FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997408181> ?p ?o ?g. }

• W1997408181 endingPage "4200" @default.
• W1997408181 startingPage "4191" @default.
• W1997408181 abstract "A nozzle for a spray dryer that can prepare microparticles of water-soluble carriers containing various nanoparticles in a single step was previously developed in our laboratory. To enhance the solubility and intestinal absorption of poorly water-soluble drugs, we used probucol (PBL) as a poorly water-soluble drug, mannitol (MAN) as a water-soluble carrier for the microparticles, and EUDRAGIT (EUD) as a polymer vehicle for the solid dispersion. PBL–EUD–acetone–methanol and aqueous MAN solutions were simultaneously supplied through different liquid passages of the spray nozzle and dried together. PBL–EUD solid dispersion was nanoprecipitated in the MAN solution using an antisolvent mechanism and rapidly dried by surrounding it with MAN. PBL in the dispersion vehicle was amorphous and had higher physical stability according to powder X-ray diffraction and differential scanning calorimetry analysis. The bioavailability of PBL in PBL–EUD S-100–MAN microparticles after oral administration in rats was markedly higher (14- and 6.2-fold, respectively) than that of the original PBL powder and PBL–MAN microparticles. These results demonstrate that the composite microparticles containing a nanosized solid dispersion of a poorly water-soluble drug prepared using the spray nozzle developed by us should be useful to increase the solubility and bioavailability of drugs after oral administration." @default.
• W1997408181 created "2016-06-24" @default.
• W1997408181 creator A5001867431 @default.
• W1997408181 creator A5013308819 @default.
• W1997408181 creator A5015048930 @default.
• W1997408181 creator A5019144182 @default.
• W1997408181 creator A5069857354 @default.
• W1997408181 creator A5090988844 @default.
• W1997408181 date "2012-11-01" @default.
• W1997408181 modified "2023-10-14" @default.
• W1997408181 title "Improved Intestinal Absorption of a Poorly Water-Soluble Oral Drug Using Mannitol Microparticles Containing A Nanosolid Drug Dispersion" @default.
• W1997408181 cites W1498305210 @default.
• W1997408181 cites W1905674946 @default.
• W1997408181 cites W1965798116 @default.
• W1997408181 cites W1971406051 @default.
• W1997408181 cites W1975917557 @default.
• W1997408181 cites W1976544366 @default.
• W1997408181 cites W1979657535 @default.
• W1997408181 cites W1979791843 @default.
• W1997408181 cites W1982850799 @default.
• W1997408181 cites W1991916654 @default.
• W1997408181 cites W2001596955 @default.
• W1997408181 cites W2015626644 @default.
• W1997408181 cites W2020337784 @default.
• W1997408181 cites W2040432233 @default.
• W1997408181 cites W2044475288 @default.
• W1997408181 cites W2055444002 @default.
• W1997408181 cites W2058688073 @default.
• W1997408181 cites W2064802984 @default.
• W1997408181 cites W2067777829 @default.
• W1997408181 cites W2074516481 @default.
• W1997408181 cites W2074582913 @default.
• W1997408181 cites W2075333700 @default.
• W1997408181 cites W2084333618 @default.
• W1997408181 cites W2088967093 @default.
• W1997408181 cites W2156829937 @default.
• W1997408181 cites W2158129487 @default.
• W1997408181 cites W2952528349 @default.
• W1997408181 cites W4251505294 @default.
• W1997408181 cites W4376849571 @default.
• W1997408181 cites W63350312 @default.
• W1997408181 doi "https://doi.org/10.1002/jps.23278" @default.
• W1997408181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22864998" @default.
• W1997408181 hasPublicationYear "2012" @default.
• W1997408181 type Work @default.
• W1997408181 sameAs 1997408181 @default.
• W1997408181 citedByCount "13" @default.
• W1997408181 countsByYear W19974081812013 @default.
• W1997408181 countsByYear W19974081812014 @default.
• W1997408181 countsByYear W19974081812016 @default.
• W1997408181 countsByYear W19974081812017 @default.
• W1997408181 countsByYear W19974081812018 @default.
• W1997408181 countsByYear W19974081812019 @default.
• W1997408181 crossrefType "journal-article" @default.
• W1997408181 hasAuthorship W1997408181A5001867431 @default.
• W1997408181 hasAuthorship W1997408181A5013308819 @default.
• W1997408181 hasAuthorship W1997408181A5015048930 @default.
• W1997408181 hasAuthorship W1997408181A5019144182 @default.
• W1997408181 hasAuthorship W1997408181A5069857354 @default.
• W1997408181 hasAuthorship W1997408181A5090988844 @default.
• W1997408181 hasConcept C120665830 @default.
• W1997408181 hasConcept C121332964 @default.
• W1997408181 hasConcept C125287762 @default.
• W1997408181 hasConcept C127413603 @default.
• W1997408181 hasConcept C13965031 @default.
• W1997408181 hasConcept C155574463 @default.
• W1997408181 hasConcept C159985019 @default.
• W1997408181 hasConcept C177562468 @default.
• W1997408181 hasConcept C178790620 @default.
• W1997408181 hasConcept C181389837 @default.
• W1997408181 hasConcept C184651966 @default.
• W1997408181 hasConcept C185592680 @default.
• W1997408181 hasConcept C192562407 @default.
• W1997408181 hasConcept C2778445172 @default.
• W1997408181 hasConcept C2779587474 @default.
• W1997408181 hasConcept C3020651653 @default.
• W1997408181 hasConcept C39519442 @default.
• W1997408181 hasConcept C42360764 @default.
• W1997408181 hasConcept C43617362 @default.
• W1997408181 hasConcept C71924100 @default.
• W1997408181 hasConcept C77281830 @default.
• W1997408181 hasConcept C97355855 @default.
• W1997408181 hasConcept C98274493 @default.
• W1997408181 hasConceptScore W1997408181C120665830 @default.
• W1997408181 hasConceptScore W1997408181C121332964 @default.
• W1997408181 hasConceptScore W1997408181C125287762 @default.
• W1997408181 hasConceptScore W1997408181C127413603 @default.
• W1997408181 hasConceptScore W1997408181C13965031 @default.
• W1997408181 hasConceptScore W1997408181C155574463 @default.
• W1997408181 hasConceptScore W1997408181C159985019 @default.
• W1997408181 hasConceptScore W1997408181C177562468 @default.
• W1997408181 hasConceptScore W1997408181C178790620 @default.
• W1997408181 hasConceptScore W1997408181C181389837 @default.
• W1997408181 hasConceptScore W1997408181C184651966 @default.
• W1997408181 hasConceptScore W1997408181C185592680 @default.
• W1997408181 hasConceptScore W1997408181C192562407 @default.
• W1997408181 hasConceptScore W1997408181C2778445172 @default.
• W1997408181 hasConceptScore W1997408181C2779587474 @default.

• next