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• W1997441974 abstract "The variations found in determining the basal metabolisms are so considerable both as between different individuals and in the same individual on different occasions that it often involves considerable labour to show statistically the effects of drugs or other factors on the metabolism. In order to diminish the labour involved in such attempts, the author indicates a procedure in which, after setting out from determination of the total metabolism of several animals taken together, a mean value for the individual animals is found by dividing the total metabolism by the number of animals. This will apparently reduce the variation. The advantages and drawbacks of this procedure are discussed. The effects of temperature, sex and weight on the oxygen consumption of guinea-pigs were investigated in the way thus indicated. The oxygen consumption per sq. metre, as we found, increased by 9–15 % when the temperature fell from 32° C to 26° C, it being noted that the oxygen consumption of small animals increased relatively more than that of larger animals. If the body surface was estimated according to Vierordt's formula: body surface = K weight 2/3, the result indicated that males had a higher oxygen consumption per sq. metre than females; that at 26° C as well as at 32° the oxygen consumption per sq. metre diminished with increasing weight. If, however, the body surface was computed by experimentally found formulae, no difference between the relative oxygen consumption of males and females could be noted. Nor at 32° were there any statistically significant differences between the oxygen consumption/m2 of animals at different weights. At thermo-neutrality, therefore, the oxygen consumption/m2 appears to be practically constant in guinea-pigs weighing between 250 and 1,110 grams." @default.
• W1997441974 created "2016-06-24" @default.
• W1997441974 creator A5045862876 @default.
• W1997441974 date "1949-12-01" @default.
• W1997441974 modified "2023-10-17" @default.
• W1997441974 title "A Method for Reducing the Variation in Metabolism Tests, with Application to the Effects of Temperature, Sex and Weight on the Oxygen Consumption in Guinea-pigs" @default.
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• W1997441974 doi "https://doi.org/10.1111/j.1748-1716.1949.tb00619.x" @default.
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