FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997319030> ?p ?o ?g. }

• W1997319030 endingPage "2916" @default.
• W1997319030 startingPage "2904" @default.
• W1997319030 abstract "Human RECQL5 is a member of the RecQ helicase family which is implicated in genome maintenance. Five human members of the family have been identified; three of them, BLM, WRN and RECQL4 are associated with elevated cancer risk. RECQL1 and RECQL5 have not been linked to any human disorder yet; cells devoid of RECQL1 and RECQL5 display increased chromosomal instability. Here, we report the physical and functional interaction of the large isomer of RECQL5, RECQL5β, with the human flap endonuclease 1, FEN1, which plays a critical role in DNA replication, recombination and repair. RECQL5β dramatically stimulates the rate of FEN1 cleavage of flap DNA substrates. Moreover, we show that RECQL5β and FEN1 interact physically and co-localize in the nucleus in response to DNA damage. Our findings, together with the previous literature on WRN, BLM and RECQL4's stimulation of FEN1, suggests that the ability of RecQ helicases to stimulate FEN1 may be a general feature of this class of enzymes. This could indicate a common role for the RecQ helicases in the processing of oxidative DNA damage." @default.
• W1997319030 created "2016-06-24" @default.
• W1997319030 creator A5017796398 @default.
• W1997319030 creator A5021951971 @default.
• W1997319030 creator A5025085285 @default.
• W1997319030 creator A5028234120 @default.
• W1997319030 creator A5046044982 @default.
• W1997319030 creator A5052167622 @default.
• W1997319030 creator A5055646108 @default.
• W1997319030 creator A5083783456 @default.
• W1997319030 creator A5089917586 @default.
• W1997319030 date "2010-01-16" @default.
• W1997319030 modified "2023-09-26" @default.
• W1997319030 title "Human RECQL5β stimulates flap endonuclease 1" @default.
• W1997319030 cites W1860417382 @default.
• W1997319030 cites W1935801587 @default.
• W1997319030 cites W1967209251 @default.
• W1997319030 cites W1967634425 @default.
• W1997319030 cites W1973194906 @default.
• W1997319030 cites W1973695147 @default.
• W1997319030 cites W1983271010 @default.
• W1997319030 cites W1994232734 @default.
• W1997319030 cites W1995390673 @default.
• W1997319030 cites W1996873024 @default.
• W1997319030 cites W2001193188 @default.
• W1997319030 cites W2003329456 @default.
• W1997319030 cites W2005448675 @default.
• W1997319030 cites W2009024472 @default.
• W1997319030 cites W2015378640 @default.
• W1997319030 cites W2019044101 @default.
• W1997319030 cites W2020390201 @default.
• W1997319030 cites W2021483139 @default.
• W1997319030 cites W2021819391 @default.
• W1997319030 cites W2022547913 @default.
• W1997319030 cites W2025180999 @default.
• W1997319030 cites W2028513756 @default.
• W1997319030 cites W2030639168 @default.
• W1997319030 cites W2033229710 @default.
• W1997319030 cites W2033676950 @default.
• W1997319030 cites W2035561771 @default.
• W1997319030 cites W2036301524 @default.
• W1997319030 cites W2041840396 @default.
• W1997319030 cites W2046175921 @default.
• W1997319030 cites W2056166567 @default.
• W1997319030 cites W2060672912 @default.
• W1997319030 cites W2064310741 @default.
• W1997319030 cites W2064477710 @default.
• W1997319030 cites W2064694917 @default.
• W1997319030 cites W2066253067 @default.
• W1997319030 cites W2076684390 @default.
• W1997319030 cites W2082217198 @default.
• W1997319030 cites W2085312575 @default.
• W1997319030 cites W2086401125 @default.
• W1997319030 cites W2099958026 @default.
• W1997319030 cites W2100626549 @default.
• W1997319030 cites W2102923747 @default.
• W1997319030 cites W2111202021 @default.
• W1997319030 cites W2118764522 @default.
• W1997319030 cites W2119245063 @default.
• W1997319030 cites W2123235480 @default.
• W1997319030 cites W2123557271 @default.
• W1997319030 cites W2131980596 @default.
• W1997319030 cites W2133369866 @default.
• W1997319030 cites W2133839705 @default.
• W1997319030 cites W2134480031 @default.
• W1997319030 cites W2142485616 @default.
• W1997319030 cites W2159157712 @default.
• W1997319030 cites W2168019500 @default.
• W1997319030 cites W2169553212 @default.
• W1997319030 cites W4249952782 @default.
• W1997319030 doi "https://doi.org/10.1093/nar/gkp1217" @default.
• W1997319030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2875029" @default.
• W1997319030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20081208" @default.
• W1997319030 hasPublicationYear "2010" @default.
• W1997319030 type Work @default.
• W1997319030 sameAs 1997319030 @default.
• W1997319030 citedByCount "20" @default.
• W1997319030 countsByYear W19973190302012 @default.
• W1997319030 countsByYear W19973190302013 @default.
• W1997319030 countsByYear W19973190302014 @default.
• W1997319030 countsByYear W19973190302015 @default.
• W1997319030 countsByYear W19973190302016 @default.
• W1997319030 countsByYear W19973190302017 @default.
• W1997319030 countsByYear W19973190302020 @default.
• W1997319030 crossrefType "journal-article" @default.
• W1997319030 hasAuthorship W1997319030A5017796398 @default.
• W1997319030 hasAuthorship W1997319030A5021951971 @default.
• W1997319030 hasAuthorship W1997319030A5025085285 @default.
• W1997319030 hasAuthorship W1997319030A5028234120 @default.
• W1997319030 hasAuthorship W1997319030A5046044982 @default.
• W1997319030 hasAuthorship W1997319030A5052167622 @default.
• W1997319030 hasAuthorship W1997319030A5055646108 @default.
• W1997319030 hasAuthorship W1997319030A5083783456 @default.
• W1997319030 hasAuthorship W1997319030A5089917586 @default.
• W1997319030 hasBestOaLocation W19973190302 @default.
• W1997319030 hasConcept C104317684 @default.
• W1997319030 hasConcept C134935766 @default.
• W1997319030 hasConcept C143425029 @default.

• next