FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997424892> ?p ?o ?g. }

• W1997424892 endingPage "624" @default.
• W1997424892 startingPage "613" @default.
• W1997424892 abstract "Ghrelin, a newly isolated brain-gut peptide, has been found to play important roles in the male reproduction. However, to date, the detailed mechanisms still remain unknown. In this study, we identified a novel functional role of ghrelin in modulating T-type Ca²⁺ channel currents (T-currents) in mouse spermatogenic cells. We found that ghrelin inhibited T-currents in a dose-dependent manner. Ghrelin at 0.1 µM reversibly inhibited T-currents by ∼31.7%. This inhibitory effect was blocked by D-Lys3-GHRP-6, a selective growth hormone secretagogue receptor 1a (GHS-R1a) antagonist. Intracellular infusion of GDP-b-S or pretreatment of the cells with pertussis toxin (PTX) completely blocked the inhibitory effects of ghrelin. Furthermore, ghrelin responses were abolished by the phospholipase C inhibitor U73122, but not the inactive analogue U73343. The classical and novel protein kinase C antagonist chelerythrine chlorid or GF109203X abolished ghrelin responses, whereas Ro31-8820, a classical PKC antagonist or PKI 6-22, a PKA antagonist, elicited no such effects. Taken together, these results suggest that ghrelin acting through GSH-R1a inhibits T-currents via a PTX-sensitive novel PKC pathway in mouse spermatogenic cells, which could contribute to its male reproductive functions such as acrosome reactions." @default.
• W1997424892 created "2016-06-24" @default.
• W1997424892 creator A5009309367 @default.
• W1997424892 creator A5022515556 @default.
• W1997424892 creator A5035316499 @default.
• W1997424892 creator A5080823195 @default.
• W1997424892 creator A5088174174 @default.
• W1997424892 creator A5088866683 @default.
• W1997424892 date "2011-01-01" @default.
• W1997424892 modified "2023-09-26" @default.
• W1997424892 title "Activation of Growth Hormone Secretagogue Type 1a Receptor Inhibits T-type Ca²⁺ Channel Currents through Pertussis Toxin-sensitive Novel Protein Kinase C Pathway in Mouse Spermatogenic Cells" @default.
• W1997424892 cites W1535117441 @default.
• W1997424892 cites W1715376164 @default.
• W1997424892 cites W1973036704 @default.
• W1997424892 cites W1989237770 @default.
• W1997424892 cites W1991509515 @default.
• W1997424892 cites W1994530674 @default.
• W1997424892 cites W1994684831 @default.
• W1997424892 cites W2000165376 @default.
• W1997424892 cites W2020434990 @default.
• W1997424892 cites W2028865219 @default.
• W1997424892 cites W2031585557 @default.
• W1997424892 cites W2032685543 @default.
• W1997424892 cites W2032787062 @default.
• W1997424892 cites W2037248258 @default.
• W1997424892 cites W2044816049 @default.
• W1997424892 cites W2048090775 @default.
• W1997424892 cites W2055703635 @default.
• W1997424892 cites W2063841104 @default.
• W1997424892 cites W2065162620 @default.
• W1997424892 cites W2080694066 @default.
• W1997424892 cites W2090639515 @default.
• W1997424892 cites W2094319133 @default.
• W1997424892 cites W2104591201 @default.
• W1997424892 cites W2138778382 @default.
• W1997424892 cites W2140040791 @default.
• W1997424892 cites W2163865122 @default.
• W1997424892 cites W2293374437 @default.
• W1997424892 cites W2337305121 @default.
• W1997424892 cites W2338721191 @default.
• W1997424892 cites W2418100888 @default.
• W1997424892 cites W3150774544 @default.
• W1997424892 cites W4235804678 @default.
• W1997424892 cites W4239095299 @default.
• W1997424892 cites W4244695012 @default.
• W1997424892 doi "https://doi.org/10.1159/000329983" @default.
• W1997424892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21691079" @default.
• W1997424892 hasPublicationYear "2011" @default.
• W1997424892 type Work @default.
• W1997424892 sameAs 1997424892 @default.
• W1997424892 citedByCount "9" @default.
• W1997424892 countsByYear W19974248922012 @default.
• W1997424892 countsByYear W19974248922013 @default.
• W1997424892 countsByYear W19974248922014 @default.
• W1997424892 countsByYear W19974248922017 @default.
• W1997424892 countsByYear W19974248922018 @default.
• W1997424892 countsByYear W19974248922021 @default.
• W1997424892 countsByYear W19974248922022 @default.
• W1997424892 crossrefType "journal-article" @default.
• W1997424892 hasAuthorship W1997424892A5009309367 @default.
• W1997424892 hasAuthorship W1997424892A5022515556 @default.
• W1997424892 hasAuthorship W1997424892A5035316499 @default.
• W1997424892 hasAuthorship W1997424892A5080823195 @default.
• W1997424892 hasAuthorship W1997424892A5088174174 @default.
• W1997424892 hasAuthorship W1997424892A5088866683 @default.
• W1997424892 hasBestOaLocation W19974248921 @default.
• W1997424892 hasConcept C126322002 @default.
• W1997424892 hasConcept C134018914 @default.
• W1997424892 hasConcept C170493617 @default.
• W1997424892 hasConcept C184235292 @default.
• W1997424892 hasConcept C185592680 @default.
• W1997424892 hasConcept C195794163 @default.
• W1997424892 hasConcept C2776108454 @default.
• W1997424892 hasConcept C2776885963 @default.
• W1997424892 hasConcept C2779168441 @default.
• W1997424892 hasConcept C2779357093 @default.
• W1997424892 hasConcept C2780161494 @default.
• W1997424892 hasConcept C49039625 @default.
• W1997424892 hasConcept C49773422 @default.
• W1997424892 hasConcept C62478195 @default.
• W1997424892 hasConcept C71315377 @default.
• W1997424892 hasConcept C71924100 @default.
• W1997424892 hasConcept C80631254 @default.
• W1997424892 hasConcept C86803240 @default.
• W1997424892 hasConcept C95444343 @default.
• W1997424892 hasConcept C97029542 @default.
• W1997424892 hasConceptScore W1997424892C126322002 @default.
• W1997424892 hasConceptScore W1997424892C134018914 @default.
• W1997424892 hasConceptScore W1997424892C170493617 @default.
• W1997424892 hasConceptScore W1997424892C184235292 @default.
• W1997424892 hasConceptScore W1997424892C185592680 @default.
• W1997424892 hasConceptScore W1997424892C195794163 @default.
• W1997424892 hasConceptScore W1997424892C2776108454 @default.
• W1997424892 hasConceptScore W1997424892C2776885963 @default.
• W1997424892 hasConceptScore W1997424892C2779168441 @default.
• W1997424892 hasConceptScore W1997424892C2779357093 @default.
• W1997424892 hasConceptScore W1997424892C2780161494 @default.
• W1997424892 hasConceptScore W1997424892C49039625 @default.

• next