FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997438392> ?p ?o ?g. }

• W1997438392 endingPage "15430" @default.
• W1997438392 startingPage "15427" @default.
• W1997438392 abstract "Many drugs are amphiphiles that, in addition to binding to a particular target protein, adsorb to cell membrane lipid bilayers and alter intrinsic bilayer physical properties (e.g., bilayer thickness, monolayer curvature, and elastic moduli). Such changes can modulate membrane protein function by altering the energetic cost (DeltaG(bilayer)) of bilayer deformations associated with protein conformational changes that involve the protein-bilayer interface. But amphiphiles have complex effects on the physical properties of lipid bilayers, meaning that the net change in DeltaG(bilayer) cannot be predicted from measurements of isolated changes in such properties. Thus, the bilayer contribution to the promiscuous regulation of membrane proteins by drugs and other amphiphiles remains unknown. To overcome this problem, we use gramicidin A (gA) channels as molecular force probes to measure the net effect of amphiphiles, at concentrations often used in biological research, on the bilayer elastic response to a change in the hydrophobic length of an embedded protein. The effects of structurally diverse amphiphiles can be described by changes in a phenomenological bilayer spring constant (H(B)) that summarizes the bilayer elastic properties, as sensed by a bilayer-spanning protein. Amphiphile-induced changes in H(B), measured using gA channels of a particular length, quantitatively predict changes in lifetime for channels of a different length--as well as changes in the inactivation of voltage-dependent sodium channels in living cells. The use of gA channels as molecular force probes provides a tool for quantitative, predictive studies of bilayer-mediated regulation of membrane protein function by amphiphiles." @default.
• W1997438392 created "2016-06-24" @default.
• W1997438392 creator A5013774603 @default.
• W1997438392 creator A5029963830 @default.
• W1997438392 creator A5044485493 @default.
• W1997438392 date "2010-08-16" @default.
• W1997438392 modified "2023-09-25" @default.
• W1997438392 title "Amphiphile regulation of ion channel function by changes in the bilayer spring constant" @default.
• W1997438392 cites W1506842935 @default.
• W1997438392 cites W1545236729 @default.
• W1997438392 cites W1976081665 @default.
• W1997438392 cites W1978009405 @default.
• W1997438392 cites W1979324842 @default.
• W1997438392 cites W1985486587 @default.
• W1997438392 cites W2001925288 @default.
• W1997438392 cites W2021178815 @default.
• W1997438392 cites W2042721486 @default.
• W1997438392 cites W2048845010 @default.
• W1997438392 cites W2051221402 @default.
• W1997438392 cites W2054342311 @default.
• W1997438392 cites W2056202184 @default.
• W1997438392 cites W2062092582 @default.
• W1997438392 cites W2062458432 @default.
• W1997438392 cites W2072128651 @default.
• W1997438392 cites W2079714621 @default.
• W1997438392 cites W2096995495 @default.
• W1997438392 cites W2101934167 @default.
• W1997438392 cites W2112146921 @default.
• W1997438392 cites W2114469046 @default.
• W1997438392 cites W2115896474 @default.
• W1997438392 cites W2118560848 @default.
• W1997438392 cites W2124138679 @default.
• W1997438392 cites W2126014219 @default.
• W1997438392 cites W2129732513 @default.
• W1997438392 cites W2131028390 @default.
• W1997438392 cites W2151694767 @default.
• W1997438392 cites W2152241705 @default.
• W1997438392 cites W2167661324 @default.
• W1997438392 cites W4248107770 @default.
• W1997438392 doi "https://doi.org/10.1073/pnas.1007455107" @default.
• W1997438392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2932597" @default.
• W1997438392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20713738" @default.
• W1997438392 hasPublicationYear "2010" @default.
• W1997438392 type Work @default.
• W1997438392 sameAs 1997438392 @default.
• W1997438392 citedByCount "104" @default.
• W1997438392 countsByYear W19974383922012 @default.
• W1997438392 countsByYear W19974383922013 @default.
• W1997438392 countsByYear W19974383922014 @default.
• W1997438392 countsByYear W19974383922015 @default.
• W1997438392 countsByYear W19974383922016 @default.
• W1997438392 countsByYear W19974383922017 @default.
• W1997438392 countsByYear W19974383922018 @default.
• W1997438392 countsByYear W19974383922019 @default.
• W1997438392 countsByYear W19974383922020 @default.
• W1997438392 countsByYear W19974383922021 @default.
• W1997438392 countsByYear W19974383922022 @default.
• W1997438392 countsByYear W19974383922023 @default.
• W1997438392 crossrefType "journal-article" @default.
• W1997438392 hasAuthorship W1997438392A5013774603 @default.
• W1997438392 hasAuthorship W1997438392A5029963830 @default.
• W1997438392 hasAuthorship W1997438392A5044485493 @default.
• W1997438392 hasBestOaLocation W19974383921 @default.
• W1997438392 hasConcept C12554922 @default.
• W1997438392 hasConcept C144647389 @default.
• W1997438392 hasConcept C15920480 @default.
• W1997438392 hasConcept C178790620 @default.
• W1997438392 hasConcept C185592680 @default.
• W1997438392 hasConcept C192157962 @default.
• W1997438392 hasConcept C2779650302 @default.
• W1997438392 hasConcept C39944091 @default.
• W1997438392 hasConcept C41625074 @default.
• W1997438392 hasConcept C521977710 @default.
• W1997438392 hasConcept C55493867 @default.
• W1997438392 hasConcept C63491327 @default.
• W1997438392 hasConcept C67407626 @default.
• W1997438392 hasConcept C7070889 @default.
• W1997438392 hasConcept C76564549 @default.
• W1997438392 hasConcept C85145957 @default.
• W1997438392 hasConcept C86803240 @default.
• W1997438392 hasConceptScore W1997438392C12554922 @default.
• W1997438392 hasConceptScore W1997438392C144647389 @default.
• W1997438392 hasConceptScore W1997438392C15920480 @default.
• W1997438392 hasConceptScore W1997438392C178790620 @default.
• W1997438392 hasConceptScore W1997438392C185592680 @default.
• W1997438392 hasConceptScore W1997438392C192157962 @default.
• W1997438392 hasConceptScore W1997438392C2779650302 @default.
• W1997438392 hasConceptScore W1997438392C39944091 @default.
• W1997438392 hasConceptScore W1997438392C41625074 @default.
• W1997438392 hasConceptScore W1997438392C521977710 @default.
• W1997438392 hasConceptScore W1997438392C55493867 @default.
• W1997438392 hasConceptScore W1997438392C63491327 @default.
• W1997438392 hasConceptScore W1997438392C67407626 @default.
• W1997438392 hasConceptScore W1997438392C7070889 @default.
• W1997438392 hasConceptScore W1997438392C76564549 @default.
• W1997438392 hasConceptScore W1997438392C85145957 @default.
• W1997438392 hasConceptScore W1997438392C86803240 @default.
• W1997438392 hasIssue "35" @default.

• next