FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997365308> ?p ?o ?g. }

• W1997365308 endingPage "1064" @default.
• W1997365308 startingPage "1054" @default.
• W1997365308 abstract "Interleukin-6 (IL6) and vascular endothelial growth factor (VEGFA) are abundantly produced by glioma cells and contribute to malignancy by promoting angiogenesis, cell proliferation and resistance to apoptosis. We compared the effect of inhibiting IL6 and VEGF on U87-derived experimental glioma grown on the chick chorio-allantoic membrane (CAM) or in the brain of xenografted mice. Tumor growth was monitored by biomicroscopy and immunohistology. In vitro, IL6 knockdown had no effect on proliferation but substantially enhanced invasion. In the CAM experimental glioma, IL6 or VEGF knockdown reduced growth and vascularization of the tumors with a comparable efficiency, but increased invasion of residual tumor cells. In contrast, combined IL6/VEGF knockdown not only showed enhanced reduction of tumor growth and angiogenesis but also significantly prevented invasion of residual tumor cells. In mice, combining IL6 knockdown and Avastin™ treatment completely abrogated tumor development and infiltration. Molecular response of tumor cells to single or combined treatment was studied by transcriptomic profiling. Many cell cycle promoting genes and chromatin components were silenced in the double knockdown. In addition, specific migratory signatures detected in tumors under single IL6 or VEGF knockdown were partially erased in combined IL6/VEGF knockdown tumors. Our results show that treatment with a combination of IL6 and VEGF inhibitors brings synergistic antitumoral benefit and reduces global activity of major pathways of cell survival, proliferation and invasiveness in remaining tumor cells that may be induced by using VEGF or IL6 inhibitors alone. © 2009 UICC" @default.
• W1997365308 created "2016-06-24" @default.
• W1997365308 creator A5001695628 @default.
• W1997365308 creator A5005236926 @default.
• W1997365308 creator A5053354480 @default.
• W1997365308 creator A5054989793 @default.
• W1997365308 creator A5065216530 @default.
• W1997365308 creator A5071776802 @default.
• W1997365308 creator A5084124153 @default.
• W1997365308 creator A5087194857 @default.
• W1997365308 date "2009-02-23" @default.
• W1997365308 modified "2023-10-16" @default.
• W1997365308 title "Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness" @default.
• W1997365308 cites W1210551670 @default.
• W1997365308 cites W133015373 @default.
• W1997365308 cites W1652153701 @default.
• W1997365308 cites W1676928377 @default.
• W1997365308 cites W1857434043 @default.
• W1997365308 cites W1914292641 @default.
• W1997365308 cites W1950498857 @default.
• W1997365308 cites W1966222774 @default.
• W1997365308 cites W1974300394 @default.
• W1997365308 cites W1974356658 @default.
• W1997365308 cites W1977475244 @default.
• W1997365308 cites W1977999028 @default.
• W1997365308 cites W1981414879 @default.
• W1997365308 cites W1983939718 @default.
• W1997365308 cites W1983993814 @default.
• W1997365308 cites W1992912767 @default.
• W1997365308 cites W1999260149 @default.
• W1997365308 cites W2009671993 @default.
• W1997365308 cites W2012797123 @default.
• W1997365308 cites W2018016372 @default.
• W1997365308 cites W2028978262 @default.
• W1997365308 cites W2029079922 @default.
• W1997365308 cites W2031098493 @default.
• W1997365308 cites W2044056830 @default.
• W1997365308 cites W2044237057 @default.
• W1997365308 cites W2052432571 @default.
• W1997365308 cites W2053352199 @default.
• W1997365308 cites W2057811067 @default.
• W1997365308 cites W2058174575 @default.
• W1997365308 cites W2058426917 @default.
• W1997365308 cites W2060722835 @default.
• W1997365308 cites W2068797588 @default.
• W1997365308 cites W2072034493 @default.
• W1997365308 cites W2074198216 @default.
• W1997365308 cites W2074665594 @default.
• W1997365308 cites W2085227881 @default.
• W1997365308 cites W2087861230 @default.
• W1997365308 cites W2091977407 @default.
• W1997365308 cites W2092409918 @default.
• W1997365308 cites W2093783077 @default.
• W1997365308 cites W2099805317 @default.
• W1997365308 cites W2102891320 @default.
• W1997365308 cites W2106537986 @default.
• W1997365308 cites W2109134893 @default.
• W1997365308 cites W2114817620 @default.
• W1997365308 cites W2114998237 @default.
• W1997365308 cites W2130819084 @default.
• W1997365308 cites W2138872698 @default.
• W1997365308 cites W2141016223 @default.
• W1997365308 cites W2144114922 @default.
• W1997365308 cites W2145167850 @default.
• W1997365308 cites W2147535764 @default.
• W1997365308 cites W2148576723 @default.
• W1997365308 cites W2153787061 @default.
• W1997365308 cites W4246980730 @default.
• W1997365308 doi "https://doi.org/10.1002/ijc.24380" @default.
• W1997365308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19431143" @default.
• W1997365308 hasPublicationYear "2009" @default.
• W1997365308 type Work @default.
• W1997365308 sameAs 1997365308 @default.
• W1997365308 citedByCount "87" @default.
• W1997365308 countsByYear W19973653082012 @default.
• W1997365308 countsByYear W19973653082013 @default.
• W1997365308 countsByYear W19973653082014 @default.
• W1997365308 countsByYear W19973653082015 @default.
• W1997365308 countsByYear W19973653082016 @default.
• W1997365308 countsByYear W19973653082017 @default.
• W1997365308 countsByYear W19973653082018 @default.
• W1997365308 countsByYear W19973653082019 @default.
• W1997365308 countsByYear W19973653082020 @default.
• W1997365308 countsByYear W19973653082021 @default.
• W1997365308 countsByYear W19973653082022 @default.
• W1997365308 countsByYear W19973653082023 @default.
• W1997365308 crossrefType "journal-article" @default.
• W1997365308 hasAuthorship W1997365308A5001695628 @default.
• W1997365308 hasAuthorship W1997365308A5005236926 @default.
• W1997365308 hasAuthorship W1997365308A5053354480 @default.
• W1997365308 hasAuthorship W1997365308A5054989793 @default.
• W1997365308 hasAuthorship W1997365308A5065216530 @default.
• W1997365308 hasAuthorship W1997365308A5071776802 @default.
• W1997365308 hasAuthorship W1997365308A5084124153 @default.
• W1997365308 hasAuthorship W1997365308A5087194857 @default.
• W1997365308 hasBestOaLocation W19973653081 @default.
• W1997365308 hasConcept C146285616 @default.
• W1997365308 hasConcept C167734588 @default.

• next