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• W1997251501 endingPage "63" @default.
• W1997251501 startingPage "45" @default.
• W1997251501 abstract "All crystal structures of A-DNA duplexes exhibit a typical crystal packing, with the termini of one molecule abutting the shallow grooves of symmetry related neighbors, while all other forms (B, Z, and RNA) tend to form infinitely stacked helices. The A-DNA arrangement leads to the formation of shallow groove base multiples that have implications for the structure of DNA in compacted states. The characteristic packing leaves big solvent channels, which can be sometimes occupied by B-DNA duplexes. Comparisons of the structures of the same oligomer crystallizing in two different space groups and of different sequences crystallizing in the same space group show that the lattice forces dominate the A-DNA conformation in the crystals, complicating the effort to elucidate the influence of the base sequence on the structures. Nevertheless, in both alternating and nonalternating fragments some sequence effects can still be uncovered. Furthermore, several studies have started to define the minimal sequence changes or chemical modifications that can interconvert the oligomers between different double-helical conformers (A-, B-, and Z-form). Overall, it is seen that the rigid nucleotide principle applies to the oligomeric fragments. Besides the structures of the naked DNAs, their interactions with water, polyamines, and metal ions have attracted considerable attention. There are conserved patterns in the hydration, involving both the grooves and the backbone, which are different from those of B-DNA or Z-DNA. Overall, A-DNA seems to be more economically hydrated than B-DNA, particularly around the sugar-phosphate backbone. Spermine was found to be able to bind exclusively to either of the grooves or to the phosphate groups of the backbone, or exhibit a mixed binding mode. The located metal cations prefer binding to guanine bases and phosphate groups. The only mispairs investigated in A-DNA are the wobble pairs, yielding structural insight into their effects on helix stabilities and hydration. G.T wobble pairs have been determined in various sequence contexts, where they differentially affect the conformations and stableness of the duplexes. The structure of a G.m5C base pair, which surprisingly also adopted the wobble conformation, suggests that a similar geometry may transiently exist for G.C pairs. These results from the crystalline state will be compared to the solution state and discussed in relation to their relevance in biology." @default.
• W1997251501 created "2016-06-24" @default.
• W1997251501 creator A5052692229 @default.
• W1997251501 creator A5070934576 @default.
• W1997251501 date "1997-01-01" @default.
• W1997251501 modified "2023-10-14" @default.
• W1997251501 title "Crystal structures of A‐DNA duplexes" @default.
• W1997251501 cites W1495212756 @default.
• W1997251501 cites W1526944695 @default.
• W1997251501 cites W1538319924 @default.
• W1997251501 cites W1571881198 @default.
• W1997251501 cites W1575649761 @default.
• W1997251501 cites W1577332561 @default.
• W1997251501 cites W1582727954 @default.
• W1997251501 cites W1852535752 @default.
• W1997251501 cites W1969776708 @default.
• W1997251501 cites W1970429992 @default.
• W1997251501 cites W1971440591 @default.
• W1997251501 cites W1971729824 @default.
• W1997251501 cites W1972570207 @default.
• W1997251501 cites W1973500838 @default.
• W1997251501 cites W1973503110 @default.
• W1997251501 cites W1975700737 @default.
• W1997251501 cites W1975842318 @default.
• W1997251501 cites W1976409387 @default.
• W1997251501 cites W1979445596 @default.
• W1997251501 cites W1981571687 @default.
• W1997251501 cites W1988841752 @default.
• W1997251501 cites W1988977198 @default.
• W1997251501 cites W1990849098 @default.
• W1997251501 cites W1990933742 @default.
• W1997251501 cites W1996294655 @default.
• W1997251501 cites W2003122343 @default.
• W1997251501 cites W2004193311 @default.
• W1997251501 cites W2008758554 @default.
• W1997251501 cites W2011052937 @default.
• W1997251501 cites W2012681128 @default.
• W1997251501 cites W2015261322 @default.
• W1997251501 cites W2018093694 @default.
• W1997251501 cites W2018108450 @default.
• W1997251501 cites W2019296317 @default.
• W1997251501 cites W2019362220 @default.
• W1997251501 cites W2020784329 @default.
• W1997251501 cites W2021527787 @default.
• W1997251501 cites W2023032661 @default.
• W1997251501 cites W2024224587 @default.
• W1997251501 cites W2030677298 @default.
• W1997251501 cites W2031775631 @default.
• W1997251501 cites W2032762879 @default.
• W1997251501 cites W2032864324 @default.
• W1997251501 cites W2035186580 @default.
• W1997251501 cites W2035797443 @default.
• W1997251501 cites W2037706894 @default.
• W1997251501 cites W2038885509 @default.
• W1997251501 cites W2050843661 @default.
• W1997251501 cites W2051606490 @default.
• W1997251501 cites W2053018494 @default.
• W1997251501 cites W2053561906 @default.
• W1997251501 cites W2054207735 @default.
• W1997251501 cites W2055671081 @default.
• W1997251501 cites W2055720064 @default.
• W1997251501 cites W2055852879 @default.
• W1997251501 cites W2055981673 @default.
• W1997251501 cites W2056365723 @default.
• W1997251501 cites W2056699459 @default.
• W1997251501 cites W2057163818 @default.
• W1997251501 cites W2057792633 @default.
• W1997251501 cites W2062326564 @default.
• W1997251501 cites W2063310584 @default.
• W1997251501 cites W2068694787 @default.
• W1997251501 cites W2071504229 @default.
• W1997251501 cites W2078085951 @default.
• W1997251501 cites W2079098391 @default.
• W1997251501 cites W2081292115 @default.
• W1997251501 cites W2085965241 @default.
• W1997251501 cites W2086561929 @default.
• W1997251501 cites W2086662845 @default.
• W1997251501 cites W2087431455 @default.
• W1997251501 cites W2087721492 @default.
• W1997251501 cites W2092084554 @default.
• W1997251501 cites W2104042038 @default.
• W1997251501 cites W2110534779 @default.
• W1997251501 cites W2117589933 @default.
• W1997251501 cites W2120759979 @default.
• W1997251501 cites W2123951763 @default.
• W1997251501 cites W2124582467 @default.
• W1997251501 cites W2126048482 @default.
• W1997251501 cites W2127387121 @default.
• W1997251501 cites W2130681953 @default.
• W1997251501 cites W2139815425 @default.
• W1997251501 cites W2141542177 @default.
• W1997251501 cites W2147562836 @default.
• W1997251501 cites W4252060880 @default.
• W1997251501 doi "https://doi.org/10.1002/(sici)1097-0282(1997)44:1<45::aid-bip4>3.0.co;2-#" @default.
• W1997251501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9097733" @default.
• W1997251501 hasPublicationYear "1997" @default.
• W1997251501 type Work @default.
• W1997251501 sameAs 1997251501 @default.

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