abstract "We established a transformed B cell line expressing both IgM and IgG on the cell surface from a patient with hyper IgM immunodeficiency using Epstein-Barr viruses. DNA and RNA of the cells were analyzed. DNA rearrangements of Ig JH gene loci were observed on both chromosomes. Cloning and DNA sequence analyses showed that one has a VHDHJH structure while the other has a DHJH structure. Southern hybridization with 5'-S mu and S gamma region-containing probes indicated germline configuration in the switch regions of mu and gamma genes on both chromosomes. To test expression of mu and gamma chains in the transformed cells at the mRNA-level, we used the polymerase chain reaction with three kinds of synthetic oligonucleotides as primers, one of which was part of the VH gene, while the other two were complementary to parts of C mu and C gamma genes. Sequence analysis of the amplified products showed that the same VHDHJH sequence is directly connected with either the C mu or the C gamma sequence in the mRNAs. This is direct evidence showing that in double isotype-bearing cells one VHDHJH exon in the transcript is alternatively spliced to C mu or C gamma without DNA rearrangement. The defect in this disease could be at the S-S recombination stage." @default.
• W1997202344 created "2016-06-24" @default.
• W1997202344 creator A5006958303 @default.
• W1997202344 creator A5017677055 @default.
• W1997202344 creator A5039889308 @default.
• W1997202344 creator A5070763927 @default.
• W1997202344 creator A5085702312 @default.
• W1997202344 date "1990-06-01" @default.
• W1997202344 modified "2023-10-15" @default.
• W1997202344 title "Presence of immunoglobulin (Ig) M and IgG double isotype-bearing cells and defect of switch recombination in hyper IgM immunodeficiency." @default.
• W1997202344 cites W1482457699 @default.
• W1997202344 cites W1509950949 @default.
• W1997202344 cites W1546739249 @default.
• W1997202344 cites W1828518284 @default.
• W1997202344 cites W1965387339 @default.
• W1997202344 cites W1980889239 @default.
• W1997202344 cites W1985148567 @default.
• W1997202344 cites W1985594948 @default.
• W1997202344 cites W1986059203 @default.
• W1997202344 cites W1989778243 @default.
• W1997202344 cites W2015897818 @default.
• W1997202344 cites W2028622989 @default.
• W1997202344 cites W2032118018 @default.
• W1997202344 cites W2035800046 @default.
• W1997202344 cites W2042651866 @default.
• W1997202344 cites W2043288535 @default.
• W1997202344 cites W2045744309 @default.
• W1997202344 cites W2057658631 @default.
• W1997202344 cites W2057748047 @default.
• W1997202344 cites W2059897736 @default.
• W1997202344 cites W2076899085 @default.
• W1997202344 cites W2081636082 @default.
• W1997202344 cites W2085676209 @default.
• W1997202344 cites W2086955288 @default.
• W1997202344 cites W2095122090 @default.
• W1997202344 cites W2115919802 @default.
• W1997202344 cites W2138270253 @default.
• W1997202344 cites W2145386768 @default.
• W1997202344 cites W2326942225 @default.
• W1997202344 cites W2414532963 @default.
• W1997202344 cites W4237874187 @default.
• W1997202344 cites W87082738 @default.
• W1997202344 doi "https://doi.org/10.1172/jci114627" @default.
• W1997202344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296632" @default.
• W1997202344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2347911" @default.
• W1997202344 hasPublicationYear "1990" @default.
• W1997202344 type Work @default.
• W1997202344 sameAs 1997202344 @default.
• W1997202344 citedByCount "14" @default.
• W1997202344 crossrefType "journal-article" @default.
• W1997202344 hasAuthorship W1997202344A5006958303 @default.
• W1997202344 hasAuthorship W1997202344A5017677055 @default.
• W1997202344 hasAuthorship W1997202344A5039889308 @default.
• W1997202344 hasAuthorship W1997202344A5070763927 @default.
• W1997202344 hasAuthorship W1997202344A5085702312 @default.
• W1997202344 hasBestOaLocation W19972023441 @default.
• W1997202344 hasConcept C104317684 @default.
• W1997202344 hasConcept C129312508 @default.
• W1997202344 hasConcept C137756551 @default.
• W1997202344 hasConcept C153911025 @default.
• W1997202344 hasConcept C159654299 @default.
• W1997202344 hasConcept C2777991845 @default.
• W1997202344 hasConcept C2778453870 @default.
• W1997202344 hasConcept C2992511266 @default.
• W1997202344 hasConcept C542903549 @default.
• W1997202344 hasConcept C54355233 @default.
• W1997202344 hasConcept C552990157 @default.
• W1997202344 hasConcept C86803240 @default.
• W1997202344 hasConcept C96007430 @default.
• W1997202344 hasConceptScore W1997202344C104317684 @default.
• W1997202344 hasConceptScore W1997202344C129312508 @default.
• W1997202344 hasConceptScore W1997202344C137756551 @default.
• W1997202344 hasConceptScore W1997202344C153911025 @default.
• W1997202344 hasConceptScore W1997202344C159654299 @default.
• W1997202344 hasConceptScore W1997202344C2777991845 @default.
• W1997202344 hasConceptScore W1997202344C2778453870 @default.
• W1997202344 hasConceptScore W1997202344C2992511266 @default.
• W1997202344 hasConceptScore W1997202344C542903549 @default.
• W1997202344 hasConceptScore W1997202344C54355233 @default.
• W1997202344 hasConceptScore W1997202344C552990157 @default.
• W1997202344 hasConceptScore W1997202344C86803240 @default.
• W1997202344 hasConceptScore W1997202344C96007430 @default.
• W1997202344 hasIssue "6" @default.
• W1997202344 hasLocation W19972023441 @default.
• W1997202344 hasLocation W19972023442 @default.
• W1997202344 hasLocation W19972023443 @default.
• W1997202344 hasLocation W19972023444 @default.
• W1997202344 hasOpenAccess W1997202344 @default.
• W1997202344 hasPrimaryLocation W19972023441 @default.
• W1997202344 hasRelatedWork W1867533334 @default.
• W1997202344 hasRelatedWork W1993481775 @default.
• W1997202344 hasRelatedWork W2000652406 @default.
• W1997202344 hasRelatedWork W2021824933 @default.
• W1997202344 hasRelatedWork W2153116114 @default.
• W1997202344 hasRelatedWork W2211612344 @default.
• W1997202344 hasRelatedWork W2756428131 @default.
• W1997202344 hasRelatedWork W297888874 @default.
• W1997202344 hasRelatedWork W4313354683 @default.

• next