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- W1997256271 abstract "Lycopene is primarily metabolized by carotenoid monoxygenase II into apo-8′- and apo-12′-lycopenal in the rat liver. Although lycopene possesses antimetastatic activity in a highly invasive hepatoma SK-Hep-1 cell line, little is known whether its metabolites have a similar effect. In this study, we investigated the antimetastatic effects of apo-8′-lycopenal (1–10 μM) in comparison with lycopene (10 μM) in SK-Hep-1 cells. We found that both apo-8′-lycopenal and lycopene inhibited the invasion and migration of SK-Hep-1 cells, and the effect of apo-8′-lycopenal was stronger than that of lycopene at the same concentration (10 μM). Mechanistically, apo-8′-lycopenal: 1) decreased the activities and protein expression of metalloproteinase-2 (MMP-2) and −9; 2) increased the protein expression of nm23-H1 and the tissue inhibitor of MMP (TIMP)-1 and −2; 3) suppressed protein expression of Rho small GTPases; and 4) inhibited focal adhesion kinase-mediated signaling pathway, such as ERK/p38 and PI3K-Akt axis. Overall, these results demonstrate that apo-8′-lycopenal possesses antimetastatic activity in SK-Hep-1 cells and that this effect is stronger than that of lycopene, suggesting that the antimetastatic effect may be attributed, at least in part, to its metabolites such as apo-8′-lycopenal." @default.
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- W1997256271 date "2012-02-01" @default.
- W1997256271 modified "2023-09-26" @default.
- W1997256271 title "Antimetastatic Effects and Mechanisms of Apo-8′-Lycopenal, an Enzymatic Metabolite of Lycopene, Against Human Hepatocarcinoma SK-Hep-1 Cells" @default.
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- W1997256271 doi "https://doi.org/10.1080/01635581.2012.643273" @default.
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