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• W1997366178 abstract "The wide array of vital functions that RNA performs is dependent on its ability to dynamically fold into different structures in response to intracellular and extracellular changes. RNA-binding proteins regulate much of this activity by targeting specific RNA structures or motifs. One of these structures, the 3-way RNA junction, is characteristically found in ribosomal RNA and results from the RNA folding in cis, to produce three separate helices that meet around a central unpaired region. Here we demonstrate that 3-way junctions can also form in trans as a result of the binding of microRNAs in an unconventional manner with mRNA by splinting two non-contiguous regions together. This may be used to reinforce the base of a stem-loop motif being targeted by an RNA-binding protein. Trans interactions between non-coding RNA and mRNA may be used to control the post-transcriptional regulatory code and suggests a possible role for some of the recently described transcripts of unknown function expressed from the human genome." @default.
• W1997366178 created "2016-06-24" @default.
• W1997366178 creator A5024924406 @default.
• W1997366178 creator A5067368498 @default.
• W1997366178 date "2014-04-15" @default.
• W1997366178 modified "2023-10-12" @default.
• W1997366178 title "Trans-regulation of RNA-binding protein motifs by microRNA" @default.
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• W1997366178 doi "https://doi.org/10.3389/fgene.2014.00079" @default.
• W1997366178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4006066" @default.
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