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- W1997422013 abstract "Horseradish peroxidase (mol wt 40,000) was injected intravenously as a permeability tracer to examine the function of the blood-nerve barriers after 4 and 22 weeks of galactose feeding. Galactose-fed rats developed, as expected, abnormalities including bilateral cataract, a significant decrease in nerve conduction velocity, significant increases in nerve wet weight and water content, and increases in the area between myelinated fibers. In addition, the number of endoneurial mast cells per unit area increased considerably. However, the endoneurial blood vessels and the perineurium continued to provide effective barriers to the penetration of horseradish peroxidase into the extracellular space of the nerve fascicles in all the galactose-fed rats. In diabetic neuropathy and in galactose-fed rats, sugar alcohols are known to accumulate in peripheral nerve. Intact diffusion barriers would contribute to the accumulation of these substances within the endoneurium of galactose-fed rats. Consequently these barriers may play an important role in the etiology of the peripheral neuropathy observed in galactose-fed rats and in diabetic peripheral neuropathy as well." @default.
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- W1997422013 date "1979-12-01" @default.
- W1997422013 modified "2023-09-23" @default.
- W1997422013 title "Permeability of blood-nerve barrier in galactose-fed rats" @default.
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- W1997422013 doi "https://doi.org/10.1016/0014-4886(79)90219-x" @default.
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