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• W1997338093 endingPage "353" @default.
• W1997338093 startingPage "347" @default.
• W1997338093 abstract "Inactivation of mammalian telomerase leads to telomere attrition, eventually culminating in uncapped telomeres, which elicit a DNA damage response and cell cycle arrest or death. In some instances, telomerase modulation evokes a response not obviously attributable to changes in telomere length. One such example is the suppression of the DNA damage response (DDR) and changes in histone modification that occur upon repression of the telomerase reverse transcriptase, TERT, in human primary cells [K. Masutomi, R. Possemato, J.M. Wong, J.L. Currier, Z. Tothova, J.B. Manola, S. Ganesan, P.M. Lansdorp, K. Collins and W.C. Hahn, The telomerase reverse transcriptase regulates chromatin state and DNA damage responses, Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 8222–8227]. Here, we evaluate the contribution of TERT to the DDR in murine Tert−/− cells without critically shortened telomeres. We treated mTert−/− embryonic stem (ES) cells and murine embryonic fibroblasts (MEFs) with etoposide and irradiation, and assessed the status of p53pS15, 53BP1, ATMpS1981, SMC1pS957, and γH2AX by indirect immunofluorescence or western blotting. In four independently derived mTert−/− ES cell lines, there was no significant difference in the induction of γH2AX, 53BP1 foci, or the phosphorylation of ATM targets (ATM, SMC1, p53) between wildtype and mTert−/− ES cells and MEFs. A slight difference in post-translational modification of histones H3 and H4 was observed in a subset of mTert−/− ES cells, however this difference was reflected in the cellular levels of H3 and H4. Thus, in contrast to previous studies in human cells, the absence of Tert does not overtly affect the ATM-dependent response to DNA damage in murine cells." @default.
• W1997338093 created "2016-06-24" @default.
• W1997338093 creator A5022172673 @default.
• W1997338093 creator A5032127149 @default.
• W1997338093 date "2009-03-01" @default.
• W1997338093 modified "2023-10-16" @default.
• W1997338093 title "No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells" @default.
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• W1997338093 cites W1861951729 @default.
• W1997338093 cites W1927581912 @default.
• W1997338093 cites W1965035358 @default.
• W1997338093 cites W1967587710 @default.
• W1997338093 cites W1970891016 @default.
• W1997338093 cites W1972655555 @default.
• W1997338093 cites W1973544851 @default.
• W1997338093 cites W1973552223 @default.
• W1997338093 cites W1982199027 @default.
• W1997338093 cites W1983298684 @default.
• W1997338093 cites W1984280207 @default.
• W1997338093 cites W1985641439 @default.
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• W1997338093 cites W1988168493 @default.
• W1997338093 cites W1989736755 @default.
• W1997338093 cites W1993152080 @default.
• W1997338093 cites W1995480256 @default.
• W1997338093 cites W1998335196 @default.
• W1997338093 cites W1998901490 @default.
• W1997338093 cites W2005029311 @default.
• W1997338093 cites W2017752436 @default.
• W1997338093 cites W2020717634 @default.
• W1997338093 cites W2024068850 @default.
• W1997338093 cites W2024153222 @default.
• W1997338093 cites W2027931017 @default.
• W1997338093 cites W2028044172 @default.
• W1997338093 cites W2030071293 @default.
• W1997338093 cites W2032694449 @default.
• W1997338093 cites W2037236933 @default.
• W1997338093 cites W2043204829 @default.
• W1997338093 cites W2044758458 @default.
• W1997338093 cites W2045438816 @default.
• W1997338093 cites W2050166933 @default.
• W1997338093 cites W2052066518 @default.
• W1997338093 cites W2052118210 @default.
• W1997338093 cites W2054293223 @default.
• W1997338093 cites W2058108472 @default.
• W1997338093 cites W2061900171 @default.
• W1997338093 cites W2063423712 @default.
• W1997338093 cites W2065841924 @default.
• W1997338093 cites W2071746963 @default.
• W1997338093 cites W2072727556 @default.
• W1997338093 cites W2073658080 @default.
• W1997338093 cites W2075084906 @default.
• W1997338093 cites W2075679034 @default.
• W1997338093 cites W2084017895 @default.
• W1997338093 cites W2085418826 @default.
• W1997338093 cites W2085786821 @default.
• W1997338093 cites W2086089050 @default.
• W1997338093 cites W2086545698 @default.
• W1997338093 cites W2087095797 @default.
• W1997338093 cites W2106311785 @default.
• W1997338093 cites W2109254920 @default.
• W1997338093 cites W2109768043 @default.
• W1997338093 cites W2115936666 @default.
• W1997338093 cites W2116212264 @default.
• W1997338093 cites W2119463579 @default.
• W1997338093 cites W2126004462 @default.
• W1997338093 cites W2126815966 @default.
• W1997338093 cites W2130141211 @default.
• W1997338093 cites W2132462187 @default.
• W1997338093 cites W2135612520 @default.
• W1997338093 cites W2136986586 @default.
• W1997338093 cites W2140895326 @default.
• W1997338093 cites W2141157651 @default.
• W1997338093 cites W2141723290 @default.
• W1997338093 cites W2144794152 @default.
• W1997338093 cites W2147319330 @default.
• W1997338093 cites W2148531499 @default.
• W1997338093 cites W2149045518 @default.
• W1997338093 cites W2149129068 @default.
• W1997338093 cites W2154837214 @default.
• W1997338093 cites W2156127375 @default.
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• W1997338093 doi "https://doi.org/10.1016/j.dnarep.2008.11.009" @default.
• W1997338093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2663532" @default.
• W1997338093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19071232" @default.
• W1997338093 hasPublicationYear "2009" @default.
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