FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997425045> ?p ?o ?g. }

• W1997425045 endingPage "129" @default.
• W1997425045 startingPage "121" @default.
• W1997425045 abstract "Nonalcoholic steatohepatitis (NASH) is a chronic progressive liver disease that is strongly associated with obesity. Currently, there is no approved therapy for NASH. Weight reduction is typically recommended, but efficacy data are lacking. We performed a randomized controlled trial to examine the effects of lifestyle intervention using a combination of diet, exercise, and behavior modification, with a goal of 7% to 10% weight reduction, on clinical parameters of NASH. The primary outcome measure was the change in NASH histological activity score (NAS) after 48 weeks of intervention. Thirty-one overweight or obese individuals (body mass index [BMI], 25-40 kg/m(2)) with biopsy-proven NASH were randomized in a 2:1 ratio to receive intensive lifestyle intervention (LS) or structured education (control). After 48 weeks of intervention, participants assigned to LS lost an average of 9.3% of their weight versus 0.2% in the control group (P = 0.003). A higher proportion of participants in the LS group had a reduction of NAS of at least 3 points or had posttreatment NAS of 2 or less as compared with the control group (72% versus 30%, P = 0.03). NAS improved significantly in the LS group (from 4.4 to 2.0) in comparison with the control group (from 4.9 to 3.5) (P = 0.05). Percent weight reduction correlated significantly with improvement in NAS (r = 0.497, P = 0.007). Participants who achieved the study weight loss goal (>or=7%), compared with those who lost less than 7%, had significant improvements in steatosis (-1.36 versus -0.41, P < 0.001), lobular inflammation (-0.82 versus -0.24, P = 0.03), ballooning injury (-1.27 versus -0.53, P = 0.03) and NAS (-3.45 versus -1.18, P < 0.001).Weight reduction achieved through lifestyle intervention leads to improvements in liver histology in NASH." @default.
• W1997425045 created "2016-06-24" @default.
• W1997425045 creator A5004731964 @default.
• W1997425045 creator A5043258226 @default.
• W1997425045 creator A5055200122 @default.
• W1997425045 creator A5065989965 @default.
• W1997425045 creator A5066195844 @default.
• W1997425045 creator A5072000707 @default.
• W1997425045 creator A5079705977 @default.
• W1997425045 creator A5086367826 @default.
• W1997425045 date "2009-09-09" @default.
• W1997425045 modified "2023-10-18" @default.
• W1997425045 title "Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis" @default.
• W1997425045 cites W1554005703 @default.
• W1997425045 cites W1596473973 @default.
• W1997425045 cites W1651866740 @default.
• W1997425045 cites W1968251114 @default.
• W1997425045 cites W1971895832 @default.
• W1997425045 cites W1983417944 @default.
• W1997425045 cites W1988981256 @default.
• W1997425045 cites W1993959691 @default.
• W1997425045 cites W1997229021 @default.
• W1997425045 cites W1998200598 @default.
• W1997425045 cites W2019280401 @default.
• W1997425045 cites W2029811522 @default.
• W1997425045 cites W2032486106 @default.
• W1997425045 cites W2032739324 @default.
• W1997425045 cites W2040109162 @default.
• W1997425045 cites W2046360039 @default.
• W1997425045 cites W2047499703 @default.
• W1997425045 cites W2061752687 @default.
• W1997425045 cites W2066800448 @default.
• W1997425045 cites W2067740038 @default.
• W1997425045 cites W2083896421 @default.
• W1997425045 cites W2103156933 @default.
• W1997425045 cites W2103714496 @default.
• W1997425045 cites W2111175328 @default.
• W1997425045 cites W2116891025 @default.
• W1997425045 cites W2123216266 @default.
• W1997425045 cites W2130421055 @default.
• W1997425045 cites W2130742202 @default.
• W1997425045 cites W2139112405 @default.
• W1997425045 cites W2142844314 @default.
• W1997425045 cites W2158822657 @default.
• W1997425045 cites W2168311757 @default.
• W1997425045 cites W2277297397 @default.
• W1997425045 cites W2303071711 @default.
• W1997425045 cites W2316193238 @default.
• W1997425045 cites W2615637571 @default.
• W1997425045 cites W4212961339 @default.
• W1997425045 doi "https://doi.org/10.1002/hep.23276" @default.
• W1997425045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2799538" @default.
• W1997425045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19827166" @default.
• W1997425045 hasPublicationYear "2009" @default.
• W1997425045 type Work @default.
• W1997425045 sameAs 1997425045 @default.
• W1997425045 citedByCount "1077" @default.
• W1997425045 countsByYear W19974250452012 @default.
• W1997425045 countsByYear W19974250452013 @default.
• W1997425045 countsByYear W19974250452014 @default.
• W1997425045 countsByYear W19974250452015 @default.
• W1997425045 countsByYear W19974250452016 @default.
• W1997425045 countsByYear W19974250452017 @default.
• W1997425045 countsByYear W19974250452018 @default.
• W1997425045 countsByYear W19974250452019 @default.
• W1997425045 countsByYear W19974250452020 @default.
• W1997425045 countsByYear W19974250452021 @default.
• W1997425045 countsByYear W19974250452022 @default.
• W1997425045 countsByYear W19974250452023 @default.
• W1997425045 crossrefType "journal-article" @default.
• W1997425045 hasAuthorship W1997425045A5004731964 @default.
• W1997425045 hasAuthorship W1997425045A5043258226 @default.
• W1997425045 hasAuthorship W1997425045A5055200122 @default.
• W1997425045 hasAuthorship W1997425045A5065989965 @default.
• W1997425045 hasAuthorship W1997425045A5066195844 @default.
• W1997425045 hasAuthorship W1997425045A5072000707 @default.
• W1997425045 hasAuthorship W1997425045A5079705977 @default.
• W1997425045 hasAuthorship W1997425045A5086367826 @default.
• W1997425045 hasBestOaLocation W19974250451 @default.
• W1997425045 hasConcept C126322002 @default.
• W1997425045 hasConcept C168563851 @default.
• W1997425045 hasConcept C1862650 @default.
• W1997425045 hasConcept C2776175330 @default.
• W1997425045 hasConcept C2776954865 @default.
• W1997425045 hasConcept C2778772119 @default.
• W1997425045 hasConcept C2779134260 @default.
• W1997425045 hasConcept C2780221984 @default.
• W1997425045 hasConcept C2780586474 @default.
• W1997425045 hasConcept C511355011 @default.
• W1997425045 hasConcept C544821477 @default.
• W1997425045 hasConcept C71924100 @default.
• W1997425045 hasConcept C90924648 @default.
• W1997425045 hasConceptScore W1997425045C126322002 @default.
• W1997425045 hasConceptScore W1997425045C168563851 @default.
• W1997425045 hasConceptScore W1997425045C1862650 @default.
• W1997425045 hasConceptScore W1997425045C2776175330 @default.
• W1997425045 hasConceptScore W1997425045C2776954865 @default.
• W1997425045 hasConceptScore W1997425045C2778772119 @default.

• next