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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997307027> ?p ?o ?g. }

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• W1997307027 abstract "Novel indole-3-heterocycles were designed and synthesized and found to be potent CB1 receptor agonists. Starting from a microsomally unstable lead 1, a bioisostere approach replacing a piperazine amide was undertaken. This was found to be a good strategy for improving stability both in vitro and in vivo. This led to the discovery of 24, which had an increased duration of action in the mouse tail flick test in comparison to the lead 1." @default.
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• W1997307027 date "2011-01-01" @default.
• W1997307027 modified "2023-09-27" @default.
• W1997307027 title "Design, synthesis, and structure–activity relationships of indole-3-heterocycles as agonists of the CB1 receptor" @default.
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• W1997307027 doi "https://doi.org/10.1016/j.bmcl.2010.10.093" @default.
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