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- W1997360636 abstract "Monkey infection models are absolutely necessary for studies of human immunodeficiency virus type 1 (HIV-1) pathogenesis and of developing drugs/vaccines against HIV-1. In addition, currently unknown roles of its accessory proteins for in vivo replication await elucidation by experimental approaches. Due to the fact that HIV-1 is tropic only for chimpanzees and humans, studies of this line have been impeded for a long time, although various investigations have been carried out utilising genetically related SIV and SIV/HIV chimeric virus (SHIV) as pathogens. Recent findings of anti-HIV-1 innate factors such as tripartite motif protein 5alpha (TRIM5alpha) and APOBEC3G/F prompted us to re-initiate an old and vital research project which would, as a result, confer the capability to overcome the species barrier on the HIV-1. We currently have obtained, by virus engineering through genetic manipulation and adaptation, some new and promising HIV-1 clones for in vivo studies in macaque monkeys as mentioned above. In this review, we summarise the past, present and future of HIV-1/SIV chimeric viruses with special reference to relevant basic HIV-1/SIV studies." @default.
- W1997360636 created "2016-06-24" @default.
- W1997360636 creator A5013878003 @default.
- W1997360636 creator A5015956328 @default.
- W1997360636 creator A5046470452 @default.
- W1997360636 creator A5062630998 @default.
- W1997360636 date "2008-07-01" @default.
- W1997360636 modified "2023-10-14" @default.
- W1997360636 title "Species barrier of HIV‐1 and its jumping by virus engineering" @default.
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