FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997454807> ?p ?o ?g. }

• W1997454807 endingPage "4295" @default.
• W1997454807 startingPage "4288" @default.
• W1997454807 abstract "The structure and stability of single- and double-stranded DNA hybrids immobilized on gold are strongly affected by nucleotide-surface interactions. To systematically analyze the effects of these interactions, a set of model DNA hybrids was prepared in conformations that ranged from end-tethered double-stranded to directly adsorbed single-stranded (hairpins) and characterized by surface plasmon resonance (SPR) imaging, X-ray photoelectron spectroscopy (XPS), fluorescence microscopy, and near edge X-ray absorption fine structure (NEXAFS) spectroscopy. The stabilities of these hybrids were evaluated by exposure to a series of stringency rinses in solutions of successively lower ionic strength and by competitive hybridization experiments. In all cases, directly adsorbed DNA hybrids are found to be significantly less stable than either free or end-tethered hybrids. The surface-induced weakening and the associated asymmetry in hybridization responses of the two strands forming hairpin stems are most pronounced for single-stranded hairpins containing blocks of m adenine (A) nucleotides and n thymine (T) nucleotides, which have high and low affinity for gold surfaces, respectively. The results allow a qualitative scale of relative stabilities to be developed for DNA hybrids on surfaces. Additionally, the results suggest a route for selectively weakening portions of immobilized DNA hybrids and for introducing asymmetric hybridization responses by using sequence design to control nucleotide-surface interactions--a strategy that may be used in advanced biosensors and in switches or other active elements in DNA-based nanotechnology." @default.
• W1997454807 created "2016-06-24" @default.
• W1997454807 creator A5004116462 @default.
• W1997454807 creator A5009532720 @default.
• W1997454807 creator A5010457622 @default.
• W1997454807 creator A5017627792 @default.
• W1997454807 creator A5024558799 @default.
• W1997454807 creator A5033462159 @default.
• W1997454807 creator A5048989079 @default.
• W1997454807 creator A5077950297 @default.
• W1997454807 creator A5088181103 @default.
• W1997454807 creator A5090557189 @default.
• W1997454807 date "2011-05-11" @default.
• W1997454807 modified "2023-10-06" @default.
• W1997454807 title "Impact of DNA–Surface Interactions on the Stability of DNA Hybrids" @default.
• W1997454807 cites W1567477963 @default.
• W1997454807 cites W1968567751 @default.
• W1997454807 cites W1981708989 @default.
• W1997454807 cites W1990376706 @default.
• W1997454807 cites W2006155636 @default.
• W1997454807 cites W2009572926 @default.
• W1997454807 cites W2010995019 @default.
• W1997454807 cites W2012182308 @default.
• W1997454807 cites W2014318964 @default.
• W1997454807 cites W2014567256 @default.
• W1997454807 cites W2017359768 @default.
• W1997454807 cites W2026666952 @default.
• W1997454807 cites W2029260679 @default.
• W1997454807 cites W2030396602 @default.
• W1997454807 cites W2033223319 @default.
• W1997454807 cites W2034725224 @default.
• W1997454807 cites W2037330216 @default.
• W1997454807 cites W2037837139 @default.
• W1997454807 cites W2040026587 @default.
• W1997454807 cites W2041767969 @default.
• W1997454807 cites W2043424988 @default.
• W1997454807 cites W2043468628 @default.
• W1997454807 cites W2048531020 @default.
• W1997454807 cites W2053014859 @default.
• W1997454807 cites W2062752859 @default.
• W1997454807 cites W2062864075 @default.
• W1997454807 cites W2066275814 @default.
• W1997454807 cites W2077663958 @default.
• W1997454807 cites W2084798466 @default.
• W1997454807 cites W2085215574 @default.
• W1997454807 cites W2088728408 @default.
• W1997454807 cites W2095914211 @default.
• W1997454807 cites W2126961173 @default.
• W1997454807 cites W2139738498 @default.
• W1997454807 cites W2152835519 @default.
• W1997454807 cites W2164555399 @default.
• W1997454807 doi "https://doi.org/10.1021/ac200814y" @default.
• W1997454807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21561066" @default.
• W1997454807 hasPublicationYear "2011" @default.
• W1997454807 type Work @default.
• W1997454807 sameAs 1997454807 @default.
• W1997454807 citedByCount "66" @default.
• W1997454807 countsByYear W19974548072012 @default.
• W1997454807 countsByYear W19974548072013 @default.
• W1997454807 countsByYear W19974548072014 @default.
• W1997454807 countsByYear W19974548072015 @default.
• W1997454807 countsByYear W19974548072016 @default.
• W1997454807 countsByYear W19974548072017 @default.
• W1997454807 countsByYear W19974548072018 @default.
• W1997454807 countsByYear W19974548072019 @default.
• W1997454807 countsByYear W19974548072020 @default.
• W1997454807 countsByYear W19974548072021 @default.
• W1997454807 countsByYear W19974548072022 @default.
• W1997454807 countsByYear W19974548072023 @default.
• W1997454807 crossrefType "journal-article" @default.
• W1997454807 hasAuthorship W1997454807A5004116462 @default.
• W1997454807 hasAuthorship W1997454807A5009532720 @default.
• W1997454807 hasAuthorship W1997454807A5010457622 @default.
• W1997454807 hasAuthorship W1997454807A5017627792 @default.
• W1997454807 hasAuthorship W1997454807A5024558799 @default.
• W1997454807 hasAuthorship W1997454807A5033462159 @default.
• W1997454807 hasAuthorship W1997454807A5048989079 @default.
• W1997454807 hasAuthorship W1997454807A5077950297 @default.
• W1997454807 hasAuthorship W1997454807A5088181103 @default.
• W1997454807 hasAuthorship W1997454807A5090557189 @default.
• W1997454807 hasConcept C104317684 @default.
• W1997454807 hasConcept C106847996 @default.
• W1997454807 hasConcept C110715899 @default.
• W1997454807 hasConcept C121332964 @default.
• W1997454807 hasConcept C12554922 @default.
• W1997454807 hasConcept C127413603 @default.
• W1997454807 hasConcept C130197536 @default.
• W1997454807 hasConcept C150394285 @default.
• W1997454807 hasConcept C155672457 @default.
• W1997454807 hasConcept C160756335 @default.
• W1997454807 hasConcept C171250308 @default.
• W1997454807 hasConcept C175708663 @default.
• W1997454807 hasConcept C178790620 @default.
• W1997454807 hasConcept C185592680 @default.
• W1997454807 hasConcept C192562407 @default.
• W1997454807 hasConcept C32891209 @default.
• W1997454807 hasConcept C42360764 @default.
• W1997454807 hasConcept C512185932 @default.

• next