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• W1997250837 abstract "With the advent of cyclosporin A, accelerated coronary arteriosclerosis has become the major impediment to the long-term survival of heart transplant recipients. Due to epidemiologic reports suggesting a salutary effect of fish oil, the dose response of fish oil on graft coronary arteriosclerosis in a rabbit heterotopic cardiac allograft model was assessed using safflower oil as a caloric control. Seven groups of New Zealand White rabbits (n = 10/group) received heterotopic heart transplants from Dutch-Belted donors and were immunosuppressed with low-dose cyclosporin A (7.5 mg/kg/day). Group 1 animals were fed a normal diet and served as control. Group 2,3, and 4 animals received a daily supplement of low- (0.25 mL/kg/day), medium- (0.75 mL/ kg/day), and high- (1.5 mL/kg/day) dose fish oil (116 mg n-3 polyunsaturated fatty acid/mL), respectively. Group 5,6, and 7 animals were supplemented with equivalent doses of safflower oil (i.e., 0.25, 0.75, and 1.5 mL/kg/day). Oil-supplemented rabbits were pretreated for 3 weeks before transplantation and maintained on the same diet for 6 weeks after operation. The extent of graft coronary arteriosclerosis was quantified using computer-assisted, morphometric planimetry. When the animals were killed, cyclosporin A was associated with elevated plasma total cholesterol and triglyceride levels in the control group. While safflower oil prevented the increase in plasma lipids at all dosages, fish oil ameliorated the cyclosporin-induced increase in total cholesterol only with high doses. Compared to control animals, there was a trend for more graft vessel disease with increasing fish oil dose, as assessed by mean luminal occlusion and intimal thickness. A steeper trend was observed for increasing doses of safflower oil; compared to the high-dose safflower oil group, animals supplemented with low-dose safflower oil had less mean luminal occlusion (16.3% ± 5.9% versus 41.4% ± 7.6%, p ≤ 0.017) and intimal thickness (7.9 ± 1.9 μm versus 34.0 ± 13.0 μm, analysis of variance: p = 0.054). Low-dose safflower" @default.
• W1997250837 created "2016-06-24" @default.
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• W1997250837 date "1991-08-01" @default.
• W1997250837 modified "2023-10-11" @default.
• W1997250837 title "Dose Response of Fish Oil Versus Safflower Oil on Graft Arteriosclerosis in Rabbit Heterotopic Cardiac Allografts" @default.
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• W1997250837 doi "https://doi.org/10.1097/00000658-199108000-00010" @default.
• W1997250837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1358515" @default.
• W1997250837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1867523" @default.
• W1997250837 hasPublicationYear "1991" @default.
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