Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997444976> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1997444976 endingPage "415" @default.
- W1997444976 startingPage "415" @default.
- W1997444976 abstract "The inhibition of microsomal mixed-function oxidations (MFO) by amphetamines was greatest for those compounds capable of forming metabolic intermediate (MI) complexes with cytochrome P-450 at fast rates. Ethylmorphine N-demethylase was least sensitive, p-nitroanisole O-demethylase was intermediate, and benzopyrene hydroxylase was the most sensitive reaction to amphetamine inhibition. Formation of MI complexes prior to initiating MFO reactions increased the degree of inhibition by adding a noncompetitive component to the initial competitive inhibition. This increased inhibition was only evident in microsomes from phenobarbital-pretreated animals, not those from untreated or 3-methylcholanthrene-pretreated animals. Hepatic MFO reactions in rabbit were more susceptible to inhibition than those of rat. In rabbit, lung benzopyrene hydroxylase was more susceptible to inhibition than liver. The formation of MI complexes from amphetamines can be a significant contributing factor to the inhibition of mixed-function oxidase reactions." @default.
- W1997444976 created "2016-06-24" @default.
- W1997444976 creator A5046053091 @default.
- W1997444976 date "1980-10-01" @default.
- W1997444976 modified "2023-09-28" @default.
- W1997444976 title "The role of mixed function oxidases in the activation of mutagens" @default.
- W1997444976 doi "https://doi.org/10.1016/0165-1161(80)90213-7" @default.
- W1997444976 hasPublicationYear "1980" @default.
- W1997444976 type Work @default.
- W1997444976 sameAs 1997444976 @default.
- W1997444976 citedByCount "0" @default.
- W1997444976 crossrefType "journal-article" @default.
- W1997444976 hasAuthorship W1997444976A5046053091 @default.
- W1997444976 hasConcept C104317684 @default.
- W1997444976 hasConcept C150757390 @default.
- W1997444976 hasConcept C181199279 @default.
- W1997444976 hasConcept C185592680 @default.
- W1997444976 hasConcept C2777466164 @default.
- W1997444976 hasConcept C2778793413 @default.
- W1997444976 hasConcept C2780753045 @default.
- W1997444976 hasConcept C2780768313 @default.
- W1997444976 hasConcept C2781364455 @default.
- W1997444976 hasConcept C2910828019 @default.
- W1997444976 hasConcept C38485361 @default.
- W1997444976 hasConcept C41091548 @default.
- W1997444976 hasConcept C526171541 @default.
- W1997444976 hasConcept C55493867 @default.
- W1997444976 hasConcept C86803240 @default.
- W1997444976 hasConcept C87644729 @default.
- W1997444976 hasConcept C98274493 @default.
- W1997444976 hasConceptScore W1997444976C104317684 @default.
- W1997444976 hasConceptScore W1997444976C150757390 @default.
- W1997444976 hasConceptScore W1997444976C181199279 @default.
- W1997444976 hasConceptScore W1997444976C185592680 @default.
- W1997444976 hasConceptScore W1997444976C2777466164 @default.
- W1997444976 hasConceptScore W1997444976C2778793413 @default.
- W1997444976 hasConceptScore W1997444976C2780753045 @default.
- W1997444976 hasConceptScore W1997444976C2780768313 @default.
- W1997444976 hasConceptScore W1997444976C2781364455 @default.
- W1997444976 hasConceptScore W1997444976C2910828019 @default.
- W1997444976 hasConceptScore W1997444976C38485361 @default.
- W1997444976 hasConceptScore W1997444976C41091548 @default.
- W1997444976 hasConceptScore W1997444976C526171541 @default.
- W1997444976 hasConceptScore W1997444976C55493867 @default.
- W1997444976 hasConceptScore W1997444976C86803240 @default.
- W1997444976 hasConceptScore W1997444976C87644729 @default.
- W1997444976 hasConceptScore W1997444976C98274493 @default.
- W1997444976 hasIssue "5" @default.
- W1997444976 hasLocation W19974449761 @default.
- W1997444976 hasOpenAccess W1997444976 @default.
- W1997444976 hasPrimaryLocation W19974449761 @default.
- W1997444976 hasRelatedWork W1187512893 @default.
- W1997444976 hasRelatedWork W1931472944 @default.
- W1997444976 hasRelatedWork W2042380097 @default.
- W1997444976 hasRelatedWork W2049240148 @default.
- W1997444976 hasRelatedWork W2111589725 @default.
- W1997444976 hasRelatedWork W2119698290 @default.
- W1997444976 hasRelatedWork W2334348102 @default.
- W1997444976 hasRelatedWork W2414027023 @default.
- W1997444976 hasRelatedWork W299269477 @default.
- W1997444976 hasRelatedWork W311222449 @default.
- W1997444976 hasVolume "74" @default.
- W1997444976 isParatext "false" @default.
- W1997444976 isRetracted "false" @default.
- W1997444976 magId "1997444976" @default.
- W1997444976 workType "article" @default.