FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997233598> ?p ?o ?g. }

• W1997233598 endingPage "470" @default.
• W1997233598 startingPage "460" @default.
• W1997233598 abstract "•Epigenetic modifications are long-lived layers of past transcriptional events. •The relationship of DNA methylation to transcription depends on genomic context. •Noncoding RNAs act as epigenetic layers and players that influence chromatin states. •Chromatin loops and long-range interactions are observed in neurodevelopment. Epigenetic mechanisms convey information above and beyond the sequence of DNA, so it is predicted that they are critical in the complex regulation of brain development and explain the long-lived effects of environmental cues on pre- and early post-natal brain development. Neurons have a complex epigenetic landscape that changes dynamically with transcriptional activity in early life. Here, we summarize progress in our understanding of the discrete layers of the dynamic methylome, chromatin proteome, noncoding RNAs, chromatin loops, and long-range interactions in neuronal development and maturation. Many neurodevelopmental disorders have genetic alterations in these epigenetic modifications or regulators, and these human genetics lessons have demonstrated the importance of these epigenetic players and the epigenetic layers that transcriptional events lay down in the early brain. Epigenetic mechanisms convey information above and beyond the sequence of DNA, so it is predicted that they are critical in the complex regulation of brain development and explain the long-lived effects of environmental cues on pre- and early post-natal brain development. Neurons have a complex epigenetic landscape that changes dynamically with transcriptional activity in early life. Here, we summarize progress in our understanding of the discrete layers of the dynamic methylome, chromatin proteome, noncoding RNAs, chromatin loops, and long-range interactions in neuronal development and maturation. Many neurodevelopmental disorders have genetic alterations in these epigenetic modifications or regulators, and these human genetics lessons have demonstrated the importance of these epigenetic players and the epigenetic layers that transcriptional events lay down in the early brain." @default.
• W1997233598 created "2016-06-24" @default.
• W1997233598 creator A5010417321 @default.
• W1997233598 creator A5013823260 @default.
• W1997233598 creator A5049141611 @default.
• W1997233598 date "2013-08-01" @default.
• W1997233598 modified "2023-10-07" @default.
• W1997233598 title "Epigenetic layers and players underlying neurodevelopment" @default.
• W1997233598 cites W1559742681 @default.
• W1997233598 cites W1964159332 @default.
• W1997233598 cites W1967706132 @default.
• W1997233598 cites W1968717432 @default.
• W1997233598 cites W1970069445 @default.
• W1997233598 cites W1970741980 @default.
• W1997233598 cites W1973754014 @default.
• W1997233598 cites W1976787939 @default.
• W1997233598 cites W1977308882 @default.
• W1997233598 cites W1978170093 @default.
• W1997233598 cites W1979526394 @default.
• W1997233598 cites W1979768717 @default.
• W1997233598 cites W1979892065 @default.
• W1997233598 cites W1981463058 @default.
• W1997233598 cites W1984124345 @default.
• W1997233598 cites W1984783889 @default.
• W1997233598 cites W1986911664 @default.
• W1997233598 cites W1995885578 @default.
• W1997233598 cites W1997025224 @default.
• W1997233598 cites W1999155341 @default.
• W1997233598 cites W1999746344 @default.
• W1997233598 cites W2001369690 @default.
• W1997233598 cites W2001936578 @default.
• W1997233598 cites W2002676132 @default.
• W1997233598 cites W2006107100 @default.
• W1997233598 cites W2010043305 @default.
• W1997233598 cites W2014787267 @default.
• W1997233598 cites W2017107955 @default.
• W1997233598 cites W2018947009 @default.
• W1997233598 cites W2019904951 @default.
• W1997233598 cites W2024190224 @default.
• W1997233598 cites W2025611970 @default.
• W1997233598 cites W2030222772 @default.
• W1997233598 cites W2031123443 @default.
• W1997233598 cites W2031896201 @default.
• W1997233598 cites W2032882684 @default.
• W1997233598 cites W2035310577 @default.
• W1997233598 cites W2035659472 @default.
• W1997233598 cites W2040600097 @default.
• W1997233598 cites W2040675004 @default.
• W1997233598 cites W2040900461 @default.
• W1997233598 cites W2042930277 @default.
• W1997233598 cites W2044763721 @default.
• W1997233598 cites W2046387002 @default.
• W1997233598 cites W2047332133 @default.
• W1997233598 cites W2052130151 @default.
• W1997233598 cites W2053293102 @default.
• W1997233598 cites W2053758959 @default.
• W1997233598 cites W2058835062 @default.
• W1997233598 cites W2059099579 @default.
• W1997233598 cites W2059968749 @default.
• W1997233598 cites W2062247105 @default.
• W1997233598 cites W2062872787 @default.
• W1997233598 cites W2063011506 @default.
• W1997233598 cites W2064756496 @default.
• W1997233598 cites W2064943181 @default.
• W1997233598 cites W2064977733 @default.
• W1997233598 cites W2067004457 @default.
• W1997233598 cites W2067523496 @default.
• W1997233598 cites W2069169829 @default.
• W1997233598 cites W2070021921 @default.
• W1997233598 cites W2071154937 @default.
• W1997233598 cites W2071271349 @default.
• W1997233598 cites W2072924157 @default.
• W1997233598 cites W2074452993 @default.
• W1997233598 cites W2076312647 @default.
• W1997233598 cites W2077065713 @default.
• W1997233598 cites W2080571195 @default.
• W1997233598 cites W2087616533 @default.
• W1997233598 cites W2090037139 @default.
• W1997233598 cites W2092992881 @default.
• W1997233598 cites W2096556455 @default.
• W1997233598 cites W2097081350 @default.
• W1997233598 cites W2101259235 @default.
• W1997233598 cites W2104143100 @default.
• W1997233598 cites W2107552666 @default.
• W1997233598 cites W2108664872 @default.
• W1997233598 cites W2110621553 @default.
• W1997233598 cites W2111584908 @default.
• W1997233598 cites W2111688179 @default.
• W1997233598 cites W2112001233 @default.
• W1997233598 cites W2112655992 @default.
• W1997233598 cites W2113486281 @default.
• W1997233598 cites W2113995752 @default.
• W1997233598 cites W2115818350 @default.
• W1997233598 cites W2116236561 @default.
• W1997233598 cites W2116881442 @default.
• W1997233598 cites W2117792884 @default.
• W1997233598 cites W2118933386 @default.
• W1997233598 cites W2121423419 @default.

• next