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- W1997351792 abstract "Radioactive 2-OHE1 2-Me∗ and 4-OHE1 4-Me was orally administered to one healthy male subject. The total radioactivity excreted within 5 days was 80 and 90%, respectively. About 0.5% and 2.7% of the urinary radioactivity consisted of free steroids. They were identified as 2-OHE1 (0.2%) and 2-OHE2, (0.1%) and 4-OHE1 (0.8%) and 4-OHE2 (0.7%), respectively. The remaining conjugate fraction consisted of steroid-sulphates and steroid-glucuronides. The steroid moieties, released by acid-hydrolysis, were identified as 2-OHE1 (27.9%), 2-OHE2 (3.4%), 2-OHE1 2-Me (25.2%), 2-OHE1 3-Me (1.2%), 2-OHE2 2-Me (2.8%) and 2-OHE3 2-Me (0.3%) and 4-OHE1 (13.6%), 4-OHE2 (4.2%), 4-OHE1 4-Me (43.0%) and 4-OHE2 4-Me (4.0%), respectively. Ring-A polyhydroxylated compounds were not detected in the urine." @default.
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- W1997351792 date "1977-09-01" @default.
- W1997351792 modified "2023-10-16" @default.
- W1997351792 title "Metabolism of 2-methoxy- and 4-methoxyoestrone in man in vivo" @default.
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- W1997351792 doi "https://doi.org/10.1016/0022-4731(77)90198-4" @default.
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