Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997245512> ?p ?o ?g. }
- W1997245512 endingPage "843" @default.
- W1997245512 startingPage "830" @default.
- W1997245512 abstract "Treatment of major depression with antidepressants is generally associated with a delay in onset of clinical response. Functional brain correlates of this phenomenon have not been previously characterized.Time course of changes in brain glucose metabolism were measured using positron emission tomography in hospitalized unipolar depressed patients treated with fluoxetine. Time-specific and response-specific effects were examined at 1 and 6 weeks of treatment.Changes were seen over time, and characterized by three distinct patterns: 1) common changes at 1 and 6 weeks, 2) reversal of the 1-week pattern at 6 weeks, and 3) unique changes seen only after chronic treatment. Fluoxetine responders and nonresponders, similar at 1 week, were differentiated by their 6-week pattern. Clinical improvement was uniquely associated with limbic and striatal decreases (subgenual cingulate, hippocampus, insula, and pallidum) and brain stem and dorsal cortical increases (prefrontal, parietal, anterior, and posterior cingulate). Failed response was associated with a persistent 1-week pattern and absence of either subgenual cingulate or prefrontal changes.Chronic treatment and clinical response to fluoxetine was associated with a reciprocal pattern of subcortical and limbic decreases and cortical increases. Reversal in the week-1 pattern at 6 weeks suggests a process of adaptation in specific brain regions over time in response to sustained serotonin reuptake inhibition. The inverse patterns in responders and nonresponders also suggests that failure to induce these adaptive changes may underlie treatment nonresponse." @default.
- W1997245512 created "2016-06-24" @default.
- W1997245512 creator A5026199142 @default.
- W1997245512 creator A5030452734 @default.
- W1997245512 creator A5044127183 @default.
- W1997245512 creator A5052275856 @default.
- W1997245512 creator A5054362948 @default.
- W1997245512 creator A5054668430 @default.
- W1997245512 creator A5057181892 @default.
- W1997245512 date "2000-10-01" @default.
- W1997245512 modified "2023-10-18" @default.
- W1997245512 title "Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response" @default.
- W1997245512 cites W153159512 @default.
- W1997245512 cites W158383285 @default.
- W1997245512 cites W1594303435 @default.
- W1997245512 cites W1601342503 @default.
- W1997245512 cites W1665095741 @default.
- W1997245512 cites W1666187844 @default.
- W1997245512 cites W1909424429 @default.
- W1997245512 cites W1928975456 @default.
- W1997245512 cites W1939360364 @default.
- W1997245512 cites W1944132902 @default.
- W1997245512 cites W1950744654 @default.
- W1997245512 cites W1955250457 @default.
- W1997245512 cites W1964795016 @default.
- W1997245512 cites W1969717350 @default.
- W1997245512 cites W1972777532 @default.
- W1997245512 cites W1973125755 @default.
- W1997245512 cites W1976892326 @default.
- W1997245512 cites W1976966905 @default.
- W1997245512 cites W1982588519 @default.
- W1997245512 cites W1983160636 @default.
- W1997245512 cites W1986507555 @default.
- W1997245512 cites W1989399430 @default.
- W1997245512 cites W1990145288 @default.
- W1997245512 cites W1991434325 @default.
- W1997245512 cites W1996844671 @default.
- W1997245512 cites W1999858294 @default.
- W1997245512 cites W1999961963 @default.
- W1997245512 cites W2001249543 @default.
- W1997245512 cites W2008288415 @default.
- W1997245512 cites W2019316537 @default.
- W1997245512 cites W2020135601 @default.
- W1997245512 cites W2020754901 @default.
- W1997245512 cites W2020995685 @default.
- W1997245512 cites W2022064668 @default.
- W1997245512 cites W2022874681 @default.
- W1997245512 cites W2023801511 @default.
- W1997245512 cites W2024256650 @default.
- W1997245512 cites W2024286694 @default.
- W1997245512 cites W2025304359 @default.
- W1997245512 cites W2027702949 @default.
- W1997245512 cites W2028524283 @default.
- W1997245512 cites W2034770460 @default.
- W1997245512 cites W2035266273 @default.
- W1997245512 cites W2039391993 @default.
- W1997245512 cites W2040263710 @default.
- W1997245512 cites W2044710410 @default.
- W1997245512 cites W2049279228 @default.
- W1997245512 cites W2050579590 @default.
- W1997245512 cites W2051691068 @default.
- W1997245512 cites W2057909182 @default.
- W1997245512 cites W2058132039 @default.
- W1997245512 cites W2062650195 @default.
- W1997245512 cites W2063764296 @default.
- W1997245512 cites W2064399227 @default.
- W1997245512 cites W2064611362 @default.
- W1997245512 cites W2070477558 @default.
- W1997245512 cites W2071127142 @default.
- W1997245512 cites W2072860869 @default.
- W1997245512 cites W2073266669 @default.
- W1997245512 cites W2075327466 @default.
- W1997245512 cites W2075623469 @default.
- W1997245512 cites W2082646619 @default.
- W1997245512 cites W2083468083 @default.
- W1997245512 cites W2084388248 @default.
- W1997245512 cites W2084836447 @default.
- W1997245512 cites W2087944069 @default.
- W1997245512 cites W2090203522 @default.
- W1997245512 cites W2094106822 @default.
- W1997245512 cites W2105300968 @default.
- W1997245512 cites W2105809102 @default.
- W1997245512 cites W2106918877 @default.
- W1997245512 cites W2107995274 @default.
- W1997245512 cites W2114613490 @default.
- W1997245512 cites W2115022263 @default.
- W1997245512 cites W2121185215 @default.
- W1997245512 cites W2143087778 @default.
- W1997245512 cites W2144538553 @default.
- W1997245512 cites W2146162140 @default.
- W1997245512 cites W2146233605 @default.
- W1997245512 cites W2146747402 @default.
- W1997245512 cites W2150215731 @default.
- W1997245512 cites W2152351656 @default.
- W1997245512 cites W2160048601 @default.
- W1997245512 cites W2162121368 @default.
- W1997245512 cites W2169615651 @default.
- W1997245512 cites W2170915041 @default.