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- W1997370296 abstract "As the extrapyramidal side effects of antipsychotic drugs tend to di~nish with time, while the ~tipsychotic effects do not (Coleman and Hayes 1975), it seems plausible that the sources of these two phenomena lie in different regions of the brain. With the demonstration of dopaminergic terminals in the rat frontal cortex (Thierry et al. 1973), these neurons have become the focus of much research describing their functional properties and implicating them in the therapeutic action of neuroleptics. For example, it has been shown that rat pmfrontal cortex shows a smaller increase in dopamine metabolites upon acute drug administration (Bannon et al. 1983) and less tolerance to this effect upon chronic administration (Bannon et al. 1982) than other brain regions. More recently, however, certain authors (Laduron et al. 1977; Matsumoto et al. 1983; Chang et al. 1986) have suggested that the prefrontal cortex is preferentially sensitive to haloperidol at very low doses and that this unique propetty lends support to the assertion that this region is the site of action of neuro-" @default.
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- W1997370296 date "1989-03-01" @default.
- W1997370296 modified "2023-09-24" @default.
- W1997370296 title "Sensitivity of regional brain dopamine systems to haloperidol" @default.
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- W1997370296 doi "https://doi.org/10.1016/0006-3223(89)90258-8" @default.
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