Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997251454> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1997251454 endingPage "70" @default.
- W1997251454 startingPage "64" @default.
- W1997251454 abstract "Astrocytes maintained in a chemically defined media undergo differentiation and a parallel increase in pyruvate kinase specific activity. These changes are accompanied by a shift in the isoelectrofocusing pattern, but not by expression of pyruvate kinase M4 the characteristic adult rat brain isozyme. Thus, this chemically defined media lacks a substance required to induce pyruvate kinase M synthesis and this function can be uncoupled from other aspects of cellular differentiation. The uncoupling of pyruvate kinase maturation from cellular differentiation and the observation of only a single, 2.3 kilobase, pyruvate kinase mRNA molecule at different stages of the postnatal development of rat brain support the concept that the K- to M-isoform transformation is a posttranscriptional event. The effect of the individual components of this chemically defined medium on pyruvate kinase specific activity was studied by eliminating one component at a time. The increase in activity was found to be completely dependent upon fibroblastic growth factor and prostaglandin F2α and was partially dependent on the simultaneous presence of insulin." @default.
- W1997251454 created "2016-06-24" @default.
- W1997251454 creator A5036328741 @default.
- W1997251454 creator A5067289994 @default.
- W1997251454 date "1989-05-01" @default.
- W1997251454 modified "2023-09-23" @default.
- W1997251454 title "Expression of pyruvate kinase in astrocytes induced to differentiate in vitro" @default.
- W1997251454 cites W1964187757 @default.
- W1997251454 cites W1965750059 @default.
- W1997251454 cites W1971238778 @default.
- W1997251454 cites W1973717011 @default.
- W1997251454 cites W1977696904 @default.
- W1997251454 cites W1983315235 @default.
- W1997251454 cites W1993688458 @default.
- W1997251454 cites W1997322256 @default.
- W1997251454 cites W1997848870 @default.
- W1997251454 cites W2001696140 @default.
- W1997251454 cites W2004906161 @default.
- W1997251454 cites W2011059998 @default.
- W1997251454 cites W2019956654 @default.
- W1997251454 cites W2059994807 @default.
- W1997251454 cites W2062825381 @default.
- W1997251454 cites W2074231158 @default.
- W1997251454 cites W2077077811 @default.
- W1997251454 cites W2079267777 @default.
- W1997251454 cites W2086955288 @default.
- W1997251454 cites W2110011113 @default.
- W1997251454 cites W2328637548 @default.
- W1997251454 cites W2912401662 @default.
- W1997251454 cites W4293247451 @default.
- W1997251454 doi "https://doi.org/10.1002/jnr.490230109" @default.
- W1997251454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2746698" @default.
- W1997251454 hasPublicationYear "1989" @default.
- W1997251454 type Work @default.
- W1997251454 sameAs 1997251454 @default.
- W1997251454 citedByCount "3" @default.
- W1997251454 countsByYear W19972514542019 @default.
- W1997251454 crossrefType "journal-article" @default.
- W1997251454 hasAuthorship W1997251454A5036328741 @default.
- W1997251454 hasAuthorship W1997251454A5067289994 @default.
- W1997251454 hasConcept C104317684 @default.
- W1997251454 hasConcept C10730799 @default.
- W1997251454 hasConcept C119795356 @default.
- W1997251454 hasConcept C140137476 @default.
- W1997251454 hasConcept C148738053 @default.
- W1997251454 hasConcept C179402230 @default.
- W1997251454 hasConcept C181199279 @default.
- W1997251454 hasConcept C184235292 @default.
- W1997251454 hasConcept C185592680 @default.
- W1997251454 hasConcept C190098323 @default.
- W1997251454 hasConcept C20251656 @default.
- W1997251454 hasConcept C2780854706 @default.
- W1997251454 hasConcept C55493867 @default.
- W1997251454 hasConcept C86803240 @default.
- W1997251454 hasConcept C9506865 @default.
- W1997251454 hasConcept C95444343 @default.
- W1997251454 hasConceptScore W1997251454C104317684 @default.
- W1997251454 hasConceptScore W1997251454C10730799 @default.
- W1997251454 hasConceptScore W1997251454C119795356 @default.
- W1997251454 hasConceptScore W1997251454C140137476 @default.
- W1997251454 hasConceptScore W1997251454C148738053 @default.
- W1997251454 hasConceptScore W1997251454C179402230 @default.
- W1997251454 hasConceptScore W1997251454C181199279 @default.
- W1997251454 hasConceptScore W1997251454C184235292 @default.
- W1997251454 hasConceptScore W1997251454C185592680 @default.
- W1997251454 hasConceptScore W1997251454C190098323 @default.
- W1997251454 hasConceptScore W1997251454C20251656 @default.
- W1997251454 hasConceptScore W1997251454C2780854706 @default.
- W1997251454 hasConceptScore W1997251454C55493867 @default.
- W1997251454 hasConceptScore W1997251454C86803240 @default.
- W1997251454 hasConceptScore W1997251454C9506865 @default.
- W1997251454 hasConceptScore W1997251454C95444343 @default.
- W1997251454 hasIssue "1" @default.
- W1997251454 hasLocation W19972514541 @default.
- W1997251454 hasLocation W19972514542 @default.
- W1997251454 hasOpenAccess W1997251454 @default.
- W1997251454 hasPrimaryLocation W19972514541 @default.
- W1997251454 hasRelatedWork W1573453758 @default.
- W1997251454 hasRelatedWork W1872726919 @default.
- W1997251454 hasRelatedWork W1976971588 @default.
- W1997251454 hasRelatedWork W1996258182 @default.
- W1997251454 hasRelatedWork W2006037499 @default.
- W1997251454 hasRelatedWork W2038514978 @default.
- W1997251454 hasRelatedWork W2057561370 @default.
- W1997251454 hasRelatedWork W2062710282 @default.
- W1997251454 hasRelatedWork W2189074676 @default.
- W1997251454 hasRelatedWork W2322483951 @default.
- W1997251454 hasVolume "23" @default.
- W1997251454 isParatext "false" @default.
- W1997251454 isRetracted "false" @default.
- W1997251454 magId "1997251454" @default.
- W1997251454 workType "article" @default.