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• W1997354002 abstract "No AccessJournal of UrologyAdult urology1 Oct 2007Uroplakin III-Delta4 Messenger RNA as a Promising Marker to Identify Nonulcerative Interstitial Cystitisis accompanied byEnhanced Adenosine Triphosphate Release From the Urothelium of Patients With Painful Bladder Syndrome: A Possible Pathophysiological Explanation Yu Zeng, Xiu-Xian Wu, Yukio Homma, Naoki Yoshimura, Hideaki Iwaki, Susumu Kageyama, Tatsuhiro Yoshiki, and Yoshiyuki Kakehi Yu ZengYu Zeng Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan More articles by this author , Xiu-Xian WuXiu-Xian Wu Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan More articles by this author , Yukio HommaYukio Homma Japanese Red Cross Medical Center, Tokyo, Japan Financial interest and/or other relationship with Pfizer, Astellas and Taiho. More articles by this author , Naoki YoshimuraNaoki Yoshimura University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania More articles by this author , Hideaki IwakiHideaki Iwaki Shiga Medical University, Seta, Japan More articles by this author , Susumu KageyamaSusumu Kageyama Shiga Medical University, Seta, Japan More articles by this author , Tatsuhiro YoshikiTatsuhiro Yoshiki Shiga Medical University, Seta, Japan More articles by this author , and Yoshiyuki KakehiYoshiyuki Kakehi Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.05.125AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Interstitial cystitis remains a poorly understood urological condition characterized by chronic pelvic pain and increased urinary frequency in the absence of any known etiology. Urothelial dysfunction and other abnormalities are presumed to be involved in the disease. Uroplakins that are expressed by urothelial cells are thought to have an important role as major barrier proteins on the apical surface of the urothelium. Materials and Methods: Gene expression of uroplakin Ia, Ib, II, III and III-delta4 was quantitatively measured in bladder biopsy samples from 29 patients with interstitial cystitis and 16 control subjects using real-time reverse transcriptase-polymerase chain reaction. Results: The mRNA levels of the uroplakin Ia, Ib and II genes were relatively low and uroplakin III was relatively high in interstitial cystitis bladders compared to normal controls, although not significantly. Uroplakin III-delta4, a splicing variant of uroplakin III, was significantly up-regulated in interstitial cystitis samples (p <0.001). When patients with interstitial cystitis were divided into those with and without ulcerative changes, the uroplakin III and III-delta4 genes were significantly up-regulated only in patients with nonulcerative interstitial cystitis. Even more interesting was the finding that up-regulation of uroplakin III-delta4 was much more prominent than that of uroplakin III, that is 26.5 vs 5.6-fold compared to the median values of normal subjects. Conclusions: Although the clinical implications of the over expression of uroplakin III and III-delta4 in nonulcerative interstitial cystitis bladders remains to be clarified, from the diagnostic viewpoint uroplakin III-delta4 is a potential marker for identifying nonulcerative interstitial cystitis. References 1 : Prevalence and incidence of interstitial cystitis in a managed care population. J Urol2005; 173: 98. Link, Google Scholar 2 : Clinical features and spectrum of light microscopic changes in interstitial cystitis. J Urol1990; 143: 1118. 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Google Scholar © 2007 by American Urological AssociationFiguresReferencesRelatedDetailsCited byHomma Y, Nomiya A, Tagaya M, Oyama T, Takagaki K, Nishimatsu H and Igawa Y (2013) Increased mRNA Expression of Genes Involved in Pronociceptive Inflammatory Reactions in Bladder Tissue of Interstitial CystitisJournal of Urology, VOL. 190, NO. 5, (1925-1931), Online publication date: 1-Nov-2013.Blalock E, Korrect G, Stromberg A and Erickson D (2011) Gene Expression Analysis of Urine Sediment: Evaluation for Potential Noninvasive Markers of Interstitial Cystitis/Bladder Pain SyndromeJournal of Urology, VOL. 187, NO. 2, (725-732), Online publication date: 1-Feb-2012.Ogawa T, Homma T, Igawa Y, Seki S, Ishizuka O, Imamura T, Akahane S, Homma Y and Nishizawa O (2010) CXCR3 Binding Chemokine and TNFSF14 Over Expression in Bladder Urothelium of Patients With Ulcerative Interstitial CystitisJournal of Urology, VOL. 183, NO. 3, (1206-1212), Online publication date: 1-Mar-2010.Erickson D, Schwarze S, Dixon J, Clark C and Hersh M (2008) Differentiation Associated Changes in Gene Expression Profiles of Interstitial Cystitis and Control Urothelial CellsJournal of Urology, VOL. 180, NO. 6, (2681-2687), Online publication date: 1-Dec-2008.Erickson D, Tomaszewski J, Kunselman A, Stetter C, Peters K, Rovner E, Demers L, Wheeler M and Keay S (2008) Urine Markers Do Not Predict Biopsy Findings or Presence of Bladder Ulcers in Interstitial Cystitis/Painful Bladder SyndromeJournal of Urology, VOL. 179, NO. 5, (1850-1856), Online publication date: 1-May-2008.Related articlesJournal of Urology16 Aug 2007Enhanced Adenosine Triphosphate Release From the Urothelium of Patients With Painful Bladder Syndrome: A Possible Pathophysiological Explanation Volume 178Issue 4October 2007Page: 1322-1327 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordsalternative splicingulcerbladderuroplakin IIIcystitis, interstitialAcknowledgmentsDrs. Katsumi Imaida and Masanao Yokohira, Onco-Pathology, Department of Pathology and Host-Defense, and Dr. Bin Wu, Department of Inflammation Pathology, Kagawa University Faculty of Medicine assisted with immunohistochemical staining analysis.MetricsAuthor Information Yu Zeng Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan More articles by this author Xiu-Xian Wu Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan More articles by this author Yukio Homma Japanese Red Cross Medical Center, Tokyo, Japan Financial interest and/or other relationship with Pfizer, Astellas and Taiho. More articles by this author Naoki Yoshimura University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania More articles by this author Hideaki Iwaki Shiga Medical University, Seta, Japan More articles by this author Susumu Kageyama Shiga Medical University, Seta, Japan More articles by this author Tatsuhiro Yoshiki Shiga Medical University, Seta, Japan More articles by this author Yoshiyuki Kakehi Department of Urology, Kagawa University Faculty of Medicine, Kagawa, Japan More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W1997354002 title "Uroplakin III-Delta4 Messenger RNA as a Promising Marker to Identify Nonulcerative Interstitial Cystitis" @default.
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