Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997335097> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1997335097 endingPage "333" @default.
- W1997335097 startingPage "329" @default.
- W1997335097 abstract "1. This study was designed to investigate the antinociceptive activity of capsaicin in acute and persistent nocifensor behavioural models and to determine whether this was mediated via a specific receptor interaction, by use of the antagonist, capsazepine. 2. Capsaicin administered systemically in low doses produced antinociception in the knee joint hyperalgesia, rat paw pressure, rat and mouse tail flick and mouse hot plate nocifensor models with similar efficacy in all tests. 3. The novel competitive capsaicin antagonist, capsazepine, prevented the capsaicin-induced antinociception when administered systemically in the range 50-100 mumol kg-1. 4. Capsazepine administered by itself had no antinociceptive actions. 5. These data describe a joint hyperalgesic model in the rat which does not rely on extreme nocifensor behavioural endpoints and it is suggested this is a useful model for investigating mechanisms in persistent pain. 6. This is the first demonstration of antagonism by capsazepine of the behavioural antinociceptive properties of capsaicin and provides further evidence that capsaicin acts to reduce nociceptive thresholds via a specific receptor." @default.
- W1997335097 created "2016-06-24" @default.
- W1997335097 creator A5042138356 @default.
- W1997335097 creator A5043013940 @default.
- W1997335097 date "1992-10-01" @default.
- W1997335097 modified "2023-10-17" @default.
- W1997335097 title "Capsazepine reversal of the antinociceptive action of capsaicin in vivo" @default.
- W1997335097 cites W1573952482 @default.
- W1997335097 cites W1906123128 @default.
- W1997335097 cites W1973806783 @default.
- W1997335097 cites W1990519669 @default.
- W1997335097 cites W1990879069 @default.
- W1997335097 cites W2023347221 @default.
- W1997335097 cites W2048510761 @default.
- W1997335097 cites W2051786604 @default.
- W1997335097 cites W2057204344 @default.
- W1997335097 cites W2097141920 @default.
- W1997335097 cites W2119975102 @default.
- W1997335097 cites W2125441842 @default.
- W1997335097 cites W2153936909 @default.
- W1997335097 cites W2256167805 @default.
- W1997335097 doi "https://doi.org/10.1111/j.1476-5381.1992.tb12746.x" @default.
- W1997335097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1907885" @default.
- W1997335097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1422585" @default.
- W1997335097 hasPublicationYear "1992" @default.
- W1997335097 type Work @default.
- W1997335097 sameAs 1997335097 @default.
- W1997335097 citedByCount "93" @default.
- W1997335097 countsByYear W19973350972013 @default.
- W1997335097 countsByYear W19973350972014 @default.
- W1997335097 countsByYear W19973350972015 @default.
- W1997335097 countsByYear W19973350972016 @default.
- W1997335097 countsByYear W19973350972017 @default.
- W1997335097 countsByYear W19973350972020 @default.
- W1997335097 countsByYear W19973350972022 @default.
- W1997335097 crossrefType "journal-article" @default.
- W1997335097 hasAuthorship W1997335097A5042138356 @default.
- W1997335097 hasAuthorship W1997335097A5043013940 @default.
- W1997335097 hasBestOaLocation W19973350971 @default.
- W1997335097 hasConcept C15490471 @default.
- W1997335097 hasConcept C155164980 @default.
- W1997335097 hasConcept C160145004 @default.
- W1997335097 hasConcept C170493617 @default.
- W1997335097 hasConcept C185592680 @default.
- W1997335097 hasConcept C2776885963 @default.
- W1997335097 hasConcept C2777383412 @default.
- W1997335097 hasConcept C2777883359 @default.
- W1997335097 hasConcept C2779245659 @default.
- W1997335097 hasConcept C2780051329 @default.
- W1997335097 hasConcept C2780071552 @default.
- W1997335097 hasConcept C42219234 @default.
- W1997335097 hasConcept C55493867 @default.
- W1997335097 hasConcept C71924100 @default.
- W1997335097 hasConcept C86811712 @default.
- W1997335097 hasConcept C98274493 @default.
- W1997335097 hasConceptScore W1997335097C15490471 @default.
- W1997335097 hasConceptScore W1997335097C155164980 @default.
- W1997335097 hasConceptScore W1997335097C160145004 @default.
- W1997335097 hasConceptScore W1997335097C170493617 @default.
- W1997335097 hasConceptScore W1997335097C185592680 @default.
- W1997335097 hasConceptScore W1997335097C2776885963 @default.
- W1997335097 hasConceptScore W1997335097C2777383412 @default.
- W1997335097 hasConceptScore W1997335097C2777883359 @default.
- W1997335097 hasConceptScore W1997335097C2779245659 @default.
- W1997335097 hasConceptScore W1997335097C2780051329 @default.
- W1997335097 hasConceptScore W1997335097C2780071552 @default.
- W1997335097 hasConceptScore W1997335097C42219234 @default.
- W1997335097 hasConceptScore W1997335097C55493867 @default.
- W1997335097 hasConceptScore W1997335097C71924100 @default.
- W1997335097 hasConceptScore W1997335097C86811712 @default.
- W1997335097 hasConceptScore W1997335097C98274493 @default.
- W1997335097 hasIssue "2" @default.
- W1997335097 hasLocation W19973350971 @default.
- W1997335097 hasLocation W19973350972 @default.
- W1997335097 hasLocation W19973350973 @default.
- W1997335097 hasLocation W19973350974 @default.
- W1997335097 hasOpenAccess W1997335097 @default.
- W1997335097 hasPrimaryLocation W19973350971 @default.
- W1997335097 hasRelatedWork W1943223742 @default.
- W1997335097 hasRelatedWork W1986072332 @default.
- W1997335097 hasRelatedWork W2009326432 @default.
- W1997335097 hasRelatedWork W2038631083 @default.
- W1997335097 hasRelatedWork W2048812251 @default.
- W1997335097 hasRelatedWork W222299101 @default.
- W1997335097 hasRelatedWork W2258365099 @default.
- W1997335097 hasRelatedWork W2770517043 @default.
- W1997335097 hasRelatedWork W2928010947 @default.
- W1997335097 hasRelatedWork W2094055425 @default.
- W1997335097 hasVolume "107" @default.
- W1997335097 isParatext "false" @default.
- W1997335097 isRetracted "false" @default.
- W1997335097 magId "1997335097" @default.
- W1997335097 workType "article" @default.