FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997386937> ?p ?o ?g. }

• W1997386937 endingPage "e75148" @default.
• W1997386937 startingPage "e75148" @default.
• W1997386937 abstract "Prophylactic vaccinations are generally performed to protect naïve individuals with or without suppressed immune responsiveness. In a mouse model for Influenza vaccinations the specific alterations of CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Tregs) in the immune modulation induced by orally supplied oligosaccharides containing scGOS/lcFOS/pAOS was assessed. This dietary intervention increased vaccine specific DTH responses. In addition, a significant increased percentage of T-bet(+) (Th1) activated CD69(+)CD4(+) T cells (p<0.001) and reduced percentage of Gata-3(+) (Th2) activated CD69(+)CD4(+)T cells (p<0.001) was detected in the mesenteric lymph nodes (MLN) of mice receiving scGOS/lcFOS/pAOS compared to control mice. Although no difference in the number or percentage of Tregs (CD4(+)Foxp3(+)) could be determined after scGOS/lcFOS/pAOS intervention, the percentage of CXCR3 (+) /T-bet(+) (Th1-Tregs) was significantly reduced (p<0.05) in mice receiving scGOS/lcFOS/pAOS as compared to mice receiving placebo diets. Moreover, although no absolute difference in suppressive capacity could be detected, an alteration in cytokine profile suggests a regulatory T cell shift towards a reducing Th1 suppression profile, supporting an improved vaccination response.These data are indicative for improved vaccine responsiveness due to reduced Th1 suppressive capacity in the Treg population of mice fed the oligosaccharide specific diet, showing compartmentalization within the Treg population. The modulation of Tregs to control immune responses provides an additional arm of intervention using alternative strategies possibly leading to the development of improved vaccines." @default.
• W1997386937 created "2016-06-24" @default.
• W1997386937 creator A5023267835 @default.
• W1997386937 creator A5025153030 @default.
• W1997386937 creator A5025197980 @default.
• W1997386937 creator A5032023273 @default.
• W1997386937 creator A5041501080 @default.
• W1997386937 creator A5049212449 @default.
• W1997386937 creator A5051105540 @default.
• W1997386937 creator A5051707428 @default.
• W1997386937 creator A5061793996 @default.
• W1997386937 creator A5084917793 @default.
• W1997386937 date "2013-09-20" @default.
• W1997386937 modified "2023-10-13" @default.
• W1997386937 title "Alterations in Regulatory T Cells Induced by Specific Oligosaccharides Improve Vaccine Responsiveness in Mice" @default.
• W1997386937 cites W1501511128 @default.
• W1997386937 cites W1635103958 @default.
• W1997386937 cites W1969954634 @default.
• W1997386937 cites W1971613814 @default.
• W1997386937 cites W1986130378 @default.
• W1997386937 cites W1987735044 @default.
• W1997386937 cites W1993959730 @default.
• W1997386937 cites W1997058116 @default.
• W1997386937 cites W2014540704 @default.
• W1997386937 cites W2029640857 @default.
• W1997386937 cites W2034635728 @default.
• W1997386937 cites W2063679726 @default.
• W1997386937 cites W2067818823 @default.
• W1997386937 cites W2071347193 @default.
• W1997386937 cites W2075703130 @default.
• W1997386937 cites W2076355973 @default.
• W1997386937 cites W2078929498 @default.
• W1997386937 cites W2080935386 @default.
• W1997386937 cites W2101779729 @default.
• W1997386937 cites W2102179509 @default.
• W1997386937 cites W2116973575 @default.
• W1997386937 cites W2129343238 @default.
• W1997386937 cites W2143589197 @default.
• W1997386937 cites W2160670021 @default.
• W1997386937 cites W2165472257 @default.
• W1997386937 doi "https://doi.org/10.1371/journal.pone.0075148" @default.
• W1997386937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3779252" @default.
• W1997386937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24073243" @default.
• W1997386937 hasPublicationYear "2013" @default.
• W1997386937 type Work @default.
• W1997386937 sameAs 1997386937 @default.
• W1997386937 citedByCount "13" @default.
• W1997386937 countsByYear W19973869372013 @default.
• W1997386937 countsByYear W19973869372014 @default.
• W1997386937 countsByYear W19973869372016 @default.
• W1997386937 countsByYear W19973869372018 @default.
• W1997386937 countsByYear W19973869372021 @default.
• W1997386937 countsByYear W19973869372022 @default.
• W1997386937 crossrefType "journal-article" @default.
• W1997386937 hasAuthorship W1997386937A5023267835 @default.
• W1997386937 hasAuthorship W1997386937A5025153030 @default.
• W1997386937 hasAuthorship W1997386937A5025197980 @default.
• W1997386937 hasAuthorship W1997386937A5032023273 @default.
• W1997386937 hasAuthorship W1997386937A5041501080 @default.
• W1997386937 hasAuthorship W1997386937A5049212449 @default.
• W1997386937 hasAuthorship W1997386937A5051105540 @default.
• W1997386937 hasAuthorship W1997386937A5051707428 @default.
• W1997386937 hasAuthorship W1997386937A5061793996 @default.
• W1997386937 hasAuthorship W1997386937A5084917793 @default.
• W1997386937 hasBestOaLocation W19973869371 @default.
• W1997386937 hasConcept C203014093 @default.
• W1997386937 hasConcept C22070199 @default.
• W1997386937 hasConcept C2776090121 @default.
• W1997386937 hasConcept C2778296632 @default.
• W1997386937 hasConcept C2779727006 @default.
• W1997386937 hasConcept C2908647359 @default.
• W1997386937 hasConcept C71924100 @default.
• W1997386937 hasConcept C79484868 @default.
• W1997386937 hasConcept C86803240 @default.
• W1997386937 hasConcept C8891405 @default.
• W1997386937 hasConcept C99454951 @default.
• W1997386937 hasConceptScore W1997386937C203014093 @default.
• W1997386937 hasConceptScore W1997386937C22070199 @default.
• W1997386937 hasConceptScore W1997386937C2776090121 @default.
• W1997386937 hasConceptScore W1997386937C2778296632 @default.
• W1997386937 hasConceptScore W1997386937C2779727006 @default.
• W1997386937 hasConceptScore W1997386937C2908647359 @default.
• W1997386937 hasConceptScore W1997386937C71924100 @default.
• W1997386937 hasConceptScore W1997386937C79484868 @default.
• W1997386937 hasConceptScore W1997386937C86803240 @default.
• W1997386937 hasConceptScore W1997386937C8891405 @default.
• W1997386937 hasConceptScore W1997386937C99454951 @default.
• W1997386937 hasIssue "9" @default.
• W1997386937 hasLocation W19973869371 @default.
• W1997386937 hasLocation W19973869372 @default.
• W1997386937 hasLocation W19973869373 @default.
• W1997386937 hasLocation W19973869374 @default.
• W1997386937 hasLocation W19973869375 @default.
• W1997386937 hasOpenAccess W1997386937 @default.
• W1997386937 hasPrimaryLocation W19973869371 @default.
• W1997386937 hasRelatedWork W136737509 @default.
• W1997386937 hasRelatedWork W1523292317 @default.
• W1997386937 hasRelatedWork W1591511991 @default.

• next