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• W1997307989 endingPage "950" @default.
• W1997307989 startingPage "926" @default.
• W1997307989 abstract "The endoplasmic reticulum (ER) is the site of secretory protein biogenesis. The ER quality control (QC) machinery, including chaperones, ensures the correct folding of secretory proteins. Mutant proteins and environmental stresses can overwhelm the available QC machinery. To prevent and resolve accumulation of misfolded secretory proteins in the ER, cells have evolved integral membrane sensors that orchestrate the Unfolded Protein Response (UPR). The sensors, Ire1p in yeast and IRE1, ATF6, and PERK in metazoans, bind the luminal ER chaperone BiP during homeostasis. As unfolded secretory proteins accumulate in the ER lumen, BiP releases, and the sensors activate. The mechanisms of activation and attenuation of the UPR sensors have exhibited unexpected complexity. A growing body of data supports a model in which Ire1p, and potentially IRE1, directly bind unfolded proteins as part of the activation process. However, evidence for an unfolded protein-independent mechanism has recently emerged, suggesting that UPR can be activated by multiple modes. Importantly, dysregulation of the UPR has been linked to human diseases including Type II diabetes, heart disease, and cancer. The existence of alternative regulatory pathways for UPR sensors raises the exciting possibility for the development of new classes of therapeutics for these medically important proteins." @default.
• W1997307989 created "2016-06-24" @default.
• W1997307989 creator A5009271793 @default.
• W1997307989 date "2012-11-01" @default.
• W1997307989 modified "2023-09-24" @default.
• W1997307989 title "Unfolded Protein Responses With or Without Unfolded Proteins?" @default.
• W1997307989 cites W1546139069 @default.
• W1997307989 cites W1569469862 @default.
• W1997307989 cites W1575156763 @default.
• W1997307989 cites W1585555029 @default.
• W1997307989 cites W17493816 @default.
• W1997307989 cites W1765185969 @default.
• W1997307989 cites W1967786181 @default.
• W1997307989 cites W1970090817 @default.
• W1997307989 cites W1971108880 @default.
• W1997307989 cites W1972482541 @default.
• W1997307989 cites W1974854199 @default.
• W1997307989 cites W1975646305 @default.
• W1997307989 cites W1976161806 @default.
• W1997307989 cites W1977603207 @default.
• W1997307989 cites W1978490927 @default.
• W1997307989 cites W1986290768 @default.
• W1997307989 cites W1987587007 @default.
• W1997307989 cites W1988482079 @default.
• W1997307989 cites W1990136127 @default.
• W1997307989 cites W1990400035 @default.
• W1997307989 cites W1993697882 @default.
• W1997307989 cites W1993777187 @default.
• W1997307989 cites W1996785364 @default.
• W1997307989 cites W2001399725 @default.
• W1997307989 cites W2003278197 @default.
• W1997307989 cites W2007598683 @default.
• W1997307989 cites W2009653694 @default.
• W1997307989 cites W2013947447 @default.
• W1997307989 cites W2015221600 @default.
• W1997307989 cites W2018548331 @default.
• W1997307989 cites W2020437934 @default.
• W1997307989 cites W2021028081 @default.
• W1997307989 cites W2027291842 @default.
• W1997307989 cites W2028603831 @default.
• W1997307989 cites W2028878583 @default.
• W1997307989 cites W2030574146 @default.
• W1997307989 cites W2036355941 @default.
• W1997307989 cites W2037050530 @default.
• W1997307989 cites W2038763220 @default.
• W1997307989 cites W2040080953 @default.
• W1997307989 cites W2040993603 @default.
• W1997307989 cites W2042232940 @default.
• W1997307989 cites W2042294920 @default.
• W1997307989 cites W2042688172 @default.
• W1997307989 cites W2046640957 @default.
• W1997307989 cites W2047498253 @default.
• W1997307989 cites W2048456744 @default.
• W1997307989 cites W2049190436 @default.
• W1997307989 cites W2052321340 @default.
• W1997307989 cites W2052586663 @default.
• W1997307989 cites W2053535274 @default.
• W1997307989 cites W2055836716 @default.
• W1997307989 cites W2056592058 @default.
• W1997307989 cites W2058357801 @default.
• W1997307989 cites W2060084781 @default.
• W1997307989 cites W2062918974 @default.
• W1997307989 cites W2067018477 @default.
• W1997307989 cites W2070563559 @default.
• W1997307989 cites W2071002178 @default.
• W1997307989 cites W2075892193 @default.
• W1997307989 cites W2077026981 @default.
• W1997307989 cites W2078700501 @default.
• W1997307989 cites W2080657452 @default.
• W1997307989 cites W2081731224 @default.
• W1997307989 cites W2082001606 @default.
• W1997307989 cites W2083445344 @default.
• W1997307989 cites W2085045544 @default.
• W1997307989 cites W2087221130 @default.
• W1997307989 cites W2087618734 @default.
• W1997307989 cites W2089198803 @default.
• W1997307989 cites W2089787026 @default.
• W1997307989 cites W2095139331 @default.
• W1997307989 cites W2096947423 @default.
• W1997307989 cites W2098365491 @default.
• W1997307989 cites W2100991511 @default.
• W1997307989 cites W2101358807 @default.
• W1997307989 cites W2102824402 @default.
• W1997307989 cites W2103334789 @default.
• W1997307989 cites W2105556300 @default.
• W1997307989 cites W2105854542 @default.
• W1997307989 cites W2106983618 @default.
• W1997307989 cites W2108812454 @default.
• W1997307989 cites W2111587627 @default.
• W1997307989 cites W2114676656 @default.
• W1997307989 cites W2114746301 @default.
• W1997307989 cites W2115070143 @default.
• W1997307989 cites W2123642481 @default.
• W1997307989 cites W2125253481 @default.
• W1997307989 cites W2127848114 @default.
• W1997307989 cites W2127906377 @default.
• W1997307989 cites W2128551987 @default.
• W1997307989 cites W2129312201 @default.

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