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• W1997466211 abstract "A meta-analysis was performed in order to inventory the immune epitope data related to viruses in the genus Flavivirus. Nearly 2000 epitopes were captured from over 130 individual Flavivirus-related references identified from PubMed and reported as of September 2009. This report includes all epitope structures and associated immune reactivity from the past and current literature, including: the epitope distribution among pathogens and related strains, the epitope distribution among different pathogen antigens, the number of epitopes defined in human and animal models of disease, the relationship between epitopes identified in different disease states following natural (or experimental) infection, and data from studies focused on candidate vaccines. We found that the majority of epitopes were defined for dengue virus (DENV) and West Nile virus (WNV). The prominence of DENV and WNV data in the epitope literature is likely a reflection of their overall worldwide impact on human disease, and the lack of vaccines. Conversely, the relatively smaller number of epitopes defined for the other viruses within the genus (yellow fever and Japanese encephalitis virus) most likely reflects the presence of established prophylaxis and/or their more modest impact on morbidity and mortality globally. Through this work we hope to provide useful data to those working in the area of Flavivirus research." @default.
• W1997466211 created "2016-06-24" @default.
• W1997466211 creator A5010966529 @default.
• W1997466211 creator A5019742969 @default.
• W1997466211 creator A5023547268 @default.
• W1997466211 creator A5041376512 @default.
• W1997466211 creator A5063725110 @default.
• W1997466211 date "2010-06-01" @default.
• W1997466211 modified "2023-10-16" @default.
• W1997466211 title "Meta-analysis of All Immune Epitope Data in the<i>Flavivirus</i>Genus: Inventory of Current Immune Epitope Data Status in the Context of Virus Immunity and Immunopathology" @default.
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