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- W1997341912 abstract "Prolonged administration of hydrochlorothiazide (HCT) depresses norepinephrine vasoconstriction. In an attempt to explain these findings, the effect of HCT on calcium kinetics in the vessels was investigated in the present study. Mesenteric veins of rabbits treated with HCT for 6–10 weeks took up considerably more 45 Ca in vitro (p < 0.01) than veins of control animals. The efflux of 45 Ca was similar in treated and control animals. Residual radioactivity was almost three times as high in vessels of HCT-treated rabbits. After a 4 week long administration of HCT, Ca kinetics were not yet altered, indicating the importance of the time element in the action of the drug. As a working hypothesis we suggest that prolonged treatment with HCT causes trapping of Ca in an intracellular compartment of vascular smooth muscle, making it less available for norepinephrine vasoconstriction." @default.
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- W1997341912 date "1973-08-01" @default.
- W1997341912 modified "2023-09-26" @default.
- W1997341912 title "Effect of Hydrochlorothiazide on Calcium Kinetics in Blood Vessels" @default.
- W1997341912 doi "https://doi.org/10.1139/y73-087" @default.
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