Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997299931> ?p ?o ?g. }
- W1997299931 endingPage "453" @default.
- W1997299931 startingPage "437" @default.
- W1997299931 abstract "Antibody drugs have become an increasingly significant component of the therapeutic landscape. Their success has been driven by some of their unique properties, in particular their very high specificity and selectivity, in contrast to the off-target liabilities of small molecules (SMs). Antibodies can bring additional functionality to the table with their ability to interact with the immune system, and this can be further manipulated with advances in antibody engineering. This review summarizes what antibody therapeutics have achieved to date and what opportunities and challenges lie ahead. The target landscape for large molecules (LMs) versus SMs and some of the challenges for antibody drug development are discussed. Effective penetration of membrane barriers and intracellular targeting is one challenge, particularly across the highly resistant blood-brain barrier. The expanding pipeline of antibody-drug conjugates offers the potential to combine SM and LM modalities in a variety of creative ways, and antibodies also offer exciting potential to build bi- and multispecific molecules. The ability to pursue more challenging targets can also be further exploited but highlights the need for earlier screening in functional cell-based assays. I discuss how this might be addressed given the practical constraints imposed by high-throughput screening sample type and process differences in antibody primary screening." @default.
- W1997299931 created "2016-06-24" @default.
- W1997299931 creator A5069961351 @default.
- W1997299931 date "2015-04-01" @default.
- W1997299931 modified "2023-10-09" @default.
- W1997299931 title "New Horizons in Therapeutic Antibody Discovery: Opportunities and Challenges versus Small-Molecule Therapeutics" @default.
- W1997299931 cites W1500469260 @default.
- W1997299931 cites W1503491996 @default.
- W1997299931 cites W1530464231 @default.
- W1997299931 cites W1535069478 @default.
- W1997299931 cites W1538622944 @default.
- W1997299931 cites W1551220004 @default.
- W1997299931 cites W1555095384 @default.
- W1997299931 cites W1583907074 @default.
- W1997299931 cites W1589255464 @default.
- W1997299931 cites W1839513988 @default.
- W1997299931 cites W1847500897 @default.
- W1997299931 cites W1965759044 @default.
- W1997299931 cites W1965878517 @default.
- W1997299931 cites W1966430295 @default.
- W1997299931 cites W1966885906 @default.
- W1997299931 cites W1967624191 @default.
- W1997299931 cites W1967776111 @default.
- W1997299931 cites W1970663569 @default.
- W1997299931 cites W1973544766 @default.
- W1997299931 cites W1976946513 @default.
- W1997299931 cites W1978965418 @default.
- W1997299931 cites W1979498341 @default.
- W1997299931 cites W1979525201 @default.
- W1997299931 cites W1980308557 @default.
- W1997299931 cites W1980446197 @default.
- W1997299931 cites W1982043116 @default.
- W1997299931 cites W1982183807 @default.
- W1997299931 cites W1982413610 @default.
- W1997299931 cites W1983252783 @default.
- W1997299931 cites W1983386052 @default.
- W1997299931 cites W1983705094 @default.
- W1997299931 cites W1984107341 @default.
- W1997299931 cites W1985129922 @default.
- W1997299931 cites W1987002349 @default.
- W1997299931 cites W1987534225 @default.
- W1997299931 cites W1987913042 @default.
- W1997299931 cites W1990319260 @default.
- W1997299931 cites W1990461661 @default.
- W1997299931 cites W1991936310 @default.
- W1997299931 cites W1992175481 @default.
- W1997299931 cites W1993071007 @default.
- W1997299931 cites W1993575340 @default.
- W1997299931 cites W1994506288 @default.
- W1997299931 cites W1995239905 @default.
- W1997299931 cites W1995351026 @default.
- W1997299931 cites W1995923662 @default.
- W1997299931 cites W1996323606 @default.
- W1997299931 cites W1996820981 @default.
- W1997299931 cites W2000521278 @default.
- W1997299931 cites W2001663735 @default.
- W1997299931 cites W2003052374 @default.
- W1997299931 cites W2003378333 @default.
- W1997299931 cites W2003630280 @default.
- W1997299931 cites W2005137753 @default.
- W1997299931 cites W2005600404 @default.
- W1997299931 cites W2005671985 @default.
- W1997299931 cites W2005970620 @default.
- W1997299931 cites W2006661094 @default.
- W1997299931 cites W2006968970 @default.
- W1997299931 cites W2007128488 @default.
- W1997299931 cites W2007141443 @default.
- W1997299931 cites W2007626882 @default.
- W1997299931 cites W2007906244 @default.
- W1997299931 cites W2008028087 @default.
- W1997299931 cites W2010739774 @default.
- W1997299931 cites W2011964198 @default.
- W1997299931 cites W2020052113 @default.
- W1997299931 cites W2021067723 @default.
- W1997299931 cites W2021622275 @default.
- W1997299931 cites W2021865808 @default.
- W1997299931 cites W2023442955 @default.
- W1997299931 cites W2023733169 @default.
- W1997299931 cites W2023765040 @default.
- W1997299931 cites W2024992774 @default.
- W1997299931 cites W2026836992 @default.
- W1997299931 cites W2028489386 @default.
- W1997299931 cites W2028820426 @default.
- W1997299931 cites W2029209789 @default.
- W1997299931 cites W2030177226 @default.
- W1997299931 cites W2030522563 @default.
- W1997299931 cites W2031135203 @default.
- W1997299931 cites W2032185672 @default.
- W1997299931 cites W2034287217 @default.
- W1997299931 cites W2036032993 @default.
- W1997299931 cites W2037411233 @default.
- W1997299931 cites W2037571189 @default.
- W1997299931 cites W2037664321 @default.
- W1997299931 cites W2039928024 @default.
- W1997299931 cites W2041393833 @default.
- W1997299931 cites W2042717319 @default.
- W1997299931 cites W2042786738 @default.
- W1997299931 cites W2046486142 @default.