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- W1997400622 endingPage "1360" @default.
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- W1997400622 abstract "The thymus provides the microenvironment in which thymocytes develop into mature T-cells, and interactions with thymic stromal cells are thought to provide the necessary signals for thymocyte maturation. Recognition of self-MHC by T-cells is a basic requirement for mature T-cell functions, and those thymocytes that do not recognize or respond too strongly to the peptide-loaded self-MHC molecules found in the thymus undergo apoptosis. As a result, 95% of the thymocytes produced will die and be subsequently cleared by macrophages. This review describes a complex crosstalk between developing thymocytes and engulfing macrophages which is mediated by retinoids produced by engulfing macrophages. The interaction results in the harmonization of the rate of cell death of dying double positive cells with their clearance and replacement, and in promotion of the differentiation of the selected cells in the thymus." @default.
- W1997400622 created "2016-06-24" @default.
- W1997400622 creator A5033585028 @default.
- W1997400622 creator A5046697756 @default.
- W1997400622 creator A5052962131 @default.
- W1997400622 creator A5053771439 @default.
- W1997400622 creator A5059364953 @default.
- W1997400622 creator A5066726531 @default.
- W1997400622 creator A5086800174 @default.
- W1997400622 date "2013-11-01" @default.
- W1997400622 modified "2023-09-25" @default.
- W1997400622 title "Macrophages engulfing apoptotic thymocytes produce retinoids to promote selection, differentiation, removal and replacement of double positive thymocytes" @default.
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- W1997400622 doi "https://doi.org/10.1016/j.imbio.2013.06.009" @default.
- W1997400622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23932496" @default.
- W1997400622 hasPublicationYear "2013" @default.
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