FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997366308> ?p ?o ?g. }

• W1997366308 endingPage "48" @default.
• W1997366308 startingPage "29" @default.
• W1997366308 abstract "Previous results have indicated the involvement of the hippocampus in the behavioral effect of vasopressin, with a better effect when the peptide was injected in the ventral part rather than in the dorsal part of this structure. The purpose of the present study was to determine, in mice, whether the injection of vasopressin or vasopressin antisera into the ventral hippocampus has an effect on retrieval and relearning of a Go-No Go visual discrimination task and, if so, to what extent this involvement of the vasopressin system depends on the integrity of the medial amygdaloid nucleus, the main source of vasopressin innervation in the ventral hippocampus in rats. In the first experiment, we showed that pretest microinjection of Arg8-vasopressin (25 pg per animal) in the ventral hippocampus alleviated forgetting observed after a prolonged interval of 24 days between the acquisition of information and its retrieval. This enhancing effect was characterized by better retrieval and relearning in vasopressin-treated mice than those in control mice. Conversely, an immunoneutralization of endogenous vasopressin in the ventral hippocampus by the microinjection of vasopressin antisera (1/10 dilution) resulted in the drastic impairment of retrieval and relearning. Since the lack of an observable change in a locomotor activity test might explain these results, we postulated that the vasopressin system in the ventral hippocampus is involved in retrieval processes. Moreover, the effects of these treatments in a nonassociative context suggest that the effect of vasopressin could be dependent on the contextual paradigm used. In the second experiment, we localized vasopressin immunoreactive fibers in the CA1-CA2 ventral hippocampal fields and CA4-gyrus dentatus region, and vasopressin perikarya in the medial amygdaloid nucleus. Then, the projection of vasopressin cells from the medial amygdaloid nucleus to the ventral hippocampus was evaluated by studying changes in vasopressin immunoreactive fiber density in the ventral hippocampus after a lesion of the medial amygdaloid nucleus. The results showed the almost complete disappearance of vasopressin fibers in the CA1-CA2 hippocampal fields after the medial amygdaloid lesion. In contrast, vasopressin fibers in the CA4 and gyrus dentatus region remain unchanged. On the basis of our immunohistochemical results, our third experiment tested the repercussions of the change in vasopressin innervation in the ventral hippocampus, due to the medial amygdaloid lesion, on the effects of exogenously administered vasopressin on both retrieval and relearning processes. The medial amygdaloid lesion induced a deleterious effect on retrieval without really affecting the ability to relearn. No observable change in locomotor activity could explain this impairment.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W1997366308 created "2016-06-24" @default.
• W1997366308 creator A5004019662 @default.
• W1997366308 creator A5005563576 @default.
• W1997366308 creator A5028036103 @default.
• W1997366308 creator A5038290834 @default.
• W1997366308 creator A5084074058 @default.
• W1997366308 date "1993-01-01" @default.
• W1997366308 modified "2023-09-25" @default.
• W1997366308 title "Effect of changes in the intrahippocampal vasopressin on memory retrieval and relearning" @default.
• W1997366308 cites W1013312086 @default.
• W1997366308 cites W1965436925 @default.
• W1997366308 cites W1965694140 @default.
• W1997366308 cites W1972389227 @default.
• W1997366308 cites W1993985402 @default.
• W1997366308 cites W2003446839 @default.
• W1997366308 cites W2008097494 @default.
• W1997366308 cites W2014500609 @default.
• W1997366308 cites W2023151119 @default.
• W1997366308 cites W2031248034 @default.
• W1997366308 cites W2037712525 @default.
• W1997366308 cites W2037762199 @default.
• W1997366308 cites W2040570367 @default.
• W1997366308 cites W2042728930 @default.
• W1997366308 cites W2046364593 @default.
• W1997366308 cites W2047782979 @default.
• W1997366308 cites W2055611926 @default.
• W1997366308 cites W2065274527 @default.
• W1997366308 cites W2065569148 @default.
• W1997366308 cites W2070695206 @default.
