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• W1997354888 abstract "Abstract The aim of this research was to study the changes of the motor reflex activity (monosynaptic reflex (MSR) of the flexor and extensor muscles) and Fos immunoreactivity in lumbo‐sacral spinal cord after acute induced myositis of m. gastrocnemius‐soleus (GS). The experiments were carried out on ischaemic decerebrated, spinalized in C1 cats. After infiltration of the GS muscle with carrageenan (2%) MSRs of flexors and extensors showed a significant increase in amplitude +127±24.5% and +155±28.5%, respectively, p <0.05. The exposed effect was initiated within 30min and achieved a maximum 2.8h after the intramuscular injections of carrageenan. After analysis of dynamics of the MSRs, animals were perfused and c‐fos expression in the spinal segments L6–S1 was evaluated. In comparison to sham‐operated animals, the number of Fos‐immunoreactive (Fos‐ir) cells was noticeably increased in the lumbar cord of cats with carrageenan‐induced myositis. The labeled cells were concentrated in the ipsilateral laminae I/II, neck of the dorsal horn (V/VI) and intermediate zone (VII), however, clear predominance of their concentration was found in the deep laminae. The effect of muscle inflammation was also expressed as a significant decline in the number of NADPH‐d‐reactive cells ( p <0.05) in ipsilateral laminae I/II of L6/L7. The results show that the input from acutely inflamed muscles may induce an increase of the reflex responsiveness of flexors and extensors which is not mediated via the gamma‐spindle‐loop and which coincides with a significant increase in c‐fos expression in the deep laminae of the lumbar spinal cord." @default.
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• W1997354888 date "2007-07-01" @default.
• W1997354888 modified "2023-10-18" @default.
• W1997354888 title "Acute muscle inflammation enhances the monosynaptic reflexes and c-fos expression in the feline spinal cord" @default.
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• W1997354888 doi "https://doi.org/10.1016/j.ejpain.2006.09.004" @default.
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