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- W1997295622 abstract "Antigenic variation in Trypanosoma brucei is a highly sophisticated survival strategy involving switching between the transcription of one of an estimated thousand variant surface glycoprotein (VSG) genes. Switching involves either transcriptional control, resulting in switching between different VSG expression sites; or DNA rearrangement events slotting previously inactive VSG genes into an active VSG expression site. In recent years, considerable progress has been made in techniques allowing us to genetically modify infective bloodstream form trypanosomes. This is allowing us to reengineer VSG expression sites, and look at the effect on the mechanisms subsequently used for antigenic variation. We can now begin a dissection of a highly complicated survival strategy mediated by many different mechanisms operating simultaneously." @default.
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- W1997295622 date "1999-03-01" @default.
- W1997295622 modified "2023-10-18" @default.
- W1997295622 title "Mechanisms Mediating Antigenic Variation in Trypanosoma brucei" @default.
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- W1997295622 doi "https://doi.org/10.1590/s0074-02761999000200021" @default.
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