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• W199735443 abstract "7 Introduction 9 Review of the literature 10 1. History of CML 10 2. Clinical characteristics of CML 12 2.1. Epidemiology 13 2.2. Clinical course of CML 13 2.3. Risk scores 14 2.4. Immunological background of CML 15 3. The cytogenetics of CML 16 3.1. Standard Ph translocation 16 3.2. Variant Ph translocations 16 3.3. Ph negative, BCR-ABL fusion positive CML 17 3.4. Deletions of the derivative chromosome 9 18 3.4.1. When are der(9) deletions formed? 20 3.4.2. The clinical impact of der(9) deletions 20 3.5. Clonal evolution 20 3.6. Clonal chromosomal changes in Ph negative cells 21 3.7. Ph chromosome in other hematological malignancies 22 4. Molecular genetics and pathology of CML 22 4.1. Oncogenic tyrosine kinases in hematological malignancies 22 4.2. Abelson murine leukemia viral oncogene homolog 1 (ABL) gene 22 4.3. Breakpoint cluster region (BCR) gene 24 4.4. The BCR-ABL fusion gene 24 4.5. Cellular signaling pathways affected by BCR-ABL 26 5. The role of genetic analyses in diagnostics and follow-up of CML 27 5.1. Analyses performed at the diagnostic phase 27 5.2. Follow-up studies and minimal residual disease analyses 27 5.2.1. Cytogenetic follow-up analyses 27 5.2.2. Molecular genetic follow-up studies 28 5.2.3. International standardization of RQ-PCR assays in minimal residual disease analytics........ 29 6. Treatment of CML 30 6.1. Imatinib: the current gold standard of CML treatment 30 6.1.1. The mechanism of imatinib kinase inhibition 31 6.1.2. The IRIS (International Randomized Study of Interferon and STI571) trial 32 6.2. Allogeneic hematopoietic stem cell transplantation (alloHSCT) 33 7. Imatinib resistance 33 7.1. BCR-ABL gene amplification 34 7.2. Mutations in the kinase domain of BCR-ABL 35 7.3. BCR-ABL independent resistance mechanisms 37 8. Second generation tyrosine kinase inhibitors 39 8.1. Dasatinib 39 8.2. Nilotinib 39 8.3. Other second generation tyrosine kinase inhibitors 40 8.4. Resistance against second generation tyrosine kinase inhibitors 40" @default.
• W199735443 created "2016-06-24" @default.
• W199735443 creator A5051537989 @default.
• W199735443 date "2008-06-06" @default.
• W199735443 modified "2023-09-24" @default.
• W199735443 title "Novel prognostic factors in chronic myeloid leukemia" @default.
• W199735443 cites W114795016 @default.
• W199735443 cites W120419820 @default.
• W199735443 cites W120676909 @default.
• W199735443 cites W126560450 @default.
• W199735443 cites W1421162947 @default.
• W199735443 cites W1430390330 @default.
• W199735443 cites W1484834653 @default.
• W199735443 cites W1490418776 @default.
• W199735443 cites W1498187417 @default.
• W199735443 cites W1510546584 @default.
• W199735443 cites W1525233566 @default.
• W199735443 cites W1534536204 @default.
• W199735443 cites W1559908984 @default.
• W199735443 cites W1573399247 @default.
• W199735443 cites W157985536 @default.
• W199735443 cites W1587979812 @default.
• W199735443 cites W1590827448 @default.
• W199735443 cites W1600808238 @default.
• W199735443 cites W1617405356 @default.
• W199735443 cites W1639582946 @default.
• W199735443 cites W1679250118 @default.
• W199735443 cites W1719330231 @default.
• W199735443 cites W1799579309 @default.
• W199735443 cites W186063976 @default.
• W199735443 cites W190106789 @default.
• W199735443 cites W190597540 @default.
• W199735443 cites W1929127637 @default.
• W199735443 cites W1931995632 @default.
• W199735443 cites W1955569686 @default.
• W199735443 cites W1964445294 @default.
• W199735443 cites W1965476381 @default.
• W199735443 cites W1965527326 @default.
• W199735443 cites W1967920366 @default.
• W199735443 cites W1968022845 @default.
• W199735443 cites W1968071128 @default.
• W199735443 cites W1968351802 @default.
• W199735443 cites W1968572823 @default.
• W199735443 cites W1968640966 @default.
• W199735443 cites W1968944733 @default.
• W199735443 cites W1970012935 @default.
• W199735443 cites W1970154345 @default.
• W199735443 cites W1970962471 @default.
• W199735443 cites W1971331718 @default.
• W199735443 cites W1973085375 @default.
• W199735443 cites W1973720500 @default.
• W199735443 cites W1973942694 @default.
• W199735443 cites W1975595356 @default.
• W199735443 cites W1975748957 @default.
• W199735443 cites W1976023782 @default.
• W199735443 cites W1979107490 @default.
• W199735443 cites W1979697113 @default.
• W199735443 cites W1979799620 @default.
• W199735443 cites W1982687598 @default.
• W199735443 cites W1983618173 @default.
• W199735443 cites W1983860551 @default.
• W199735443 cites W1984160018 @default.
• W199735443 cites W1984898282 @default.
• W199735443 cites W1985318073 @default.
• W199735443 cites W1985863699 @default.
• W199735443 cites W1987124048 @default.
• W199735443 cites W1987239635 @default.
• W199735443 cites W1988399039 @default.
• W199735443 cites W1988464631 @default.
• W199735443 cites W1988586881 @default.
• W199735443 cites W1988750150 @default.
• W199735443 cites W1989648826 @default.
• W199735443 cites W1989860697 @default.
• W199735443 cites W1991273254 @default.
• W199735443 cites W1991387267 @default.
• W199735443 cites W1991859383 @default.
• W199735443 cites W1992244448 @default.
• W199735443 cites W1993730967 @default.
• W199735443 cites W1993887562 @default.
• W199735443 cites W1994294560 @default.
• W199735443 cites W1994309500 @default.
• W199735443 cites W1994457998 @default.
• W199735443 cites W1997360163 @default.
• W199735443 cites W1997432620 @default.
• W199735443 cites W1998593414 @default.
• W199735443 cites W1998812470 @default.
• W199735443 cites W1999277101 @default.
• W199735443 cites W1999614615 @default.
• W199735443 cites W1999644963 @default.
• W199735443 cites W2000991239 @default.
• W199735443 cites W2001313342 @default.
• W199735443 cites W2002473554 @default.
• W199735443 cites W2003596377 @default.
• W199735443 cites W2003973314 @default.
• W199735443 cites W2004492241 @default.
• W199735443 cites W2006467763 @default.
• W199735443 cites W2006518962 @default.
• W199735443 cites W2006917576 @default.
• W199735443 cites W2007227525 @default.
• W199735443 cites W2008649212 @default.

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