FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997423629> ?p ?o ?g. }

• W1997423629 endingPage "4425" @default.
• W1997423629 startingPage "4421" @default.
• W1997423629 abstract "The binding of a steroid hormone to its receptor elicits a sequence of events: activation of the receptor (probably through dissociation from a complex of heat shock proteins), dimerization, binding to hormone responsive elements, and finally modulation of gene transcription. RU 486, the first antiprogestin studied, has been shown to act at the last step of this sequence: provoking an inefficient binding of the receptor to hormone responsive elements. Recently, based on in vitro studies, it has been proposed that ZK 98299 was the prototype of a second class of antiprogestins that were supposed to act through disruption of the binding to DNA. We have devised methods allowing us to study the various steps of agonist or antagonist action in vivo. We show here that RU 486 and ZK 98299 have the same effects on receptor activation, dimerization, and binding to hormone responsive elements; differences in their action are explained by the 10-fold difference in their affinity for the receptor (ZK 98299 having the lower affinity)." @default.
• W1997423629 created "2016-06-24" @default.
• W1997423629 creator A5004692465 @default.
• W1997423629 creator A5023252170 @default.
• W1997423629 creator A5062218852 @default.
• W1997423629 date "1993-05-15" @default.
• W1997423629 modified "2023-10-18" @default.
• W1997423629 title "In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA." @default.
• W1997423629 cites W1492607760 @default.
• W1997423629 cites W1550805443 @default.
• W1997423629 cites W1554212009 @default.
• W1997423629 cites W1849261438 @default.
• W1997423629 cites W1965372133 @default.
• W1997423629 cites W1966345224 @default.
• W1997423629 cites W1978038538 @default.
• W1997423629 cites W1988160921 @default.
• W1997423629 cites W2001099922 @default.
• W1997423629 cites W2001859124 @default.
• W1997423629 cites W2002357201 @default.
• W1997423629 cites W2002651126 @default.
• W1997423629 cites W2003345409 @default.
• W1997423629 cites W2005369865 @default.
• W1997423629 cites W2007048730 @default.
• W1997423629 cites W2007587099 @default.
• W1997423629 cites W2016141882 @default.
• W1997423629 cites W2029669301 @default.
• W1997423629 cites W2037404178 @default.
• W1997423629 cites W2038939638 @default.
• W1997423629 cites W2048827709 @default.
• W1997423629 cites W2055777033 @default.
• W1997423629 cites W2063559733 @default.
• W1997423629 cites W2066441904 @default.
• W1997423629 cites W2071525868 @default.
• W1997423629 cites W2071648065 @default.
• W1997423629 cites W2073836271 @default.
• W1997423629 cites W2082121884 @default.
• W1997423629 cites W2087250746 @default.
• W1997423629 cites W2088167128 @default.
• W1997423629 cites W2088622701 @default.
• W1997423629 cites W2090603595 @default.
• W1997423629 cites W2123015098 @default.
• W1997423629 cites W2135564507 @default.
• W1997423629 cites W2144206181 @default.
• W1997423629 cites W2401438415 @default.
• W1997423629 cites W2403970471 @default.
• W1997423629 cites W74071586 @default.
• W1997423629 doi "https://doi.org/10.1073/pnas.90.10.4421" @default.
• W1997423629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/46523" @default.
• W1997423629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8506282" @default.
• W1997423629 hasPublicationYear "1993" @default.
• W1997423629 type Work @default.
• W1997423629 sameAs 1997423629 @default.
• W1997423629 citedByCount "46" @default.
• W1997423629 countsByYear W19974236292023 @default.
• W1997423629 crossrefType "journal-article" @default.
• W1997423629 hasAuthorship W1997423629A5004692465 @default.
• W1997423629 hasAuthorship W1997423629A5023252170 @default.
• W1997423629 hasAuthorship W1997423629A5062218852 @default.
• W1997423629 hasBestOaLocation W19974236291 @default.
• W1997423629 hasConcept C104317684 @default.
• W1997423629 hasConcept C121608353 @default.
• W1997423629 hasConcept C170493617 @default.
• W1997423629 hasConcept C185592680 @default.
• W1997423629 hasConcept C207001950 @default.
• W1997423629 hasConcept C2778938600 @default.
• W1997423629 hasConcept C51445715 @default.
• W1997423629 hasConcept C530470458 @default.
• W1997423629 hasConcept C54355233 @default.
• W1997423629 hasConcept C552990157 @default.
• W1997423629 hasConcept C55493867 @default.
• W1997423629 hasConcept C71315377 @default.
• W1997423629 hasConcept C84606932 @default.
• W1997423629 hasConcept C86339819 @default.
• W1997423629 hasConcept C86803240 @default.
• W1997423629 hasConcept C95444343 @default.
• W1997423629 hasConceptScore W1997423629C104317684 @default.
• W1997423629 hasConceptScore W1997423629C121608353 @default.
• W1997423629 hasConceptScore W1997423629C170493617 @default.
• W1997423629 hasConceptScore W1997423629C185592680 @default.
• W1997423629 hasConceptScore W1997423629C207001950 @default.
• W1997423629 hasConceptScore W1997423629C2778938600 @default.
• W1997423629 hasConceptScore W1997423629C51445715 @default.
• W1997423629 hasConceptScore W1997423629C530470458 @default.
• W1997423629 hasConceptScore W1997423629C54355233 @default.
• W1997423629 hasConceptScore W1997423629C552990157 @default.
• W1997423629 hasConceptScore W1997423629C55493867 @default.
• W1997423629 hasConceptScore W1997423629C71315377 @default.
• W1997423629 hasConceptScore W1997423629C84606932 @default.
• W1997423629 hasConceptScore W1997423629C86339819 @default.
• W1997423629 hasConceptScore W1997423629C86803240 @default.
• W1997423629 hasConceptScore W1997423629C95444343 @default.
• W1997423629 hasIssue "10" @default.
• W1997423629 hasLocation W19974236291 @default.
• W1997423629 hasLocation W19974236292 @default.
• W1997423629 hasLocation W19974236293 @default.
• W1997423629 hasLocation W19974236294 @default.
• W1997423629 hasOpenAccess W1997423629 @default.
• W1997423629 hasPrimaryLocation W19974236291 @default.

• next