Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997434013> ?p ?o ?g. }
- W1997434013 endingPage "104" @default.
- W1997434013 startingPage "95" @default.
- W1997434013 abstract "Integrity of the germline genome is essential for the production of viable gametes and successful reproduction. In mammals, the generation of gametes involves extensive epigenetic changes (DNA methylation and histone modification) in conjunction with changes in chromosome structure to ensure flawless progression through meiotic recombination and packaging of the genome into mature gametes. Although epigenetic reprogramming is essential for mammalian reproduction, reprogramming also provides a permissive window for exploitation by transposable elements (TEs), autonomously replicating endogenous elements. Expression and propagation of TEs during the reprogramming period can result in insertional mutagenesis that compromises genome integrity leading to reproductive problems and sporadic inherited diseases in offspring. Recent work has identified the germ cell associated PIWI Interacting RNA (piRNA) pathway in conjunction with the DNA methylation and histone modification machinery in silencing TEs. In this review we will highlight these recent advances in piRNA mediated regulation of TEs in the mouse germline, as well as mention the repercussions of failure to properly regulate TEs." @default.
- W1997434013 created "2016-06-24" @default.
- W1997434013 creator A5070563456 @default.
- W1997434013 creator A5071107449 @default.
- W1997434013 creator A5090818357 @default.
- W1997434013 date "2011-09-01" @default.
- W1997434013 modified "2023-10-01" @default.
- W1997434013 title "piRNAs, transposon silencing, and germline genome integrity" @default.
- W1997434013 cites W1509378838 @default.
- W1997434013 cites W1557790541 @default.
- W1997434013 cites W1870159184 @default.
- W1997434013 cites W1959325762 @default.
- W1997434013 cites W1965141089 @default.
- W1997434013 cites W1966150502 @default.
- W1997434013 cites W1969142635 @default.
- W1997434013 cites W1969865366 @default.
- W1997434013 cites W1970679679 @default.
- W1997434013 cites W1976342457 @default.
- W1997434013 cites W1977733607 @default.
- W1997434013 cites W1979954254 @default.
- W1997434013 cites W1981354816 @default.
- W1997434013 cites W1981615091 @default.
- W1997434013 cites W1981932058 @default.
- W1997434013 cites W1986319478 @default.
- W1997434013 cites W1986328541 @default.
- W1997434013 cites W1987332588 @default.
- W1997434013 cites W1987704199 @default.
- W1997434013 cites W1987872465 @default.
- W1997434013 cites W1988823631 @default.
- W1997434013 cites W1990654003 @default.
- W1997434013 cites W1990696681 @default.
- W1997434013 cites W1994528729 @default.
- W1997434013 cites W1996193092 @default.
- W1997434013 cites W1997873146 @default.
- W1997434013 cites W2002322555 @default.
- W1997434013 cites W2002541386 @default.
- W1997434013 cites W2003663539 @default.
- W1997434013 cites W2003911773 @default.
- W1997434013 cites W2004457665 @default.
- W1997434013 cites W2005764402 @default.
- W1997434013 cites W2007589425 @default.
- W1997434013 cites W2008289074 @default.
- W1997434013 cites W2009644747 @default.
- W1997434013 cites W2011213056 @default.
- W1997434013 cites W2013928795 @default.
- W1997434013 cites W2015231728 @default.
- W1997434013 cites W2015734897 @default.
- W1997434013 cites W2015782816 @default.
- W1997434013 cites W2016659849 @default.
- W1997434013 cites W2018304597 @default.
- W1997434013 cites W2020320730 @default.
- W1997434013 cites W2021243703 @default.
- W1997434013 cites W2023660667 @default.
- W1997434013 cites W2023844789 @default.
- W1997434013 cites W2023865653 @default.
- W1997434013 cites W2026322742 @default.
- W1997434013 cites W2026519705 @default.
- W1997434013 cites W2030656510 @default.
- W1997434013 cites W2035251095 @default.
- W1997434013 cites W2035566476 @default.
- W1997434013 cites W2035930185 @default.
- W1997434013 cites W2039684583 @default.
- W1997434013 cites W2040058302 @default.
- W1997434013 cites W2044611683 @default.
- W1997434013 cites W2044630496 @default.
- W1997434013 cites W2045739426 @default.
- W1997434013 cites W2046070361 @default.
- W1997434013 cites W2046415390 @default.
- W1997434013 cites W2048540261 @default.
- W1997434013 cites W2051443579 @default.
- W1997434013 cites W2054001786 @default.
- W1997434013 cites W2056938017 @default.
- W1997434013 cites W2057877925 @default.
- W1997434013 cites W2059053699 @default.
- W1997434013 cites W2059083852 @default.
- W1997434013 cites W2059792351 @default.
- W1997434013 cites W2064667228 @default.
- W1997434013 cites W2064967612 @default.
- W1997434013 cites W2067680909 @default.
- W1997434013 cites W2068584800 @default.
- W1997434013 cites W2068711892 @default.
- W1997434013 cites W2070945812 @default.
- W1997434013 cites W2071660897 @default.
- W1997434013 cites W2074644553 @default.
- W1997434013 cites W2075224242 @default.
- W1997434013 cites W2077053535 @default.
- W1997434013 cites W2077879161 @default.
- W1997434013 cites W2078478396 @default.
- W1997434013 cites W2078544214 @default.
- W1997434013 cites W2080056745 @default.
- W1997434013 cites W2080722280 @default.
- W1997434013 cites W2082061523 @default.
- W1997434013 cites W2084612103 @default.
- W1997434013 cites W2085154635 @default.
- W1997434013 cites W2086153601 @default.
- W1997434013 cites W2087073852 @default.
- W1997434013 cites W2089417246 @default.
- W1997434013 cites W2093606206 @default.