FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997335051> ?p ?o ?g. }

• W1997335051 endingPage "328" @default.
• W1997335051 startingPage "317" @default.
• W1997335051 abstract "Over 30 years ago, ZTP (5-aminoimidazole-4-carboxamide riboside 5'-triphosphate), a modified purine biosynthetic intermediate, was proposed to signal 10-formyl-tetrahydrofolate (10f-THF) deficiency in bacteria. However, the mechanisms by which this putative alarmone or its precursor ZMP (5-aminoimidazole-4-carboxamide ribonucleotide, also known as AICAR) brings about any metabolic changes remain unexplained. Herein, we report the existence of a widespread riboswitch class that is most commonly associated with genes related to de novo purine biosynthesis and one-carbon metabolism. Biochemical data confirm that members of this riboswitch class selectively bind ZMP and ZTP with nanomolar affinity while strongly rejecting numerous natural analogs. Indeed, increases in the ZMP/ZTP pool, caused by folate stress in bacterial cells, trigger changes in the expression of a reporter gene fused to representative ZTP riboswitches in vivo. The wide distribution of this riboswitch class suggests that ZMP/ZTP signaling is important for species in numerous bacterial lineages." @default.
• W1997335051 created "2016-06-24" @default.
• W1997335051 creator A5032645821 @default.
• W1997335051 creator A5044106254 @default.
• W1997335051 creator A5058375820 @default.
• W1997335051 date "2015-01-01" @default.
• W1997335051 modified "2023-10-16" @default.
• W1997335051 title "An Ancient Riboswitch Class in Bacteria Regulates Purine Biosynthesis and One-Carbon Metabolism" @default.
• W1997335051 cites W1499922304 @default.
• W1997335051 cites W1518638519 @default.
• W1997335051 cites W1625866499 @default.
• W1997335051 cites W1896818705 @default.
• W1997335051 cites W1901656938 @default.
• W1997335051 cites W1964141703 @default.
• W1997335051 cites W1972139720 @default.
• W1997335051 cites W1975715632 @default.
• W1997335051 cites W1981066521 @default.
• W1997335051 cites W1987568156 @default.
• W1997335051 cites W1988145538 @default.
• W1997335051 cites W1994028292 @default.
• W1997335051 cites W2002583208 @default.
• W1997335051 cites W2006774276 @default.
• W1997335051 cites W2010587976 @default.
• W1997335051 cites W2014839221 @default.
• W1997335051 cites W2015787802 @default.
• W1997335051 cites W2018290536 @default.
• W1997335051 cites W2018738038 @default.
• W1997335051 cites W2019638327 @default.
• W1997335051 cites W2020983758 @default.
• W1997335051 cites W2030712030 @default.
• W1997335051 cites W2031318656 @default.
• W1997335051 cites W2032896907 @default.
• W1997335051 cites W2035234400 @default.
• W1997335051 cites W2041053455 @default.
• W1997335051 cites W2042366342 @default.
• W1997335051 cites W2043458609 @default.
• W1997335051 cites W2048706341 @default.
• W1997335051 cites W2050641111 @default.
• W1997335051 cites W2052214665 @default.
• W1997335051 cites W2057869907 @default.
• W1997335051 cites W2059833435 @default.
• W1997335051 cites W2061075485 @default.
• W1997335051 cites W2062955020 @default.
• W1997335051 cites W2067258168 @default.
• W1997335051 cites W2079911379 @default.
• W1997335051 cites W2084866368 @default.
• W1997335051 cites W2088267546 @default.
• W1997335051 cites W2100816704 @default.
• W1997335051 cites W2109189401 @default.
• W1997335051 cites W2120840862 @default.
• W1997335051 cites W2122282339 @default.
• W1997335051 cites W2122914162 @default.
• W1997335051 cites W2128912763 @default.
• W1997335051 cites W2129215648 @default.
• W1997335051 cites W2130097072 @default.
• W1997335051 cites W2131706188 @default.
• W1997335051 cites W2132920850 @default.
• W1997335051 cites W2139324374 @default.
• W1997335051 cites W2150714346 @default.
• W1997335051 cites W2153461732 @default.
• W1997335051 cites W2163813592 @default.
• W1997335051 cites W2166374078 @default.
• W1997335051 cites W2166747668 @default.
• W1997335051 cites W2168974900 @default.
• W1997335051 cites W2189088028 @default.
• W1997335051 cites W2209685769 @default.
• W1997335051 doi "https://doi.org/10.1016/j.molcel.2015.01.001" @default.
• W1997335051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4538711" @default.
• W1997335051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25616067" @default.
• W1997335051 hasPublicationYear "2015" @default.
• W1997335051 type Work @default.
• W1997335051 sameAs 1997335051 @default.
• W1997335051 citedByCount "95" @default.
• W1997335051 countsByYear W19973350512015 @default.
• W1997335051 countsByYear W19973350512016 @default.
• W1997335051 countsByYear W19973350512017 @default.
• W1997335051 countsByYear W19973350512018 @default.
• W1997335051 countsByYear W19973350512019 @default.
• W1997335051 countsByYear W19973350512020 @default.
• W1997335051 countsByYear W19973350512021 @default.
• W1997335051 countsByYear W19973350512022 @default.
• W1997335051 countsByYear W19973350512023 @default.
• W1997335051 crossrefType "journal-article" @default.
• W1997335051 hasAuthorship W1997335051A5032645821 @default.
• W1997335051 hasAuthorship W1997335051A5044106254 @default.
• W1997335051 hasAuthorship W1997335051A5058375820 @default.
• W1997335051 hasBestOaLocation W19973350511 @default.
• W1997335051 hasConcept C104317684 @default.
• W1997335051 hasConcept C148625055 @default.
• W1997335051 hasConcept C150194340 @default.
• W1997335051 hasConcept C161733203 @default.
• W1997335051 hasConcept C169586020 @default.
• W1997335051 hasConcept C181199279 @default.
• W1997335051 hasConcept C194993378 @default.
• W1997335051 hasConcept C2776328115 @default.
• W1997335051 hasConcept C2776476023 @default.
• W1997335051 hasConcept C523546767 @default.
• W1997335051 hasConcept C54355233 @default.

• next