FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997218706> ?p ?o ?g. }

• W1997218706 endingPage "3709" @default.
• W1997218706 startingPage "3701" @default.
• W1997218706 abstract "Presently, there are no FDA-approved medications to treat cocaine addiction. Active vaccination has emerged as one approach to intervene through the rapid sequestering of the circulating drug, thus terminating both psychoactive effects and drug toxicity. Herein, we report our efforts examining two complementary, but mechanistically distinct active vaccines, i.e., noncatalytic and catalytic, for cocaine treatment. A cocaine-like hapten GNE and a cocaine transition-state analogue GNT were used to generate the active vaccines, respectively. GNE-KLH (keyhole limpet hemocyannin) was found to elicit persistent high-titer, cocaine-specific antibodies and blunt cocaine-induced locomotor behaviors. Catalytic antibodies induced by GNT-KLH were also shown to produce potent titers and suppress locomotor response in mice; however, upon repeated cocaine challenges, the vaccine's protecting effects waned. In depth kinetic analysis suggested that loss of catalytic activity was due to antibody modification by cocaine. The work provides new insights for the development of active vaccines for the treatment of cocaine abuse." @default.
• W1997218706 created "2016-06-24" @default.
• W1997218706 creator A5022020530 @default.
• W1997218706 creator A5024312004 @default.
• W1997218706 creator A5032779695 @default.
• W1997218706 creator A5040621910 @default.
• W1997218706 creator A5075246876 @default.
• W1997218706 creator A5080567875 @default.
• W1997218706 date "2013-04-29" @default.
• W1997218706 modified "2023-09-26" @default.
• W1997218706 title "Probing Active Cocaine Vaccination Performance through Catalytic and Noncatalytic Hapten Design" @default.
• W1997218706 cites W1423223045 @default.
• W1997218706 cites W1607280480 @default.
• W1997218706 cites W1964569212 @default.
• W1997218706 cites W1971966814 @default.
• W1997218706 cites W1974053573 @default.
• W1997218706 cites W1975485717 @default.
• W1997218706 cites W1984120373 @default.
• W1997218706 cites W1993161822 @default.
• W1997218706 cites W1996166960 @default.
• W1997218706 cites W2000826257 @default.
• W1997218706 cites W2011308243 @default.
• W1997218706 cites W2020381314 @default.
• W1997218706 cites W2029629927 @default.
• W1997218706 cites W2038105413 @default.
• W1997218706 cites W2044368734 @default.
• W1997218706 cites W2044527158 @default.
• W1997218706 cites W2059334369 @default.
• W1997218706 cites W2062734945 @default.
• W1997218706 cites W2062831265 @default.
• W1997218706 cites W2064083629 @default.
• W1997218706 cites W2075478212 @default.
• W1997218706 cites W2083918338 @default.
• W1997218706 cites W2099020441 @default.
• W1997218706 cites W2108249677 @default.
• W1997218706 cites W2123951107 @default.
• W1997218706 cites W2127021519 @default.
• W1997218706 cites W2137037755 @default.
• W1997218706 cites W2158223715 @default.
• W1997218706 cites W2165697122 @default.
• W1997218706 cites W2949256368 @default.
• W1997218706 cites W2952920474 @default.
• W1997218706 doi "https://doi.org/10.1021/jm400228w" @default.
• W1997218706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3691275" @default.
• W1997218706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23627877" @default.
• W1997218706 hasPublicationYear "2013" @default.
• W1997218706 type Work @default.
• W1997218706 sameAs 1997218706 @default.
• W1997218706 citedByCount "32" @default.
• W1997218706 countsByYear W19972187062014 @default.
• W1997218706 countsByYear W19972187062015 @default.
• W1997218706 countsByYear W19972187062016 @default.
• W1997218706 countsByYear W19972187062017 @default.
• W1997218706 countsByYear W19972187062018 @default.
• W1997218706 countsByYear W19972187062019 @default.
• W1997218706 countsByYear W19972187062020 @default.
• W1997218706 countsByYear W19972187062021 @default.
• W1997218706 countsByYear W19972187062022 @default.
• W1997218706 countsByYear W19972187062023 @default.
• W1997218706 crossrefType "journal-article" @default.
• W1997218706 hasAuthorship W1997218706A5022020530 @default.
• W1997218706 hasAuthorship W1997218706A5024312004 @default.
• W1997218706 hasAuthorship W1997218706A5032779695 @default.
• W1997218706 hasAuthorship W1997218706A5040621910 @default.
• W1997218706 hasAuthorship W1997218706A5075246876 @default.
• W1997218706 hasAuthorship W1997218706A5080567875 @default.
• W1997218706 hasBestOaLocation W19972187062 @default.
• W1997218706 hasConcept C118552586 @default.
• W1997218706 hasConcept C159654299 @default.
• W1997218706 hasConcept C185592680 @default.
• W1997218706 hasConcept C203014093 @default.
• W1997218706 hasConcept C21951064 @default.
• W1997218706 hasConcept C2778943623 @default.
• W1997218706 hasConcept C2780035454 @default.
• W1997218706 hasConcept C2780801004 @default.
• W1997218706 hasConcept C29144244 @default.
• W1997218706 hasConcept C2991691389 @default.
• W1997218706 hasConcept C32611913 @default.
• W1997218706 hasConcept C48856860 @default.
• W1997218706 hasConcept C71924100 @default.
• W1997218706 hasConcept C98274493 @default.
• W1997218706 hasConceptScore W1997218706C118552586 @default.
• W1997218706 hasConceptScore W1997218706C159654299 @default.
• W1997218706 hasConceptScore W1997218706C185592680 @default.
• W1997218706 hasConceptScore W1997218706C203014093 @default.
• W1997218706 hasConceptScore W1997218706C21951064 @default.
• W1997218706 hasConceptScore W1997218706C2778943623 @default.
• W1997218706 hasConceptScore W1997218706C2780035454 @default.
• W1997218706 hasConceptScore W1997218706C2780801004 @default.
• W1997218706 hasConceptScore W1997218706C29144244 @default.
• W1997218706 hasConceptScore W1997218706C2991691389 @default.
• W1997218706 hasConceptScore W1997218706C32611913 @default.
• W1997218706 hasConceptScore W1997218706C48856860 @default.
• W1997218706 hasConceptScore W1997218706C71924100 @default.
• W1997218706 hasConceptScore W1997218706C98274493 @default.
• W1997218706 hasIssue "9" @default.
• W1997218706 hasLocation W19972187061 @default.
• W1997218706 hasLocation W19972187062 @default.

• next