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• W1997286179 abstract "This study evaluates the mechanisms underlying endothelium-dependent responses to acetylcholine in horse deep dorsal penile veins. Acetylcholine-induced relaxation was abolished by endothelium removal, the soluble guanylyl cyclase-inhibitor, and the nitric oxide (NO) synthase inhibitors. Acetylcholine-induced relaxation was inhibited by high K+ concentrations and blockade of large-conductance Ca2+-activated potassium (BKCa) channels, and voltage-dependent potassium (Kv) channels. Relaxations were unaffected by a small-conductance KCa (SKCa) channel blocker, or an ATP-sensitive potassium (KATP) channel blocker. Relaxation in response to a NO donor was unaffected by KCa channel blockers, but inhibited by high K+ concentrations and a Kv channel blocker. In the presence of a NO synthase inhibitor, acetylcholine-induced contractions were inhibited by a cyclooxygenase blocker and abolished by endothelial removal. The contractile response was competitively inhibited by muscarinic receptor antagonists, high affinity M1 and M3 antagonists, while the M2 antagonist had no effect. The pharmacological profile suggests that acetylcholine contraction is mediated by muscarinic M1 receptors. Our findings indicate that acetylcholine-induced relaxation in the horse deep dorsal penile vein is essentially mediated by NO, acting via the cGMP-dependent pathway and opening of K+ channels. The contraction elicited by acetylcholine is prostanoid-mediated and induced by endothelial muscarinic M1 receptor activation." @default.
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• W1997286179 date "2005-05-01" @default.
• W1997286179 modified "2023-10-18" @default.
• W1997286179 title "Endothelial mechanisms underlying responses to acetylcholine in the horse deep dorsal penile vein" @default.
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• W1997286179 doi "https://doi.org/10.1016/j.ejphar.2005.04.012" @default.
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