FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997213238> ?p ?o ?g. }

• W1997213238 endingPage "1068" @default.
• W1997213238 startingPage "1060" @default.
• W1997213238 abstract "About 500,000 new cancer patients will develop brain metastases in 2013. The primary treatment modality for these patients is partial or whole brain irradiation which leads to a progressive, irreversible cognitive impairment. Although the exact mechanisms behind this radiation-induced brain injury are unknown, neuroinflammation in glial populations is hypothesized to play a role. Blockers of the renin-angiotensin system (RAS) prevent radiation-induced cognitive impairment and modulate radiation-induced neuroinflammation. Recent studies suggest that RAS blockers may reduce inflammation by increasing endogenous concentrations of the anti-inflammatory heptapeptide angiotensin-(1-7) [Ang-(1-7)]. Ang-(1-7) binds to the AT(1-7) receptor and inhibits MAP kinase activity to prevent inflammation. This study describes the inflammatory response to radiation in astrocytes characterized by radiation-induced increases in (i) IL-1β and IL-6 gene expression; (ii) COX-2 and GFAP immunoreactivity; (iii) activation of AP-1 and NF-κB transcription factors; and (iv) PKCα, MEK, and ERK (MAP kinase) activation. Treatment with U-0126, a MEK inhibitor, demonstrates that this radiation-induced inflammation in astrocytes is mediated through the MAP kinase pathway. Ang-(1-7) inhibits radiation-induced inflammation, increases in PKCα, and MAP kinase pathway activation (phosphorylation of MEK and ERK). Additionally Ang-(1-7) treatment leads to an increase in dual specificity phosphatase 1 (DUSP1). Furthermore, treatment with sodium vanadate (Na3VO4), a phosphatase inhibitor, blocks Ang-(1-7) inhibition of radiation-induced inflammation and MAP kinase activation, suggesting that Ang-(1-7) alters phosphatase activity to inhibit radiation-induced inflammation. These data suggest that RAS blockers inhibit radiation-induced inflammation and prevent radiation-induced cognitive impairment not only by reducing Ang II but also by increasing Ang-(1-7) levels." @default.
• W1997213238 created "2016-06-24" @default.
• W1997213238 creator A5049630935 @default.
• W1997213238 creator A5053671289 @default.
• W1997213238 creator A5057203129 @default.
• W1997213238 creator A5075221615 @default.
• W1997213238 creator A5076321003 @default.
• W1997213238 date "2013-12-01" @default.
• W1997213238 modified "2023-10-04" @default.
• W1997213238 title "Angiotensin-(1–7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling" @default.
• W1997213238 cites W1506057870 @default.
• W1997213238 cites W1534452194 @default.
• W1997213238 cites W1563130436 @default.
• W1997213238 cites W1586043264 @default.
• W1997213238 cites W1968862500 @default.
• W1997213238 cites W1969133124 @default.
• W1997213238 cites W1974105812 @default.
• W1997213238 cites W1977838764 @default.
• W1997213238 cites W1979387004 @default.
• W1997213238 cites W1986827436 @default.
• W1997213238 cites W1988831950 @default.
• W1997213238 cites W1995966536 @default.
• W1997213238 cites W1996887338 @default.
• W1997213238 cites W2002717717 @default.
• W1997213238 cites W2003614844 @default.
• W1997213238 cites W2010568688 @default.
• W1997213238 cites W2028944007 @default.
• W1997213238 cites W2031809301 @default.
• W1997213238 cites W2039945983 @default.
• W1997213238 cites W2041237265 @default.
• W1997213238 cites W2049923017 @default.
• W1997213238 cites W2052149833 @default.
• W1997213238 cites W2055385665 @default.
• W1997213238 cites W2055736315 @default.
• W1997213238 cites W2062410438 @default.
• W1997213238 cites W2065546836 @default.
• W1997213238 cites W2074837982 @default.
• W1997213238 cites W2075678264 @default.
• W1997213238 cites W2078051927 @default.
• W1997213238 cites W2078924802 @default.
• W1997213238 cites W2085116908 @default.
• W1997213238 cites W2095806333 @default.
• W1997213238 cites W2099713879 @default.
• W1997213238 cites W2104220103 @default.
• W1997213238 cites W2106787323 @default.
• W1997213238 cites W2107950465 @default.
• W1997213238 cites W2108783129 @default.
• W1997213238 cites W2110427753 @default.
• W1997213238 cites W2113419020 @default.
• W1997213238 cites W2117144091 @default.
• W1997213238 cites W2137771267 @default.
• W1997213238 cites W2138043907 @default.
• W1997213238 cites W2140980734 @default.
• W1997213238 cites W2141351251 @default.
• W1997213238 cites W2146413113 @default.
• W1997213238 cites W2151190145 @default.
• W1997213238 cites W2151400960 @default.
• W1997213238 cites W2162020808 @default.
• W1997213238 cites W2162318275 @default.
• W1997213238 cites W2165948908 @default.
• W1997213238 cites W2170715646 @default.
• W1997213238 cites W3217532623 @default.
• W1997213238 doi "https://doi.org/10.1016/j.freeradbiomed.2013.08.183" @default.
• W1997213238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3879043" @default.
• W1997213238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24012919" @default.
• W1997213238 hasPublicationYear "2013" @default.
• W1997213238 type Work @default.
• W1997213238 sameAs 1997213238 @default.
• W1997213238 citedByCount "48" @default.
• W1997213238 countsByYear W19972132382014 @default.
• W1997213238 countsByYear W19972132382015 @default.
• W1997213238 countsByYear W19972132382016 @default.
• W1997213238 countsByYear W19972132382017 @default.
• W1997213238 countsByYear W19972132382018 @default.
• W1997213238 countsByYear W19972132382019 @default.
• W1997213238 countsByYear W19972132382020 @default.
• W1997213238 countsByYear W19972132382021 @default.
• W1997213238 countsByYear W19972132382022 @default.
• W1997213238 countsByYear W19972132382023 @default.
• W1997213238 crossrefType "journal-article" @default.
• W1997213238 hasAuthorship W1997213238A5049630935 @default.
• W1997213238 hasAuthorship W1997213238A5053671289 @default.
• W1997213238 hasAuthorship W1997213238A5057203129 @default.
• W1997213238 hasAuthorship W1997213238A5075221615 @default.
• W1997213238 hasAuthorship W1997213238A5076321003 @default.
• W1997213238 hasBestOaLocation W19972132382 @default.
• W1997213238 hasConcept C11960822 @default.
• W1997213238 hasConcept C126322002 @default.
• W1997213238 hasConcept C134018914 @default.
• W1997213238 hasConcept C170493617 @default.
• W1997213238 hasConcept C178666793 @default.
• W1997213238 hasConcept C184235292 @default.
• W1997213238 hasConcept C185592680 @default.
• W1997213238 hasConcept C2776914184 @default.
• W1997213238 hasConcept C2908929049 @default.
• W1997213238 hasConcept C502942594 @default.
• W1997213238 hasConcept C57074206 @default.
• W1997213238 hasConcept C62478195 @default.

• next