FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997334984> ?p ?o ?g. }

• W1997334984 endingPage "613" @default.
• W1997334984 startingPage "603" @default.
• W1997334984 abstract "The members of the epidermal growth factor receptor (EGFR) family are over expressed in a variety of malignancies and are frequently linked to aggressive disease and a poor prognosis. Although clinically effective monoclonal antibodies (MAbs) have been developed to target HER2 and EGFR, the remaining two family members, HER3 and HER4, have not been the subject of significant efforts. In this paper, we have taken the initial steps required to generate antibodies with potential clinically utility that target the members of the EGFR family. The genes for the extracellular domains (ECDs) of all four members of the EGFR family were cloned and used to stably transfect 293 (HEK) cells. Milligram quantities of each ECD were produced and characterized. The HER3, HER4, and EGFR ECDs were then employed as targets for the selection of antibodies from naïve human scFv (single-chain Fv) phage display libraries. Six unique scFv clones were isolated that bound specifically to HER3, 13 unique clones were isolated with specificity for HER4 and 52 unique anti-EGFR clones were isolated. These scFvs provide a valuable and potentially clinically relevant panel of agents to target the members of the EGFR family." @default.
• W1997334984 created "2016-06-24" @default.
• W1997334984 creator A5001175777 @default.
• W1997334984 creator A5002421037 @default.
• W1997334984 creator A5007026706 @default.
• W1997334984 creator A5023191140 @default.
• W1997334984 creator A5023229126 @default.
• W1997334984 creator A5036175382 @default.
• W1997334984 creator A5038349275 @default.
• W1997334984 creator A5042455836 @default.
• W1997334984 creator A5042756187 @default.
• W1997334984 creator A5044830720 @default.
• W1997334984 creator A5045107557 @default.
• W1997334984 creator A5056337957 @default.
• W1997334984 creator A5084770334 @default.
• W1997334984 date "2005-12-01" @default.
• W1997334984 modified "2023-10-18" @default.
• W1997334984 title "Isolation of scFvs to<i>In Vitro</i>Produced Extracellular Domains of EGFR Family Members" @default.
• W1997334984 cites W1512026049 @default.
• W1997334984 cites W1531785323 @default.
• W1997334984 cites W1549258100 @default.
• W1997334984 cites W1601571585 @default.
• W1997334984 cites W1964321121 @default.
• W1997334984 cites W1982729445 @default.
• W1997334984 cites W1986723482 @default.
• W1997334984 cites W1996372431 @default.
• W1997334984 cites W1996820981 @default.
• W1997334984 cites W2006013401 @default.
• W1997334984 cites W2013285346 @default.
• W1997334984 cites W2014582878 @default.
• W1997334984 cites W2016103121 @default.
• W1997334984 cites W2022507641 @default.
• W1997334984 cites W2030522563 @default.
• W1997334984 cites W2048599407 @default.
• W1997334984 cites W2050105922 @default.
• W1997334984 cites W2058586537 @default.
• W1997334984 cites W2062366098 @default.
• W1997334984 cites W2068395370 @default.
• W1997334984 cites W2069526613 @default.
• W1997334984 cites W2077374035 @default.
• W1997334984 cites W2096214890 @default.
• W1997334984 cites W2141393790 @default.
• W1997334984 cites W2143651667 @default.
• W1997334984 cites W2154216619 @default.
• W1997334984 cites W2165003903 @default.
• W1997334984 cites W2165845069 @default.
• W1997334984 cites W4236694078 @default.
• W1997334984 cites W4254635893 @default.
• W1997334984 doi "https://doi.org/10.1089/cbr.2005.20.603" @default.
• W1997334984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16398612" @default.
• W1997334984 hasPublicationYear "2005" @default.
• W1997334984 type Work @default.
• W1997334984 sameAs 1997334984 @default.
• W1997334984 citedByCount "31" @default.
• W1997334984 countsByYear W19973349842012 @default.
• W1997334984 countsByYear W19973349842013 @default.
• W1997334984 countsByYear W19973349842014 @default.
• W1997334984 countsByYear W19973349842015 @default.
• W1997334984 countsByYear W19973349842016 @default.
• W1997334984 countsByYear W19973349842017 @default.
• W1997334984 countsByYear W19973349842019 @default.
• W1997334984 countsByYear W19973349842020 @default.
• W1997334984 crossrefType "journal-article" @default.
• W1997334984 hasAuthorship W1997334984A5001175777 @default.
• W1997334984 hasAuthorship W1997334984A5002421037 @default.
• W1997334984 hasAuthorship W1997334984A5007026706 @default.
• W1997334984 hasAuthorship W1997334984A5023191140 @default.
• W1997334984 hasAuthorship W1997334984A5023229126 @default.
• W1997334984 hasAuthorship W1997334984A5036175382 @default.
• W1997334984 hasAuthorship W1997334984A5038349275 @default.
• W1997334984 hasAuthorship W1997334984A5042455836 @default.
• W1997334984 hasAuthorship W1997334984A5042756187 @default.
• W1997334984 hasAuthorship W1997334984A5044830720 @default.
• W1997334984 hasAuthorship W1997334984A5045107557 @default.
• W1997334984 hasAuthorship W1997334984A5056337957 @default.
• W1997334984 hasAuthorship W1997334984A5084770334 @default.
• W1997334984 hasConcept C104317684 @default.
• W1997334984 hasConcept C153911025 @default.
• W1997334984 hasConcept C159047783 @default.
• W1997334984 hasConcept C159654299 @default.
• W1997334984 hasConcept C170493617 @default.
• W1997334984 hasConcept C174510640 @default.
• W1997334984 hasConcept C186268636 @default.
• W1997334984 hasConcept C202751555 @default.
• W1997334984 hasConcept C2779438470 @default.
• W1997334984 hasConcept C28406088 @default.
• W1997334984 hasConcept C502942594 @default.
• W1997334984 hasConcept C54009773 @default.
• W1997334984 hasConcept C542903549 @default.
• W1997334984 hasConcept C54355233 @default.
• W1997334984 hasConcept C70721500 @default.
• W1997334984 hasConcept C86803240 @default.
• W1997334984 hasConceptScore W1997334984C104317684 @default.
• W1997334984 hasConceptScore W1997334984C153911025 @default.
• W1997334984 hasConceptScore W1997334984C159047783 @default.
• W1997334984 hasConceptScore W1997334984C159654299 @default.
• W1997334984 hasConceptScore W1997334984C170493617 @default.
• W1997334984 hasConceptScore W1997334984C174510640 @default.

• next