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- W1997350057 abstract "A selective and sensitive method is presented for the determination of L-iminoethyl-L-lysine (L-NIL) in rat serum. L-NIL is a selective inhibitor of the inducible nitric oxide synthase. The analytical technique is based upon a two-buffer reversed-phase HPLC system with fluorescence detection of pre-column derivatized amino acid analogue with o-phtaldialdehyde. The retention time of L-NIL was 19.4 min. The limit of quantification was 0.5 mg/l. After validation, the method was used to study the pharmacokinetic profile of L-NIL in rats after intravenous as well as oral administration of a single dose." @default.
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- W1997350057 date "2000-11-01" @default.
- W1997350057 modified "2023-09-27" @default.
- W1997350057 title "Determination of l-iminoethyl-l-lysine in serum by liquid chromatography" @default.
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- W1997350057 doi "https://doi.org/10.1016/s0378-4347(00)00375-3" @default.
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