Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997233742> ?p ?o ?g. }
- W1997233742 endingPage "20" @default.
- W1997233742 startingPage "4" @default.
- W1997233742 abstract "The declining efficiency of myelin regeneration in individuals with multiple sclerosis has stimulated a search for ways by which it might be therapeutically enhanced. Here we have used gene expression profiling on purified murine oligodendrocyte progenitor cells (OPCs), the remyelinating cells of the adult CNS, to obtain a comprehensive picture of how they become activated after demyelination and how this enables them to contribute to remyelination. We find that adult OPCs have a transcriptome more similar to that of oligodendrocytes than to neonatal OPCs, but revert to a neonatal-like transcriptome when activated. Part of the activation response involves increased expression of two genes of the innate immune system, IL1β and CCL2, which enhance the mobilization of OPCs. Our results add a new dimension to the role of the innate immune system in CNS regeneration, revealing how OPCs themselves contribute to the postinjury inflammatory milieu by producing cytokines that directly enhance their repopulation of areas of demyelination and hence their ability to contribute to remyelination." @default.
- W1997233742 created "2016-06-24" @default.
- W1997233742 creator A5004511038 @default.
- W1997233742 creator A5013660009 @default.
- W1997233742 creator A5016453884 @default.
- W1997233742 creator A5017275450 @default.
- W1997233742 creator A5023237841 @default.
- W1997233742 creator A5044487737 @default.
- W1997233742 creator A5053222670 @default.
- W1997233742 creator A5054561765 @default.
- W1997233742 creator A5057971663 @default.
- W1997233742 creator A5067992372 @default.
- W1997233742 creator A5081730157 @default.
- W1997233742 date "2015-01-07" @default.
- W1997233742 modified "2023-10-17" @default.
- W1997233742 title "Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration" @default.
- W1997233742 cites W1790197493 @default.
- W1997233742 cites W1937179228 @default.
- W1997233742 cites W1965857486 @default.
- W1997233742 cites W1969694035 @default.
- W1997233742 cites W1984891852 @default.
- W1997233742 cites W1989398840 @default.
- W1997233742 cites W1996611512 @default.
- W1997233742 cites W2002353472 @default.
- W1997233742 cites W2021328937 @default.
- W1997233742 cites W2022029245 @default.
- W1997233742 cites W2033322963 @default.
- W1997233742 cites W2035820932 @default.
- W1997233742 cites W2036675289 @default.
- W1997233742 cites W2038757125 @default.
- W1997233742 cites W2047975101 @default.
- W1997233742 cites W2050989030 @default.
- W1997233742 cites W2052580925 @default.
- W1997233742 cites W2062403533 @default.
- W1997233742 cites W2063934228 @default.
- W1997233742 cites W2069748884 @default.
- W1997233742 cites W2072990016 @default.
- W1997233742 cites W2075041269 @default.
- W1997233742 cites W2085217436 @default.
- W1997233742 cites W2086237072 @default.
- W1997233742 cites W2086289885 @default.
- W1997233742 cites W2088378788 @default.
- W1997233742 cites W2091102323 @default.
- W1997233742 cites W2100119722 @default.
- W1997233742 cites W2113672425 @default.
- W1997233742 cites W2121141076 @default.
- W1997233742 cites W2122587876 @default.
- W1997233742 cites W2124940469 @default.
- W1997233742 cites W2144762351 @default.
- W1997233742 cites W2145016172 @default.
- W1997233742 cites W2146876394 @default.
- W1997233742 cites W2149924247 @default.
- W1997233742 cites W2152131288 @default.
- W1997233742 cites W2160413407 @default.
- W1997233742 cites W2161123040 @default.
- W1997233742 cites W2161784528 @default.
- W1997233742 cites W2166323322 @default.
- W1997233742 cites W2168107848 @default.
- W1997233742 cites W2171108041 @default.
- W1997233742 cites W2994590400 @default.
- W1997233742 cites W4253002305 @default.
- W1997233742 doi "https://doi.org/10.1523/jneurosci.0849-14.2015" @default.
- W1997233742 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6605244" @default.
- W1997233742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25568099" @default.
- W1997233742 hasPublicationYear "2015" @default.
- W1997233742 type Work @default.
- W1997233742 sameAs 1997233742 @default.
- W1997233742 citedByCount "205" @default.
- W1997233742 countsByYear W19972337422015 @default.
- W1997233742 countsByYear W19972337422016 @default.
- W1997233742 countsByYear W19972337422017 @default.
- W1997233742 countsByYear W19972337422018 @default.
- W1997233742 countsByYear W19972337422019 @default.
- W1997233742 countsByYear W19972337422020 @default.
- W1997233742 countsByYear W19972337422021 @default.
- W1997233742 countsByYear W19972337422022 @default.
- W1997233742 countsByYear W19972337422023 @default.
- W1997233742 crossrefType "journal-article" @default.
- W1997233742 hasAuthorship W1997233742A5004511038 @default.
- W1997233742 hasAuthorship W1997233742A5013660009 @default.
- W1997233742 hasAuthorship W1997233742A5016453884 @default.
- W1997233742 hasAuthorship W1997233742A5017275450 @default.
- W1997233742 hasAuthorship W1997233742A5023237841 @default.
- W1997233742 hasAuthorship W1997233742A5044487737 @default.
- W1997233742 hasAuthorship W1997233742A5053222670 @default.
- W1997233742 hasAuthorship W1997233742A5054561765 @default.
- W1997233742 hasAuthorship W1997233742A5057971663 @default.
- W1997233742 hasAuthorship W1997233742A5067992372 @default.
- W1997233742 hasAuthorship W1997233742A5081730157 @default.
- W1997233742 hasBestOaLocation W19972337421 @default.
- W1997233742 hasConcept C104317684 @default.
- W1997233742 hasConcept C136449434 @default.
- W1997233742 hasConcept C150194340 @default.
- W1997233742 hasConcept C162317418 @default.
- W1997233742 hasConcept C169760540 @default.
- W1997233742 hasConcept C171056886 @default.
- W1997233742 hasConcept C201750760 @default.
- W1997233742 hasConcept C203014093 @default.