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• W1997364010 startingPage "165" @default.
• W1997364010 abstract "Genetic variants at multiple loci have been shown to be associated with periodontitis risk. In this study, we have focused on nine functional gene polymorphisms encoding immunoregulation-related molecules such as cytokines (interleukin-1 (IL-1), transforming growth factor-β1 (TGF-β1)) and cell surface receptors (immunoglobulin G and A Fc receptors (FcγR and FcαR)). In total, 113 Japanese patients with chronic periodontitis (CP) and 108 race-matched healthy controls were genotyped with the modified serial invasive signal amplification reaction. There was a significant difference in the distribution of IL-1 receptor antagonist (RN) +2018 T/C allele between the patient and control groups, with enrichment of the +2018 C in controls (P = 0.021, odds ratio = 0.38). An increased frequency of the IL-1 haplotype comprising IL-1A +4845 G, IL-1B –31 C, and IL-1RN +2018 C was observed in controls (P = 0.004). Moreover, a multivariate logistic regression analysis revealed that subjects with IL-1RN +2018 C allele were less likely to have CP (P = 0.016, odds ratio = 0.29). These findings document the association of IL-1RN +2018 C with reduced susceptibility to CP in the Japanese." @default.
• W1997364010 created "2016-06-24" @default.
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• W1997364010 date "2008-04-01" @default.
• W1997364010 modified "2023-09-25" @default.
• W1997364010 title "Association of interleukin-1 receptor antagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method" @default.
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• W1997364010 doi "https://doi.org/10.1111/j.1744-313x.2008.00757.x" @default.
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