• W1997366308 cites W2075522790 @default.
• W1997366308 cites W2077159347 @default.
• W1997366308 cites W2084014166 @default.
• W1997366308 cites W2090312166 @default.
• W1997366308 cites W2105172205 @default.
• W1997366308 cites W2105516426 @default.
• W1997366308 cites W2133537289 @default.
• W1997366308 cites W2142529490 @default.
• W1997366308 cites W2162632863 @default.
• W1997366308 cites W2170146128 @default.
• W1997366308 doi "https://doi.org/10.1016/0163-1047(93)91131-6" @default.
• W1997366308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8442731" @default.
• W1997366308 hasPublicationYear "1993" @default.
• W1997366308 type Work @default.
• W1997366308 sameAs 1997366308 @default.
• W1997366308 citedByCount "38" @default.
• W1997366308 countsByYear W19973663082013 @default.
• W1997366308 countsByYear W19973663082020 @default.
• W1997366308 countsByYear W19973663082022 @default.
• W1997366308 crossrefType "journal-article" @default.
• W1997366308 hasAuthorship W1997366308A5004019662 @default.
• W1997366308 hasAuthorship W1997366308A5005563576 @default.
• W1997366308 hasAuthorship W1997366308A5028036103 @default.
• W1997366308 hasAuthorship W1997366308A5038290834 @default.
• W1997366308 hasAuthorship W1997366308A5084074058 @default.
• W1997366308 hasConcept C118303440 @default.
• W1997366308 hasConcept C126322002 @default.
• W1997366308 hasConcept C134018914 @default.
• W1997366308 hasConcept C15744967 @default.
• W1997366308 hasConcept C169760540 @default.
• W1997366308 hasConcept C170493617 @default.
• W1997366308 hasConcept C2776370428 @default.
• W1997366308 hasConcept C2779144063 @default.
• W1997366308 hasConcept C2781161787 @default.
• W1997366308 hasConcept C62525196 @default.
• W1997366308 hasConcept C71924100 @default.
• W1997366308 hasConcept C86803240 @default.
• W1997366308 hasConceptScore W1997366308C118303440 @default.
• W1997366308 hasConceptScore W1997366308C126322002 @default.
• W1997366308 hasConceptScore W1997366308C134018914 @default.
• W1997366308 hasConceptScore W1997366308C15744967 @default.
• W1997366308 hasConceptScore W1997366308C169760540 @default.
• W1997366308 hasConceptScore W1997366308C170493617 @default.
• W1997366308 hasConceptScore W1997366308C2776370428 @default.
• W1997366308 hasConceptScore W1997366308C2779144063 @default.
• W1997366308 hasConceptScore W1997366308C2781161787 @default.
• W1997366308 hasConceptScore W1997366308C62525196 @default.
• W1997366308 hasConceptScore W1997366308C71924100 @default.
• W1997366308 hasConceptScore W1997366308C86803240 @default.
• W1997366308 hasIssue "1" @default.
• W1997366308 hasLocation W19973663081 @default.
• W1997366308 hasLocation W19973663082 @default.
• W1997366308 hasOpenAccess W1997366308 @default.
• W1997366308 hasPrimaryLocation W19973663081 @default.
• W1997366308 hasRelatedWork W1998351332 @default.
• W1997366308 hasRelatedWork W2009418740 @default.
• W1997366308 hasRelatedWork W2010709602 @default.
• W1997366308 hasRelatedWork W2032376964 @default.
• W1997366308 hasRelatedWork W2042425697 @default.
• W1997366308 hasRelatedWork W2044402316 @default.
• W1997366308 hasRelatedWork W2069292195 @default.
• W1997366308 hasRelatedWork W2088618831 @default.
• W1997366308 hasRelatedWork W330803729 @default.
• W1997366308 hasRelatedWork W2407537258 @default.
• W1997366308 hasVolume "59" @default.
• W1997366308 isParatext "false" @default.
• W1997366308 isRetracted "false" @default.
• W1997366308 magId "1997366308" @default.

• next