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- W1997372802 endingPage "e25763" @default.
- W1997372802 startingPage "e25763" @default.
- W1997372802 abstract "Cytokines play several roles in developing and/or reinforcing premature cellular senescence of young cells. One such cytokine, interleukin-6 (IL-6), regulates senescence in some systems in addition to its known functions of immune regulation and promotion of tumorigenesis. In this review, we describe recent advances in studies on the roles of IL-6 and its downstream signal transducer and activator of transcription 3 (STAT3) in regulating premature cellular senescence. IL-6/sIL-6Rα stimulation forms a senescence-inducing circuit involving the STAT3-insulin-like growth factor-binding protein 5 (IGFBP5) as a key axis triggering and reinforcing component in human fibroblasts. We describe how cytokines regulate the process of senescence by activating STAT3 in one system and anti-senescence or tumorigenesis in other systems. The roles of other STAT members in premature senescence also will be discussed to show the multiple mechanisms leading to cytokine-induced senescence." @default.
- W1997372802 created "2016-06-24" @default.
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- W1997372802 creator A5072055558 @default.
- W1997372802 date "2013-10-16" @default.
- W1997372802 modified "2023-10-17" @default.
- W1997372802 title "IL-6-STAT3 signaling and premature senescence" @default.
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- W1997372802 doi "https://doi.org/10.4161/jkst.25763" @default.
- W1997372802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3876432" @default.
- W1997372802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24416650" @default.
- W1997372802 hasPublicationYear "2013" @default.