Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997393323> ?p ?o ?g. }
- W1997393323 endingPage "227" @default.
- W1997393323 startingPage "219" @default.
- W1997393323 abstract "The aim of the present work was to investigate the role of brain μ, κ and δ opioid receptors in the central serotonergic mechanisms regulating blood pressure in rats. The data obtained show that: (1) pharmacological activation of central 5-HT(3) receptors yields a significant decrease in blood pressure; (2) the blockade of those receptors by a selective antagonist induces an acute hypertensive response; (3) the pharmacological blockade of central opioid receptors by three different opioid antagonists exhibiting variable degrees of selectivity to μ, κ and δ opioid receptors always suppressed the hypotensive response induced by central 5-HT(3) receptor stimulation; (4) the blockade of opioid receptors by the same opioid antagonists that impaired the hypotensive effect of central 5-HT(3) receptor stimulation failed to modify blood pressure in animals not submitted to pharmacological manipulations of central 5-HT(3) receptor function. It is shown that a 5-HT(3) receptor-dependent mechanism seems to be part of the brain serotonergic system that contributes to cardiovascular regulation since the hypertensive response observed after ondansetron administration indicates that central 5-HT(3) receptors exert a tonic inhibitory drive on blood pressure. Furthermore, the data obtained here clearly indicate that the hypotensive response observed after pharmacological stimulation of central 5-HT(3) receptors depends on the functional integrity of brain μ, κ and δ opioid receptors, suggesting that a functional interaction between serotonergic and opiatergic pathways in the brain is part of the complex, multifactorial system that regulates blood pressure in the central nervous system." @default.
- W1997393323 created "2016-06-24" @default.
- W1997393323 creator A5007011523 @default.
- W1997393323 creator A5045066097 @default.
- W1997393323 creator A5056446582 @default.
- W1997393323 creator A5060426076 @default.
- W1997393323 creator A5067758095 @default.
- W1997393323 date "2011-06-01" @default.
- W1997393323 modified "2023-09-27" @default.
- W1997393323 title "Multiple opioid receptors mediate the hypotensive response induced by central 5-HT3 receptor stimulation" @default.
- W1997393323 cites W1462735181 @default.
- W1997393323 cites W1499203998 @default.
- W1997393323 cites W1577495336 @default.
- W1997393323 cites W1965909983 @default.
- W1997393323 cites W1969553615 @default.
- W1997393323 cites W1971646691 @default.
- W1997393323 cites W1974908118 @default.
- W1997393323 cites W1977163272 @default.
- W1997393323 cites W1979031324 @default.
- W1997393323 cites W1980075929 @default.
- W1997393323 cites W1981595251 @default.
- W1997393323 cites W1988800128 @default.
- W1997393323 cites W1990061504 @default.
- W1997393323 cites W1997428559 @default.
- W1997393323 cites W1998462092 @default.
- W1997393323 cites W1999142590 @default.
- W1997393323 cites W2006065882 @default.
- W1997393323 cites W2008243901 @default.
- W1997393323 cites W2014110722 @default.
- W1997393323 cites W2015994122 @default.
- W1997393323 cites W2025449803 @default.
- W1997393323 cites W2027842014 @default.
- W1997393323 cites W2034989225 @default.
- W1997393323 cites W2037963154 @default.
- W1997393323 cites W2038322363 @default.
- W1997393323 cites W2040917465 @default.
- W1997393323 cites W2042729397 @default.
- W1997393323 cites W2043364141 @default.
- W1997393323 cites W2045048871 @default.
- W1997393323 cites W2046647573 @default.
- W1997393323 cites W2054411226 @default.
- W1997393323 cites W2058905596 @default.
- W1997393323 cites W2062566582 @default.
- W1997393323 cites W2063899996 @default.
- W1997393323 cites W2064644850 @default.
- W1997393323 cites W2064983590 @default.
- W1997393323 cites W2065716899 @default.
- W1997393323 cites W2065876632 @default.
- W1997393323 cites W2068263796 @default.
- W1997393323 cites W2069027411 @default.
- W1997393323 cites W2070348461 @default.
- W1997393323 cites W2071046743 @default.
- W1997393323 cites W2074431255 @default.
- W1997393323 cites W2074849270 @default.
- W1997393323 cites W2076101724 @default.
- W1997393323 cites W2076990565 @default.
- W1997393323 cites W2079120217 @default.
- W1997393323 cites W2079578324 @default.
- W1997393323 cites W2080491963 @default.
- W1997393323 cites W2082853303 @default.
- W1997393323 cites W2084757489 @default.
- W1997393323 cites W2085513213 @default.
- W1997393323 cites W2085754416 @default.
- W1997393323 cites W2088896064 @default.
- W1997393323 cites W2090706622 @default.
- W1997393323 cites W2093410737 @default.
- W1997393323 cites W2095153551 @default.
- W1997393323 cites W2101328289 @default.
- W1997393323 cites W2104346407 @default.
- W1997393323 cites W2114382165 @default.
- W1997393323 cites W2116819517 @default.
- W1997393323 cites W2119601193 @default.
- W1997393323 cites W2120104122 @default.
- W1997393323 cites W2126484653 @default.
- W1997393323 cites W2132027342 @default.
- W1997393323 cites W2140257707 @default.
- W1997393323 cites W2166729000 @default.
- W1997393323 cites W2170165650 @default.
- W1997393323 cites W2321002049 @default.
- W1997393323 cites W2418104482 @default.
- W1997393323 cites W2772887788 @default.
- W1997393323 doi "https://doi.org/10.1016/j.npep.2011.03.004" @default.
- W1997393323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21514668" @default.
- W1997393323 hasPublicationYear "2011" @default.
- W1997393323 type Work @default.
- W1997393323 sameAs 1997393323 @default.
- W1997393323 citedByCount "10" @default.
- W1997393323 countsByYear W19973933232012 @default.
- W1997393323 countsByYear W19973933232014 @default.
- W1997393323 countsByYear W19973933232015 @default.
- W1997393323 countsByYear W19973933232018 @default.
- W1997393323 countsByYear W19973933232021 @default.
- W1997393323 countsByYear W19973933232023 @default.
- W1997393323 crossrefType "journal-article" @default.
- W1997393323 hasAuthorship W1997393323A5007011523 @default.
- W1997393323 hasAuthorship W1997393323A5045066097 @default.
- W1997393323 hasAuthorship W1997393323A5056446582 @default.
- W1997393323 hasAuthorship W1997393323A5060426076 @default.