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- W1997269770 abstract "One-electron oxidation of duplex DNA generates a radical cation that migrates through the nucleobases until it is trapped by an irreversible reaction with water or oxygen. The trapping site is often a GG step, because this site has a relatively low ionization potential and this causes the radical cation to pause there momentarily. Modifications to guanine that lower its ionization potential convert it to a better trap for the radical cation. One such modification is the formation of the Watson−Crick base pair with cytosine, which is reported to very significantly decrease its ionization potential. Methylation of cytosine to form 5-methylcytosine (5-MeC) is a naturally occurring reaction in genomic DNA that may be associated with regions of enhanced oxidative damage. The G·5-MeC base pair is reported to be more rapidly oxidized than normal G·C base pairs. We examined the oxidation of DNA oligomers that were substituted in part with 5-MeC. Irradiation of a covalently linked anthraquinone group injects a radical cation into the DNA and results in strand cleavage after piperidine treatment. For the sequences examined, substitution of 5-MeC for C has no measurable effect on the reactions. Cytosine methylation is not a general cause of enhanced oxidative damage in DNA." @default.
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- W1997269770 date "2004-05-25" @default.
- W1997269770 modified "2023-09-27" @default.
- W1997269770 title "One-Electron Oxidation of DNA: The Effect of Replacement of Cytosine with 5-Methylcytosine on Long-Distance Radical Cation Transport and Reaction" @default.
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- W1997269770 doi "https://doi.org/10.1021/ja049468i" @default.
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