FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997462087> ?p ?o ?g. }

• W1997462087 endingPage "487" @default.
• W1997462087 startingPage "479" @default.
• W1997462087 abstract "D2 receptor null mutant (Drd2−/−) mice have altered responses to the rewarding and locomotor effects of psychostimulant drugs, which is evidence of a necessary role for D2 receptors in these behaviors. Furthermore, work with mice that constitutively express only the D2 receptor short form (D2S), as a result of genetic deletion of the long form (D2L), provides the basis for a current model in which D2L is thought to be the postsynaptic D2 receptor on medium spiny neurons in the basal forebrain, and D2S the autoreceptor that regulates the activity of dopamine neurons and dopamine synthesis and release. Because constitutive genetic deletion of the D2 or D2L receptor may cause compensatory changes that influence functional outcomes, our approach is to identify aspects of the abnormal phenotype of a Drd2−/− mouse that can be normalized by virus-mediated D2 receptor expression. Drd2−/− mice are deficient in basal and methamphetamine-induced locomotor activation and lack D2 receptor agonist-induced activation of G protein-regulated inward rectifying potassium channels (GIRKs) in dopaminergic neurons. Here we show that virus-mediated expression of D2L in the nucleus accumbens significantly restored methamphetamine-induced locomotor activation, but not basal locomotor activity, compared to mice receiving the control virus. It also restored the effect of methamphetamine to decrease time spent in the center of the activity chamber in female but not male Drd2−/− mice. Furthermore, the effect of expression of D2S was indistinguishable from D2L. Similarly, virus-mediated expression of either D2S or D2L in substantia nigra neurons restored D2 agonist-induced activation of GIRKs. In this acute expression system, the alternatively spliced forms of the D2 receptor appear to be equally capable of acting as postsynaptic receptors and autoreceptors." @default.
• W1997462087 created "2016-06-24" @default.
• W1997462087 creator A5008609077 @default.
• W1997462087 creator A5010686469 @default.
• W1997462087 creator A5010962738 @default.
• W1997462087 creator A5051549942 @default.
• W1997462087 creator A5084260138 @default.
• W1997462087 creator A5088619015 @default.
• W1997462087 date "2013-09-01" @default.
• W1997462087 modified "2023-10-03" @default.
• W1997462087 title "Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: Comparing D2L and D2S" @default.
• W1997462087 cites W1510708251 @default.
• W1997462087 cites W1546116904 @default.
• W1997462087 cites W1569254909 @default.
• W1997462087 cites W1624116415 @default.
• W1997462087 cites W1819218275 @default.
• W1997462087 cites W1955225173 @default.
• W1997462087 cites W1986185847 @default.
• W1997462087 cites W1989015059 @default.
• W1997462087 cites W2012111567 @default.
• W1997462087 cites W2016713233 @default.
• W1997462087 cites W2021784043 @default.
• W1997462087 cites W2024902308 @default.
• W1997462087 cites W2031422121 @default.
• W1997462087 cites W2032223397 @default.
• W1997462087 cites W2033712681 @default.
• W1997462087 cites W2037267899 @default.
• W1997462087 cites W2038370141 @default.
• W1997462087 cites W2054278011 @default.
• W1997462087 cites W2065967056 @default.
• W1997462087 cites W2079181083 @default.
• W1997462087 cites W2080107588 @default.
• W1997462087 cites W2084058724 @default.
• W1997462087 cites W2086880198 @default.
• W1997462087 cites W2088605934 @default.
• W1997462087 cites W2114208463 @default.
• W1997462087 cites W2118774378 @default.
• W1997462087 cites W2143541037 @default.
• W1997462087 cites W2146015054 @default.
• W1997462087 cites W2146663850 @default.
• W1997462087 cites W2165398609 @default.
• W1997462087 cites W2166217068 @default.
• W1997462087 doi "https://doi.org/10.1016/j.neuroscience.2013.06.035" @default.
• W1997462087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3858482" @default.
• W1997462087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23811070" @default.
• W1997462087 hasPublicationYear "2013" @default.
• W1997462087 type Work @default.
• W1997462087 sameAs 1997462087 @default.
• W1997462087 citedByCount "29" @default.
• W1997462087 countsByYear W19974620872014 @default.
• W1997462087 countsByYear W19974620872015 @default.
• W1997462087 countsByYear W19974620872016 @default.
• W1997462087 countsByYear W19974620872017 @default.
• W1997462087 countsByYear W19974620872018 @default.
• W1997462087 countsByYear W19974620872019 @default.
• W1997462087 countsByYear W19974620872020 @default.
• W1997462087 countsByYear W19974620872021 @default.
• W1997462087 countsByYear W19974620872022 @default.
• W1997462087 countsByYear W19974620872023 @default.
• W1997462087 crossrefType "journal-article" @default.
• W1997462087 hasAuthorship W1997462087A5008609077 @default.
• W1997462087 hasAuthorship W1997462087A5010686469 @default.
• W1997462087 hasAuthorship W1997462087A5010962738 @default.
• W1997462087 hasAuthorship W1997462087A5051549942 @default.
• W1997462087 hasAuthorship W1997462087A5084260138 @default.
• W1997462087 hasAuthorship W1997462087A5088619015 @default.
• W1997462087 hasBestOaLocation W19974620872 @default.
• W1997462087 hasConcept C126322002 @default.
• W1997462087 hasConcept C134018914 @default.
• W1997462087 hasConcept C137183658 @default.
• W1997462087 hasConcept C169760540 @default.
• W1997462087 hasConcept C170493617 @default.
• W1997462087 hasConcept C2776552330 @default.
• W1997462087 hasConcept C2778938600 @default.
• W1997462087 hasConcept C2780062018 @default.
• W1997462087 hasConcept C2780938664 @default.
• W1997462087 hasConcept C44208683 @default.
• W1997462087 hasConcept C513476851 @default.
• W1997462087 hasConcept C54355233 @default.
• W1997462087 hasConcept C71924100 @default.
• W1997462087 hasConcept C8439214 @default.
• W1997462087 hasConcept C85714458 @default.
• W1997462087 hasConcept C86803240 @default.
• W1997462087 hasConceptScore W1997462087C126322002 @default.
• W1997462087 hasConceptScore W1997462087C134018914 @default.
• W1997462087 hasConceptScore W1997462087C137183658 @default.
• W1997462087 hasConceptScore W1997462087C169760540 @default.
• W1997462087 hasConceptScore W1997462087C170493617 @default.
• W1997462087 hasConceptScore W1997462087C2776552330 @default.
• W1997462087 hasConceptScore W1997462087C2778938600 @default.
• W1997462087 hasConceptScore W1997462087C2780062018 @default.
• W1997462087 hasConceptScore W1997462087C2780938664 @default.
• W1997462087 hasConceptScore W1997462087C44208683 @default.
• W1997462087 hasConceptScore W1997462087C513476851 @default.
• W1997462087 hasConceptScore W1997462087C54355233 @default.
• W1997462087 hasConceptScore W1997462087C71924100 @default.
• W1997462087 hasConceptScore W1997462087C8439214 @default.
• W1997462087 hasConceptScore W1997462087C85714458 @default.

• next